Prevalence of neuropathic pain and patient-reported outcomes in Korean adults with chronic low back pain resulting from neuropathic low back pain

Jin Hwan Kim, Jae Taek Hong, Chong Suh Lee, Keun Su Kim, Kyung Soo Suk, Jin Hyok Kim, Ye Soo Park, Bong Soon Chang, Deuk Soo Jun, Young Hoon Kim, Jung Hee Lee, Woo Kie Min, Jung Sub Lee, Si Young Park, In Soo Oh, Jae Young Hong, Hyun Chul Shin, Woo Kyung Kim, Joo Han Kim, Jung Kil Lee & 10 others In Soo Kim, Yoon Ha, Soo Bin Im, Sang Woo Kim, In Ho Han, Jun Jae Shin, Byeong Cheol Rim, Bo Jeong Seo, Young Joo Kim, Juneyoung Lee

Research output: Contribution to journalArticle

Abstract

Study Design: A noninterventional, multicenter, cross-sectional study. Purpose: We investigated the prevalence of neuropathic pain (NP) and patient-reported outcomes (PROs) of the quality of life (QoL) and functional disability in Korean adults with chronic low back pain (CLBP). Overview of Literature: Among patients with CLBP, 20%-55% had NP. Methods: Patients older than 20 years with CLBP lasting for longer than three months, with a visual analog scale (VAS) pain score higher than four, and with pain medications being used for at least four weeks before enrollment were recruited from 27 general hospitals between December 2014 and May 2015. Medical chart reviews were performed to collect demographic/clinical features and diagnosis of NP (douleur neuropathique 4, DN4). The QoL (EuroQoL 5-dimension, EQ-5D; EQ-VAS) and functional disability (Quebec Back Pain Disability Scale, QBPDS) were determined through patient surveys. Multiple linear regression analyses were performed to compare PROs between the NP (DN4=4) and non-NP (DN4 < 4) groups. Results: A total of 1,200 patients (females: 65.7%; mean age: 63.4±13.0 years) were enrolled. The mean scores of EQ-5D, EQ-VAS, and QBPDS were 0.5±0.3, 55.7±19.4, and 40.4±21.1, respectively. Among all patients, 492 (41.0%; 95% confidence interval, 38.2%- 43.8%) suffered from NP. The prevalence of NP was higher in male patients (46.8%; p < 0.01), in patients who had pain based on radiological and neurological findings (59.0%; p < 0.01), and in patients who had severe pain (49.0%; p < 0.01). There were significant mean differences in EQ-5D (NP group vs. non-NP group: 0.4±0.3 vs. 0.5±0.3; p < 0.01) and QBPDS (NP group vs. non-NP group: 45.8±21.2 vs. 36.3±20.2; p < 0.01) scores. In the multiple linear regression, patients with NP showed lower EQ-5D (β=-0.1; p < 0.01) and higher QBPDS (β=7.0; p < 0.01) scores than those without NP. Conclusions: NP was highly prevalent in Korean patients with CLBP. Patients with CLBP having NP had a lower QoL and more severe dysfunction than those without NP. To enhance the QoL and functional status of patients with CLBP, this study highlights the importance of appropriately diagnosing and treating NP.

Original languageEnglish
Pages (from-to)917-927
Number of pages11
JournalAsian Spine Journal
Volume11
Issue number6
DOIs
Publication statusPublished - 2017 Dec 1

Fingerprint

Neuralgia
Low Back Pain
Quebec
Back Pain
Pain
Quality of Life
Patient Reported Outcome Measures
Visual Analog Scale
Linear Models
Pain Measurement
General Hospitals
Cross-Sectional Studies

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Kim, Jin Hwan ; Hong, Jae Taek ; Lee, Chong Suh ; Kim, Keun Su ; Suk, Kyung Soo ; Kim, Jin Hyok ; Park, Ye Soo ; Chang, Bong Soon ; Jun, Deuk Soo ; Kim, Young Hoon ; Lee, Jung Hee ; Min, Woo Kie ; Lee, Jung Sub ; Park, Si Young ; Oh, In Soo ; Hong, Jae Young ; Shin, Hyun Chul ; Kim, Woo Kyung ; Kim, Joo Han ; Lee, Jung Kil ; Kim, In Soo ; Ha, Yoon ; Im, Soo Bin ; Kim, Sang Woo ; Han, In Ho ; Shin, Jun Jae ; Rim, Byeong Cheol ; Seo, Bo Jeong ; Kim, Young Joo ; Lee, Juneyoung. / Prevalence of neuropathic pain and patient-reported outcomes in Korean adults with chronic low back pain resulting from neuropathic low back pain. In: Asian Spine Journal. 2017 ; Vol. 11, No. 6. pp. 917-927.
@article{bf9cb98f4e3d4b54bf2a6a88b17a5942,
title = "Prevalence of neuropathic pain and patient-reported outcomes in Korean adults with chronic low back pain resulting from neuropathic low back pain",
abstract = "Study Design: A noninterventional, multicenter, cross-sectional study. Purpose: We investigated the prevalence of neuropathic pain (NP) and patient-reported outcomes (PROs) of the quality of life (QoL) and functional disability in Korean adults with chronic low back pain (CLBP). Overview of Literature: Among patients with CLBP, 20{\%}-55{\%} had NP. Methods: Patients older than 20 years with CLBP lasting for longer than three months, with a visual analog scale (VAS) pain score higher than four, and with pain medications being used for at least four weeks before enrollment were recruited from 27 general hospitals between December 2014 and May 2015. Medical chart reviews were performed to collect demographic/clinical features and diagnosis of NP (douleur neuropathique 4, DN4). The QoL (EuroQoL 5-dimension, EQ-5D; EQ-VAS) and functional disability (Quebec Back Pain Disability Scale, QBPDS) were determined through patient surveys. Multiple linear regression analyses were performed to compare PROs between the NP (DN4=4) and non-NP (DN4 < 4) groups. Results: A total of 1,200 patients (females: 65.7{\%}; mean age: 63.4±13.0 years) were enrolled. The mean scores of EQ-5D, EQ-VAS, and QBPDS were 0.5±0.3, 55.7±19.4, and 40.4±21.1, respectively. Among all patients, 492 (41.0{\%}; 95{\%} confidence interval, 38.2{\%}- 43.8{\%}) suffered from NP. The prevalence of NP was higher in male patients (46.8{\%}; p < 0.01), in patients who had pain based on radiological and neurological findings (59.0{\%}; p < 0.01), and in patients who had severe pain (49.0{\%}; p < 0.01). There were significant mean differences in EQ-5D (NP group vs. non-NP group: 0.4±0.3 vs. 0.5±0.3; p < 0.01) and QBPDS (NP group vs. non-NP group: 45.8±21.2 vs. 36.3±20.2; p < 0.01) scores. In the multiple linear regression, patients with NP showed lower EQ-5D (β=-0.1; p < 0.01) and higher QBPDS (β=7.0; p < 0.01) scores than those without NP. Conclusions: NP was highly prevalent in Korean patients with CLBP. Patients with CLBP having NP had a lower QoL and more severe dysfunction than those without NP. To enhance the QoL and functional status of patients with CLBP, this study highlights the importance of appropriately diagnosing and treating NP.",
author = "Kim, {Jin Hwan} and Hong, {Jae Taek} and Lee, {Chong Suh} and Kim, {Keun Su} and Suk, {Kyung Soo} and Kim, {Jin Hyok} and Park, {Ye Soo} and Chang, {Bong Soon} and Jun, {Deuk Soo} and Kim, {Young Hoon} and Lee, {Jung Hee} and Min, {Woo Kie} and Lee, {Jung Sub} and Park, {Si Young} and Oh, {In Soo} and Hong, {Jae Young} and Shin, {Hyun Chul} and Kim, {Woo Kyung} and Kim, {Joo Han} and Lee, {Jung Kil} and Kim, {In Soo} and Yoon Ha and Im, {Soo Bin} and Kim, {Sang Woo} and Han, {In Ho} and Shin, {Jun Jae} and Rim, {Byeong Cheol} and Seo, {Bo Jeong} and Kim, {Young Joo} and Juneyoung Lee",
year = "2017",
month = "12",
day = "1",
doi = "10.4184/asj.2017.11.6.917",
language = "English",
volume = "11",
pages = "917--927",
journal = "Asian Spine Journal",
issn = "1976-1902",
publisher = "Korean Society of Spine Surgery",
number = "6",

}

Kim, JH, Hong, JT, Lee, CS, Kim, KS, Suk, KS, Kim, JH, Park, YS, Chang, BS, Jun, DS, Kim, YH, Lee, JH, Min, WK, Lee, JS, Park, SY, Oh, IS, Hong, JY, Shin, HC, Kim, WK, Kim, JH, Lee, JK, Kim, IS, Ha, Y, Im, SB, Kim, SW, Han, IH, Shin, JJ, Rim, BC, Seo, BJ, Kim, YJ & Lee, J 2017, 'Prevalence of neuropathic pain and patient-reported outcomes in Korean adults with chronic low back pain resulting from neuropathic low back pain', Asian Spine Journal, vol. 11, no. 6, pp. 917-927. https://doi.org/10.4184/asj.2017.11.6.917

Prevalence of neuropathic pain and patient-reported outcomes in Korean adults with chronic low back pain resulting from neuropathic low back pain. / Kim, Jin Hwan; Hong, Jae Taek; Lee, Chong Suh; Kim, Keun Su; Suk, Kyung Soo; Kim, Jin Hyok; Park, Ye Soo; Chang, Bong Soon; Jun, Deuk Soo; Kim, Young Hoon; Lee, Jung Hee; Min, Woo Kie; Lee, Jung Sub; Park, Si Young; Oh, In Soo; Hong, Jae Young; Shin, Hyun Chul; Kim, Woo Kyung; Kim, Joo Han; Lee, Jung Kil; Kim, In Soo; Ha, Yoon; Im, Soo Bin; Kim, Sang Woo; Han, In Ho; Shin, Jun Jae; Rim, Byeong Cheol; Seo, Bo Jeong; Kim, Young Joo; Lee, Juneyoung.

In: Asian Spine Journal, Vol. 11, No. 6, 01.12.2017, p. 917-927.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prevalence of neuropathic pain and patient-reported outcomes in Korean adults with chronic low back pain resulting from neuropathic low back pain

AU - Kim, Jin Hwan

AU - Hong, Jae Taek

AU - Lee, Chong Suh

AU - Kim, Keun Su

AU - Suk, Kyung Soo

AU - Kim, Jin Hyok

AU - Park, Ye Soo

AU - Chang, Bong Soon

AU - Jun, Deuk Soo

AU - Kim, Young Hoon

AU - Lee, Jung Hee

AU - Min, Woo Kie

AU - Lee, Jung Sub

AU - Park, Si Young

AU - Oh, In Soo

AU - Hong, Jae Young

AU - Shin, Hyun Chul

AU - Kim, Woo Kyung

AU - Kim, Joo Han

AU - Lee, Jung Kil

AU - Kim, In Soo

AU - Ha, Yoon

AU - Im, Soo Bin

AU - Kim, Sang Woo

AU - Han, In Ho

AU - Shin, Jun Jae

AU - Rim, Byeong Cheol

AU - Seo, Bo Jeong

AU - Kim, Young Joo

AU - Lee, Juneyoung

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Study Design: A noninterventional, multicenter, cross-sectional study. Purpose: We investigated the prevalence of neuropathic pain (NP) and patient-reported outcomes (PROs) of the quality of life (QoL) and functional disability in Korean adults with chronic low back pain (CLBP). Overview of Literature: Among patients with CLBP, 20%-55% had NP. Methods: Patients older than 20 years with CLBP lasting for longer than three months, with a visual analog scale (VAS) pain score higher than four, and with pain medications being used for at least four weeks before enrollment were recruited from 27 general hospitals between December 2014 and May 2015. Medical chart reviews were performed to collect demographic/clinical features and diagnosis of NP (douleur neuropathique 4, DN4). The QoL (EuroQoL 5-dimension, EQ-5D; EQ-VAS) and functional disability (Quebec Back Pain Disability Scale, QBPDS) were determined through patient surveys. Multiple linear regression analyses were performed to compare PROs between the NP (DN4=4) and non-NP (DN4 < 4) groups. Results: A total of 1,200 patients (females: 65.7%; mean age: 63.4±13.0 years) were enrolled. The mean scores of EQ-5D, EQ-VAS, and QBPDS were 0.5±0.3, 55.7±19.4, and 40.4±21.1, respectively. Among all patients, 492 (41.0%; 95% confidence interval, 38.2%- 43.8%) suffered from NP. The prevalence of NP was higher in male patients (46.8%; p < 0.01), in patients who had pain based on radiological and neurological findings (59.0%; p < 0.01), and in patients who had severe pain (49.0%; p < 0.01). There were significant mean differences in EQ-5D (NP group vs. non-NP group: 0.4±0.3 vs. 0.5±0.3; p < 0.01) and QBPDS (NP group vs. non-NP group: 45.8±21.2 vs. 36.3±20.2; p < 0.01) scores. In the multiple linear regression, patients with NP showed lower EQ-5D (β=-0.1; p < 0.01) and higher QBPDS (β=7.0; p < 0.01) scores than those without NP. Conclusions: NP was highly prevalent in Korean patients with CLBP. Patients with CLBP having NP had a lower QoL and more severe dysfunction than those without NP. To enhance the QoL and functional status of patients with CLBP, this study highlights the importance of appropriately diagnosing and treating NP.

AB - Study Design: A noninterventional, multicenter, cross-sectional study. Purpose: We investigated the prevalence of neuropathic pain (NP) and patient-reported outcomes (PROs) of the quality of life (QoL) and functional disability in Korean adults with chronic low back pain (CLBP). Overview of Literature: Among patients with CLBP, 20%-55% had NP. Methods: Patients older than 20 years with CLBP lasting for longer than three months, with a visual analog scale (VAS) pain score higher than four, and with pain medications being used for at least four weeks before enrollment were recruited from 27 general hospitals between December 2014 and May 2015. Medical chart reviews were performed to collect demographic/clinical features and diagnosis of NP (douleur neuropathique 4, DN4). The QoL (EuroQoL 5-dimension, EQ-5D; EQ-VAS) and functional disability (Quebec Back Pain Disability Scale, QBPDS) were determined through patient surveys. Multiple linear regression analyses were performed to compare PROs between the NP (DN4=4) and non-NP (DN4 < 4) groups. Results: A total of 1,200 patients (females: 65.7%; mean age: 63.4±13.0 years) were enrolled. The mean scores of EQ-5D, EQ-VAS, and QBPDS were 0.5±0.3, 55.7±19.4, and 40.4±21.1, respectively. Among all patients, 492 (41.0%; 95% confidence interval, 38.2%- 43.8%) suffered from NP. The prevalence of NP was higher in male patients (46.8%; p < 0.01), in patients who had pain based on radiological and neurological findings (59.0%; p < 0.01), and in patients who had severe pain (49.0%; p < 0.01). There were significant mean differences in EQ-5D (NP group vs. non-NP group: 0.4±0.3 vs. 0.5±0.3; p < 0.01) and QBPDS (NP group vs. non-NP group: 45.8±21.2 vs. 36.3±20.2; p < 0.01) scores. In the multiple linear regression, patients with NP showed lower EQ-5D (β=-0.1; p < 0.01) and higher QBPDS (β=7.0; p < 0.01) scores than those without NP. Conclusions: NP was highly prevalent in Korean patients with CLBP. Patients with CLBP having NP had a lower QoL and more severe dysfunction than those without NP. To enhance the QoL and functional status of patients with CLBP, this study highlights the importance of appropriately diagnosing and treating NP.

UR - http://www.scopus.com/inward/record.url?scp=85038633887&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85038633887&partnerID=8YFLogxK

U2 - 10.4184/asj.2017.11.6.917

DO - 10.4184/asj.2017.11.6.917

M3 - Article

VL - 11

SP - 917

EP - 927

JO - Asian Spine Journal

JF - Asian Spine Journal

SN - 1976-1902

IS - 6

ER -