Prevalence of metabolic syndrome in patients with schizophrenia in Korea: A multicenter nationwide cross-sectional study

Jung Sun Lee, Jun Soo Kwon, Daeho Kim, Sung Wan Kim, Jae Jin Kim, Jong Hoon Kim, Hee Jung Nam, Seunghyong Ryu, Il Ho Park, Suk Kyoon An, Hong Seok Oh, Seunghee Won, Kanguk Lee, Kyu Young Lee, Seung Hwan Lee, Yu Sang Lee, Jung Seo Yi, Kyung Sue Hong, Yeon Ho Joo

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8 Citations (Scopus)

Abstract

Objective We designed a nationwide study with limited exclusion criteria to investigate the prevalence of metabolic syndrome (MetS) in Korea and its relationship with antipsychotic medications. Methods This multicenter, cross-sectional, and observational study included patients diagnosed with schizophrenia or schizoaffective disorder. Sixteen hospitals enrolled 845 patients aged 18 to 65 years prescribed any antipsychotic medication between August 2011 and August 2013. MetS was diagnosed using the criteria of the modified Adult Treatment Panel III of the National Cholesterol Education Program with the Korean abdominal obesity definition (waist circumference ≥85 cm in women, ≥90 cm in men). Results The prevalence of MetS in all patients was 36.5% and was significantly higher in men than women (men, 40.8%; women, 32.2%) and was significantly correlated with age [odds ratio (OR) 1.02] and duration of illness (OR 1.03). The prevalence of MetS across antipsychotic drugs in the major monotherapy group was as follows: 18.8% for quetiapine, 22.0% for aripiprazole, 33.3% for both amisulpride and paliperidone, 34.0% for olanzapine, 35% for risperidone, 39.4% for haloperidol, and 44.7% for clozapine. Conclusion The prevalence of MetS is very high in patients with schizophrenia or schizoaffective disorder. Screening and monitoring of MetS is also strongly recommended.

Original languageEnglish
Pages (from-to)44-50
Number of pages7
JournalPsychiatry Investigation
Volume14
Issue number1
DOIs
Publication statusPublished - 2017 Jan

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Lee, J. S., Kwon, J. S., Kim, D., Kim, S. W., Kim, J. J., Kim, J. H., Nam, H. J., Ryu, S., Park, I. H., An, S. K., Oh, H. S., Won, S., Lee, K., Lee, K. Y., Lee, S. H., Lee, Y. S., Yi, J. S., Hong, K. S., & Joo, Y. H. (2017). Prevalence of metabolic syndrome in patients with schizophrenia in Korea: A multicenter nationwide cross-sectional study. Psychiatry Investigation, 14(1), 44-50. https://doi.org/10.4306/pi.2017.14.1.44