Prevalence of co-morbidities and evaluation of their monitoring in Korean patients with rheumatoid arthritis: comparison with the results of an international, cross-sectional study (COMORA)

In Ah Choi, Sung Hwan Park, Hoon Suk Cha, Won Park, Hyun Ah Kim, Dae Hyun Yoo, Han Joo Baek, Seong Geun Lee, Yun Jong Lee, Yong Bum Park, Seung Cheol Shim, Ihsane Hmamouchi, Yeong Wook Song

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4 Citations (Scopus)

Abstract

Aim: We designed this study to evaluate the prevalence of comorbidities, their monitoring states and association with treatment medication in Korean rheumatoid arthritis (RA) patients compared with patients from other countries. Methods: We analyzed 1050 RA patients from 11 Korean centers and compared them with 3520 patients from 16 other countries using an international, cross-sectional study evaluating comorbidities of RA (COMORA) database. Results: Annual evaluations of cardiovascular (CV) risk were less frequently performed in Korea (P = 0.0011). The prevalence of CV-associated morbidity was similar between Korean and international RA patients, although the proportions of current smokers, patients with a family history of CV disease, patients with hyperlipidemia, and patients with Framingham score > 20% were significantly lower in Korea (P < 0.0001 for all), and the antiplatelet agents were more optimally used in Korea (P = 0.0004). Prostate cancer screening was less frequently performed compared to other countries (P < 0.0001). Less than 10% of Korean RA patients were given influenza and pneumococcal vaccinations according to current recommendations. Conclusions: There are differences in the prevalence of comorbidities and monitoring states of the risk factors between patients in Korea and in other countries. The prevalence of CV morbidity was similar between the two groups although the prevalence of CV risk factors was significantly low in Korea, suggesting that rheumatologists in Korea need to pay more attention to yearly CV risk monitoring, in addition to the screening of malignancy and vaccination of RA patients against infectious diseases.

Original languageEnglish
Pages (from-to)1414-1422
Number of pages9
JournalInternational Journal of Rheumatic Diseases
Volume21
Issue number7
DOIs
Publication statusPublished - 2018 Jul

Bibliographical note

Funding Information:
Data collection was supported by an unrestricted grant from Roche. The ancillary study described in this manuscript was conducted with the support of a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI14C1277) and by a grant from the Ministry of Science, ICT and Future Planning (NRF-2015M3A9B6052011). The authors would like to thank the national principal investigators of the COMORA study: Gustavo Casado (Argentina), Josef Smolen (Austria), Bassel Kamal El-Zorkany (Egypt), Martin Soubrier (France), Gerd Burmester (Germany), Peter Balint (Hungary), Carlo Maurizio Montecucco (Italy), Masayoshi Harigai (Japan), Najia Hajjaj-Hassouni (Morocco), Mart van de Laar (the Netherlands), Emilio Martin-Mola (Spain), Shue-Fen Luo (Taiwan), Jonathan Kay and Kevin Winthrop (USA), Gabriel Maciel (Uruguay), Anna Antunez (Venezuela); and the scientific committee of the COMORA study who permitted and supported this ancillary analysis: Maxime Dougados, Peter Balint, Gerd Burmester, Paul Emery, Jonathan Kay, Emilio Martin-Mola, Iain McInnes, Carlo Maurizio Montecucco, Josef Smolen, and patients who agreed to participate in this study.

Funding Information:
Data collection was supported by an unrestricted grant from Roche. The ancillary study described in this manuscript was conducted with the support of a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI14C1277) and by a grant from the Ministry of Science, ICT and Future Planning (NRF-2015M3A9B6052011).

Publisher Copyright:
© 2017 The Authors. International Journal of Rheumatic Diseases published by Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.

All Science Journal Classification (ASJC) codes

  • Rheumatology

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