Prevalence of depression and suicidal ideation increases proportionally with renal function decline, beginning from early stages of chronic kidney disease

Jong H. Jhee, Eun Lee, Min Uk Cha, Misol Lee, Hyoungnae Kim, Seohyun Park, Hae Ryong Yun, Su Young Jung, Youn K. Kee, Chang Yun Yoon, Seung H. Han, Tae Hyun Yoo, Shin Wook Kang, Jung T. Park

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Depression and suicidal ideation are prevalent mental health problems in patients with chronic kidney disease (CKD. However, the association between mental health problems and kidney disease has been investigated in severe cases only. Thus, this study evaluated the relationship between mental health problems and renal function in a community-based prospective cohort study comprising patients with mild to moderate kidney disease. A total of 44,938 participants who were participated in Korean National Health and Nutrition Examination Survey IV, V, and VI from 2007 to 2014 were enrolled. Estimated glomerular filtration rate (eGFR) was calculated using the CKD Epidemiology Collaboration equation. The study outcome was the prevalence of depression and suicidal ideations assessed by self-reporting surveys. Logistic regression analysis was performed to evaluate the relationship between renal function and outcomes. The mean age of the study subjects was 49.2 ± 16.6 years, and the mean eGFR was 94.0 mL/min/1.73 m2. The prevalence of depression and suicidal ideation increased with decreasing eGFR. Multivariate logistic regression analysis showed that the risk of depression increased in subjects with eGFR <45 mL/min/1.73 m2 [odds ratio (OR) 1.47; 95% confidence interval (CI) 1.09–1.98]. The risk of suicidal ideation gradually increased in groups with eGFR <90 mL/min/1.73 m2 (OR, 1.11; 95% CI, 1.03–1.20), even after adjustments for confounding variables. In conclusion, depression and suicidal ideation are related closely with renal dysfunction. The risk of having depression and suicidal ideation increased even in patient with mild renal dysfunction. Therefore, evaluation and management strategies regarding mental health problems should be taken into account throughout all stages of CKD.

Original languageEnglish
Article numbere8476
JournalMedicine (United States)
Volume96
Issue number44
DOIs
Publication statusPublished - 2017 Nov

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Suicidal Ideation
Chronic Renal Insufficiency
Glomerular Filtration Rate
Depression
Kidney
Mental Health
Kidney Diseases
Mental Health Associations
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals
Confounding Factors (Epidemiology)
Nutrition Surveys
Epidemiology
Cohort Studies
Outcome Assessment (Health Care)
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Jhee, Jong H. ; Lee, Eun ; Cha, Min Uk ; Lee, Misol ; Kim, Hyoungnae ; Park, Seohyun ; Yun, Hae Ryong ; Jung, Su Young ; Kee, Youn K. ; Yoon, Chang Yun ; Han, Seung H. ; Yoo, Tae Hyun ; Kang, Shin Wook ; Park, Jung T. / Prevalence of depression and suicidal ideation increases proportionally with renal function decline, beginning from early stages of chronic kidney disease. In: Medicine (United States). 2017 ; Vol. 96, No. 44.
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abstract = "Depression and suicidal ideation are prevalent mental health problems in patients with chronic kidney disease (CKD. However, the association between mental health problems and kidney disease has been investigated in severe cases only. Thus, this study evaluated the relationship between mental health problems and renal function in a community-based prospective cohort study comprising patients with mild to moderate kidney disease. A total of 44,938 participants who were participated in Korean National Health and Nutrition Examination Survey IV, V, and VI from 2007 to 2014 were enrolled. Estimated glomerular filtration rate (eGFR) was calculated using the CKD Epidemiology Collaboration equation. The study outcome was the prevalence of depression and suicidal ideations assessed by self-reporting surveys. Logistic regression analysis was performed to evaluate the relationship between renal function and outcomes. The mean age of the study subjects was 49.2 ± 16.6 years, and the mean eGFR was 94.0 mL/min/1.73 m2. The prevalence of depression and suicidal ideation increased with decreasing eGFR. Multivariate logistic regression analysis showed that the risk of depression increased in subjects with eGFR <45 mL/min/1.73 m2 [odds ratio (OR) 1.47; 95{\%} confidence interval (CI) 1.09–1.98]. The risk of suicidal ideation gradually increased in groups with eGFR <90 mL/min/1.73 m2 (OR, 1.11; 95{\%} CI, 1.03–1.20), even after adjustments for confounding variables. In conclusion, depression and suicidal ideation are related closely with renal dysfunction. The risk of having depression and suicidal ideation increased even in patient with mild renal dysfunction. Therefore, evaluation and management strategies regarding mental health problems should be taken into account throughout all stages of CKD.",
author = "Jhee, {Jong H.} and Eun Lee and Cha, {Min Uk} and Misol Lee and Hyoungnae Kim and Seohyun Park and Yun, {Hae Ryong} and Jung, {Su Young} and Kee, {Youn K.} and Yoon, {Chang Yun} and Han, {Seung H.} and Yoo, {Tae Hyun} and Kang, {Shin Wook} and Park, {Jung T.}",
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Prevalence of depression and suicidal ideation increases proportionally with renal function decline, beginning from early stages of chronic kidney disease. / Jhee, Jong H.; Lee, Eun; Cha, Min Uk; Lee, Misol; Kim, Hyoungnae; Park, Seohyun; Yun, Hae Ryong; Jung, Su Young; Kee, Youn K.; Yoon, Chang Yun; Han, Seung H.; Yoo, Tae Hyun; Kang, Shin Wook; Park, Jung T.

In: Medicine (United States), Vol. 96, No. 44, e8476, 11.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prevalence of depression and suicidal ideation increases proportionally with renal function decline, beginning from early stages of chronic kidney disease

AU - Jhee, Jong H.

AU - Lee, Eun

AU - Cha, Min Uk

AU - Lee, Misol

AU - Kim, Hyoungnae

AU - Park, Seohyun

AU - Yun, Hae Ryong

AU - Jung, Su Young

AU - Kee, Youn K.

AU - Yoon, Chang Yun

AU - Han, Seung H.

AU - Yoo, Tae Hyun

AU - Kang, Shin Wook

AU - Park, Jung T.

PY - 2017/11

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N2 - Depression and suicidal ideation are prevalent mental health problems in patients with chronic kidney disease (CKD. However, the association between mental health problems and kidney disease has been investigated in severe cases only. Thus, this study evaluated the relationship between mental health problems and renal function in a community-based prospective cohort study comprising patients with mild to moderate kidney disease. A total of 44,938 participants who were participated in Korean National Health and Nutrition Examination Survey IV, V, and VI from 2007 to 2014 were enrolled. Estimated glomerular filtration rate (eGFR) was calculated using the CKD Epidemiology Collaboration equation. The study outcome was the prevalence of depression and suicidal ideations assessed by self-reporting surveys. Logistic regression analysis was performed to evaluate the relationship between renal function and outcomes. The mean age of the study subjects was 49.2 ± 16.6 years, and the mean eGFR was 94.0 mL/min/1.73 m2. The prevalence of depression and suicidal ideation increased with decreasing eGFR. Multivariate logistic regression analysis showed that the risk of depression increased in subjects with eGFR <45 mL/min/1.73 m2 [odds ratio (OR) 1.47; 95% confidence interval (CI) 1.09–1.98]. The risk of suicidal ideation gradually increased in groups with eGFR <90 mL/min/1.73 m2 (OR, 1.11; 95% CI, 1.03–1.20), even after adjustments for confounding variables. In conclusion, depression and suicidal ideation are related closely with renal dysfunction. The risk of having depression and suicidal ideation increased even in patient with mild renal dysfunction. Therefore, evaluation and management strategies regarding mental health problems should be taken into account throughout all stages of CKD.

AB - Depression and suicidal ideation are prevalent mental health problems in patients with chronic kidney disease (CKD. However, the association between mental health problems and kidney disease has been investigated in severe cases only. Thus, this study evaluated the relationship between mental health problems and renal function in a community-based prospective cohort study comprising patients with mild to moderate kidney disease. A total of 44,938 participants who were participated in Korean National Health and Nutrition Examination Survey IV, V, and VI from 2007 to 2014 were enrolled. Estimated glomerular filtration rate (eGFR) was calculated using the CKD Epidemiology Collaboration equation. The study outcome was the prevalence of depression and suicidal ideations assessed by self-reporting surveys. Logistic regression analysis was performed to evaluate the relationship between renal function and outcomes. The mean age of the study subjects was 49.2 ± 16.6 years, and the mean eGFR was 94.0 mL/min/1.73 m2. The prevalence of depression and suicidal ideation increased with decreasing eGFR. Multivariate logistic regression analysis showed that the risk of depression increased in subjects with eGFR <45 mL/min/1.73 m2 [odds ratio (OR) 1.47; 95% confidence interval (CI) 1.09–1.98]. The risk of suicidal ideation gradually increased in groups with eGFR <90 mL/min/1.73 m2 (OR, 1.11; 95% CI, 1.03–1.20), even after adjustments for confounding variables. In conclusion, depression and suicidal ideation are related closely with renal dysfunction. The risk of having depression and suicidal ideation increased even in patient with mild renal dysfunction. Therefore, evaluation and management strategies regarding mental health problems should be taken into account throughout all stages of CKD.

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