Prevalence of Clostridium perfringens toxin in patients suspected of having antibiotic-associated diarrhea

Young Jin Kim, Si Hyun Kim, Junggu Ahn, Soongmoon Cho, Dongchun Kim, Kwanghyun Kim, Heegun Lee, Hyunwoo Son, Hee Joo Lee, DongEun Yong, JunYong Choi, Hye Ran Kim, Jeong Hwan Shin

Research output: Contribution to journalArticle

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Abstract

Background Although Clostridium perfringens has been reported as a cause of antibiotic-associated diarrhea (AAD), it is uncommon to detect this pathogen in clinical microbiology laboratories in Korea. The aim of this study was to investigate the prevalence of C. perfringens toxin in patients suspected of having AAD. Methods A total of 135 stool specimens submitted to a clinical microbiology laboratory for C. difficile toxin assay were tested. We tried to detect both C. difficile and C. perfringens toxins using the Seeplex Diarrhea ACE Detection kit (Seegene, Seoul, Korea). We evaluated the prevalence of 10 bacteria and 5 viruses. Results A total of 40 Clostridium spp. were detected in 34 specimens (29.6%). The C. perfringens toxin was detected in 14 of 135 specimens (10.4%), while C. difficile toxin was detected in 26 specimens (19.3%). Other bacteria and viruses, including 8 Aeromonas spp., were detected in 15 specimens. All tests were negative in 92 of the 135 specimens (68.1%). Conclusion Clostridium perfringens toxin is relatively common, and we should consider the possibility of its presence in patients suspected of having AAD, especially if C. difficile tests are negative.

Original languageEnglish
Pages (from-to)34-36
Number of pages3
JournalAnaerobe
Volume48
DOIs
Publication statusPublished - 2017 Dec 1

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Clostridium perfringens
Diarrhea
Anti-Bacterial Agents
Korea
Microbiology
Viruses
Bacteria
Aeromonas
Clostridium

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Infectious Diseases

Cite this

Kim, Young Jin ; Kim, Si Hyun ; Ahn, Junggu ; Cho, Soongmoon ; Kim, Dongchun ; Kim, Kwanghyun ; Lee, Heegun ; Son, Hyunwoo ; Lee, Hee Joo ; Yong, DongEun ; Choi, JunYong ; Kim, Hye Ran ; Shin, Jeong Hwan. / Prevalence of Clostridium perfringens toxin in patients suspected of having antibiotic-associated diarrhea. In: Anaerobe. 2017 ; Vol. 48. pp. 34-36.
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title = "Prevalence of Clostridium perfringens toxin in patients suspected of having antibiotic-associated diarrhea",
abstract = "Background Although Clostridium perfringens has been reported as a cause of antibiotic-associated diarrhea (AAD), it is uncommon to detect this pathogen in clinical microbiology laboratories in Korea. The aim of this study was to investigate the prevalence of C. perfringens toxin in patients suspected of having AAD. Methods A total of 135 stool specimens submitted to a clinical microbiology laboratory for C. difficile toxin assay were tested. We tried to detect both C. difficile and C. perfringens toxins using the Seeplex Diarrhea ACE Detection kit (Seegene, Seoul, Korea). We evaluated the prevalence of 10 bacteria and 5 viruses. Results A total of 40 Clostridium spp. were detected in 34 specimens (29.6{\%}). The C. perfringens toxin was detected in 14 of 135 specimens (10.4{\%}), while C. difficile toxin was detected in 26 specimens (19.3{\%}). Other bacteria and viruses, including 8 Aeromonas spp., were detected in 15 specimens. All tests were negative in 92 of the 135 specimens (68.1{\%}). Conclusion Clostridium perfringens toxin is relatively common, and we should consider the possibility of its presence in patients suspected of having AAD, especially if C. difficile tests are negative.",
author = "Kim, {Young Jin} and Kim, {Si Hyun} and Junggu Ahn and Soongmoon Cho and Dongchun Kim and Kwanghyun Kim and Heegun Lee and Hyunwoo Son and Lee, {Hee Joo} and DongEun Yong and JunYong Choi and Kim, {Hye Ran} and Shin, {Jeong Hwan}",
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Kim, YJ, Kim, SH, Ahn, J, Cho, S, Kim, D, Kim, K, Lee, H, Son, H, Lee, HJ, Yong, D, Choi, J, Kim, HR & Shin, JH 2017, 'Prevalence of Clostridium perfringens toxin in patients suspected of having antibiotic-associated diarrhea', Anaerobe, vol. 48, pp. 34-36. https://doi.org/10.1016/j.anaerobe.2017.06.015

Prevalence of Clostridium perfringens toxin in patients suspected of having antibiotic-associated diarrhea. / Kim, Young Jin; Kim, Si Hyun; Ahn, Junggu; Cho, Soongmoon; Kim, Dongchun; Kim, Kwanghyun; Lee, Heegun; Son, Hyunwoo; Lee, Hee Joo; Yong, DongEun; Choi, JunYong; Kim, Hye Ran; Shin, Jeong Hwan.

In: Anaerobe, Vol. 48, 01.12.2017, p. 34-36.

Research output: Contribution to journalArticle

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AU - Kim, Young Jin

AU - Kim, Si Hyun

AU - Ahn, Junggu

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AU - Kim, Dongchun

AU - Kim, Kwanghyun

AU - Lee, Heegun

AU - Son, Hyunwoo

AU - Lee, Hee Joo

AU - Yong, DongEun

AU - Choi, JunYong

AU - Kim, Hye Ran

AU - Shin, Jeong Hwan

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N2 - Background Although Clostridium perfringens has been reported as a cause of antibiotic-associated diarrhea (AAD), it is uncommon to detect this pathogen in clinical microbiology laboratories in Korea. The aim of this study was to investigate the prevalence of C. perfringens toxin in patients suspected of having AAD. Methods A total of 135 stool specimens submitted to a clinical microbiology laboratory for C. difficile toxin assay were tested. We tried to detect both C. difficile and C. perfringens toxins using the Seeplex Diarrhea ACE Detection kit (Seegene, Seoul, Korea). We evaluated the prevalence of 10 bacteria and 5 viruses. Results A total of 40 Clostridium spp. were detected in 34 specimens (29.6%). The C. perfringens toxin was detected in 14 of 135 specimens (10.4%), while C. difficile toxin was detected in 26 specimens (19.3%). Other bacteria and viruses, including 8 Aeromonas spp., were detected in 15 specimens. All tests were negative in 92 of the 135 specimens (68.1%). Conclusion Clostridium perfringens toxin is relatively common, and we should consider the possibility of its presence in patients suspected of having AAD, especially if C. difficile tests are negative.

AB - Background Although Clostridium perfringens has been reported as a cause of antibiotic-associated diarrhea (AAD), it is uncommon to detect this pathogen in clinical microbiology laboratories in Korea. The aim of this study was to investigate the prevalence of C. perfringens toxin in patients suspected of having AAD. Methods A total of 135 stool specimens submitted to a clinical microbiology laboratory for C. difficile toxin assay were tested. We tried to detect both C. difficile and C. perfringens toxins using the Seeplex Diarrhea ACE Detection kit (Seegene, Seoul, Korea). We evaluated the prevalence of 10 bacteria and 5 viruses. Results A total of 40 Clostridium spp. were detected in 34 specimens (29.6%). The C. perfringens toxin was detected in 14 of 135 specimens (10.4%), while C. difficile toxin was detected in 26 specimens (19.3%). Other bacteria and viruses, including 8 Aeromonas spp., were detected in 15 specimens. All tests were negative in 92 of the 135 specimens (68.1%). Conclusion Clostridium perfringens toxin is relatively common, and we should consider the possibility of its presence in patients suspected of having AAD, especially if C. difficile tests are negative.

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