Prevalence of intracranial aneurysms in patients with aortic dissection

W. S. Jung, J. H. Kim, S. J. Ahn, S. W. Song, B. M. Kim, K. D. Seo, S. H. Suh

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: There is an uncertainty about the association between intracranial aneurysms and aortic dissection. We aimed to determine the prevalence of intracranial aneurysms in patients with aortic dissection and evaluate the independent risk factors for the presence of intracranial aneurysms in these patients. MATERIALS AND METHODS: Seventy-one patients with a confirmed aortic dissection who underwent additional brain imaging were enrolled as the aortic dissection group, and 2118 healthy individuals with brain imaging, as controls. Demographic data were obtained from their medical records, including age, sex, comorbidities, and arch vessel involvement of aortic dissection. Two readers reviewed all brain images independently regarding the presence, morphology, size, and location of intracranial aneurysms. Baseline characteristics were compared between the aortic dissection group and controls by propensity score matching, and logistic regression analysis was performed for independent risk factors for the presence of intracranial aneurysms. RESULTS: The prevalence of intracranial aneurysms was 12.96% in the aortic dissection group and 1.85% in controls (P = .022). The mean diameter of intracranial aneurysms was significantly larger in the aortic dissection group (5.79±3.26mmin aortic dissection versus 3.04± 1.57 mm in controls; P = .008), and intracranial aneurysms of >7 mm were also more common in the aortic dissection group (28.6% in aortic dissection versus 5.3% in controls, P=.003). On multivariate analysis, arch vessel involvement of aortic dissection was an independent risk factor for the presence of intracranial aneurysms (odds ratio, 6.246; 95% confidence interval, 1.472-26.50; P=.013). CONCLUSIONS: Patients with aortic dissection have a high prevalence of intracranial aneurysms, and selective screening for brain vessels could be considered in these patients with arch vessel involvement. A further prospective study is needed to demonstrate a substantial prevalence of intracranial aneurysms.

Original languageEnglish
Pages (from-to)2089-2093
Number of pages5
JournalAmerican Journal of Neuroradiology
Volume38
Issue number11
DOIs
Publication statusPublished - 2017 Nov 1

Bibliographical note

Funding Information:
Received April 6, 2017; accepted after revision June 23. From the Departments of Radiology (W.S.J., S.J.A., S.H.S.), Neurology (J.H.K.), and Cardiovascular Surgery (S.-W.S.), Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; Department of Radiology (W.S.J.), Ajou University School of Medicine, Suwon, Korea; Department of Radiology (B.M.K.) and Severance Institute of Vascular and Metabolic Research (S.H.S.), Yonsei University College of Medicine, Seoul, Korea; and Department of Neurology (K.-D.S.), Wonkwang University Sanbon Hospital, Seoul, Korea. This work was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare, Republic of Korea (grant No. HC15C1056).

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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