Prevalence of Barrett's esophagus remains low in the korean population: Nationwide cross-sectional prospective multicenter study

In Seok Lee, Suck Chei Choi, Ki Nam Shim, Sam Ryong Jee, Kyu Chan Huh, Jun Haeng Lee, Kwang Jae Lee, Hyung Seok Park, Yong Chan Lee, Hoon Yong Jung, Hyo Jin Park

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Abstract

Purpose: In contrast to the Western population, the prevalence of Barrett's esophagus (BE) is rare in the Korean population. However, the recent increase in prevalence of gastroesophageal reflux disease (GERD) may affect the prevalence of BE. The aim of this study was to survey the prevalence of BE and evaluate its risk factors. Methods: Patients between 18 and 75 years of age who visited 11 Korean tertiary referral centers between April and July 2006 for routine upper endoscopic examination were surveyed using a symptom questionnaire. Biopsies were performed on the columnar lined epithelium (CLE) of the distal esophagus, and diagnosis was confirmed with detection of specialized intestinal metaplasia. Results: The study comprised 2,048 patients (mean age 51.4 years, 965 males). The frequency of heartburn or acid regurgitation was 8.7% and 13.1%, respectively. Reflux esophagitis was diagnosed in 10.1% of patients (207 patients); however, most patients had mild reflux. CLE was found in 82 patients; however, only one patient had long-segment CLE. The prevalence of BE was 1% (21 patients). The risk factors for BE were age (P = 0.006), presence of heartburn [odds ratio (OR) 4.33, 95% confidence interval (CI) 1.66-11.34, P = 0.007], acid regurgitation (OR 3.37, 95% CI 1.35-8.42, P = 0.01), sliding hernia (OR 6.21, 95% CI 1.78-21.72, P = 0.001), and reflux esophagitis (OR 10.28, 95% CI 4.31-24.50, P < 0.0001) on univariate analysis. On multivariate analysis, presence of typical reflux symptoms (P = 0.02) and reflux esophagitis (P < 0.001) were significant. Conclusions: Prevalence of Barrett's esophagus remains low in Koreans; however, risk of developing BE has increased in patients with GERD symptoms and reflux esophagitis.

Original languageEnglish
Pages (from-to)1932-1939
Number of pages8
JournalDigestive diseases and sciences
Volume55
Issue number7
DOIs
Publication statusPublished - 2010 Jul 1

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Barrett Esophagus
Multicenter Studies
Prospective Studies
Peptic Esophagitis
Population
Odds Ratio
Confidence Intervals
Heartburn
Epithelium
Gastroesophageal Reflux
Acids
Metaplasia
Hernia
Tertiary Care Centers
Esophagus
Multivariate Analysis
Biopsy

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

Lee, In Seok ; Choi, Suck Chei ; Shim, Ki Nam ; Jee, Sam Ryong ; Huh, Kyu Chan ; Lee, Jun Haeng ; Lee, Kwang Jae ; Park, Hyung Seok ; Lee, Yong Chan ; Jung, Hoon Yong ; Park, Hyo Jin. / Prevalence of Barrett's esophagus remains low in the korean population : Nationwide cross-sectional prospective multicenter study. In: Digestive diseases and sciences. 2010 ; Vol. 55, No. 7. pp. 1932-1939.
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title = "Prevalence of Barrett's esophagus remains low in the korean population: Nationwide cross-sectional prospective multicenter study",
abstract = "Purpose: In contrast to the Western population, the prevalence of Barrett's esophagus (BE) is rare in the Korean population. However, the recent increase in prevalence of gastroesophageal reflux disease (GERD) may affect the prevalence of BE. The aim of this study was to survey the prevalence of BE and evaluate its risk factors. Methods: Patients between 18 and 75 years of age who visited 11 Korean tertiary referral centers between April and July 2006 for routine upper endoscopic examination were surveyed using a symptom questionnaire. Biopsies were performed on the columnar lined epithelium (CLE) of the distal esophagus, and diagnosis was confirmed with detection of specialized intestinal metaplasia. Results: The study comprised 2,048 patients (mean age 51.4 years, 965 males). The frequency of heartburn or acid regurgitation was 8.7{\%} and 13.1{\%}, respectively. Reflux esophagitis was diagnosed in 10.1{\%} of patients (207 patients); however, most patients had mild reflux. CLE was found in 82 patients; however, only one patient had long-segment CLE. The prevalence of BE was 1{\%} (21 patients). The risk factors for BE were age (P = 0.006), presence of heartburn [odds ratio (OR) 4.33, 95{\%} confidence interval (CI) 1.66-11.34, P = 0.007], acid regurgitation (OR 3.37, 95{\%} CI 1.35-8.42, P = 0.01), sliding hernia (OR 6.21, 95{\%} CI 1.78-21.72, P = 0.001), and reflux esophagitis (OR 10.28, 95{\%} CI 4.31-24.50, P < 0.0001) on univariate analysis. On multivariate analysis, presence of typical reflux symptoms (P = 0.02) and reflux esophagitis (P < 0.001) were significant. Conclusions: Prevalence of Barrett's esophagus remains low in Koreans; however, risk of developing BE has increased in patients with GERD symptoms and reflux esophagitis.",
author = "Lee, {In Seok} and Choi, {Suck Chei} and Shim, {Ki Nam} and Jee, {Sam Ryong} and Huh, {Kyu Chan} and Lee, {Jun Haeng} and Lee, {Kwang Jae} and Park, {Hyung Seok} and Lee, {Yong Chan} and Jung, {Hoon Yong} and Park, {Hyo Jin}",
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Prevalence of Barrett's esophagus remains low in the korean population : Nationwide cross-sectional prospective multicenter study. / Lee, In Seok; Choi, Suck Chei; Shim, Ki Nam; Jee, Sam Ryong; Huh, Kyu Chan; Lee, Jun Haeng; Lee, Kwang Jae; Park, Hyung Seok; Lee, Yong Chan; Jung, Hoon Yong; Park, Hyo Jin.

In: Digestive diseases and sciences, Vol. 55, No. 7, 01.07.2010, p. 1932-1939.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prevalence of Barrett's esophagus remains low in the korean population

T2 - Nationwide cross-sectional prospective multicenter study

AU - Lee, In Seok

AU - Choi, Suck Chei

AU - Shim, Ki Nam

AU - Jee, Sam Ryong

AU - Huh, Kyu Chan

AU - Lee, Jun Haeng

AU - Lee, Kwang Jae

AU - Park, Hyung Seok

AU - Lee, Yong Chan

AU - Jung, Hoon Yong

AU - Park, Hyo Jin

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Purpose: In contrast to the Western population, the prevalence of Barrett's esophagus (BE) is rare in the Korean population. However, the recent increase in prevalence of gastroesophageal reflux disease (GERD) may affect the prevalence of BE. The aim of this study was to survey the prevalence of BE and evaluate its risk factors. Methods: Patients between 18 and 75 years of age who visited 11 Korean tertiary referral centers between April and July 2006 for routine upper endoscopic examination were surveyed using a symptom questionnaire. Biopsies were performed on the columnar lined epithelium (CLE) of the distal esophagus, and diagnosis was confirmed with detection of specialized intestinal metaplasia. Results: The study comprised 2,048 patients (mean age 51.4 years, 965 males). The frequency of heartburn or acid regurgitation was 8.7% and 13.1%, respectively. Reflux esophagitis was diagnosed in 10.1% of patients (207 patients); however, most patients had mild reflux. CLE was found in 82 patients; however, only one patient had long-segment CLE. The prevalence of BE was 1% (21 patients). The risk factors for BE were age (P = 0.006), presence of heartburn [odds ratio (OR) 4.33, 95% confidence interval (CI) 1.66-11.34, P = 0.007], acid regurgitation (OR 3.37, 95% CI 1.35-8.42, P = 0.01), sliding hernia (OR 6.21, 95% CI 1.78-21.72, P = 0.001), and reflux esophagitis (OR 10.28, 95% CI 4.31-24.50, P < 0.0001) on univariate analysis. On multivariate analysis, presence of typical reflux symptoms (P = 0.02) and reflux esophagitis (P < 0.001) were significant. Conclusions: Prevalence of Barrett's esophagus remains low in Koreans; however, risk of developing BE has increased in patients with GERD symptoms and reflux esophagitis.

AB - Purpose: In contrast to the Western population, the prevalence of Barrett's esophagus (BE) is rare in the Korean population. However, the recent increase in prevalence of gastroesophageal reflux disease (GERD) may affect the prevalence of BE. The aim of this study was to survey the prevalence of BE and evaluate its risk factors. Methods: Patients between 18 and 75 years of age who visited 11 Korean tertiary referral centers between April and July 2006 for routine upper endoscopic examination were surveyed using a symptom questionnaire. Biopsies were performed on the columnar lined epithelium (CLE) of the distal esophagus, and diagnosis was confirmed with detection of specialized intestinal metaplasia. Results: The study comprised 2,048 patients (mean age 51.4 years, 965 males). The frequency of heartburn or acid regurgitation was 8.7% and 13.1%, respectively. Reflux esophagitis was diagnosed in 10.1% of patients (207 patients); however, most patients had mild reflux. CLE was found in 82 patients; however, only one patient had long-segment CLE. The prevalence of BE was 1% (21 patients). The risk factors for BE were age (P = 0.006), presence of heartburn [odds ratio (OR) 4.33, 95% confidence interval (CI) 1.66-11.34, P = 0.007], acid regurgitation (OR 3.37, 95% CI 1.35-8.42, P = 0.01), sliding hernia (OR 6.21, 95% CI 1.78-21.72, P = 0.001), and reflux esophagitis (OR 10.28, 95% CI 4.31-24.50, P < 0.0001) on univariate analysis. On multivariate analysis, presence of typical reflux symptoms (P = 0.02) and reflux esophagitis (P < 0.001) were significant. Conclusions: Prevalence of Barrett's esophagus remains low in Koreans; however, risk of developing BE has increased in patients with GERD symptoms and reflux esophagitis.

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