Prevalence of ocular hypertension and glaucoma as well as associated factors in graves' orbitopathy

Ji Won Kim, Jae Sang Ko, Young Jun Woo, Hyoung Won Bae, Jinsook Yoon

Research output: Contribution to journalArticle

Abstract

Purpose: The purpose of this study was to determine the prevalence of ocular hypertension (OHT) and open-Angle glaucoma (OAG) in patients with Graves' orbitopathy (GO) and to investigate the associations between clinical features of the disease and the prevalence of OHT and OAG. Methods: A cross-sectional analytic study was conducted among a total of 1128 patients with GO. A complete ophthalmic examination was performed, including intraocular pressure, optic disc photography, visual field testing using a Humphrey visual field analyzer, and retinal nerve fiber layer thickness measured by optical coherence tomography. The results were analyzed by univariate and multivariate logistic regression. Results: A 6.8% prevalence of OHT (77/1128) and a 1.6% prevalence of OAG (18/1128) were observed. When considering only patients older than 40 years, the prevalence of OHT and OAG was 9.5% and 3.4%, respectively. Twenty-nine of the 1128 patients (2.6%) developed compressive optic neuropathy. Of the factors evaluated, male sex [odds ratio (OR), 1.83; 95% confidence interval (CI), 1.08-3.10], duration of GO (6 to 24mo; OR, 2.08; 95% CI, 1.17-3.71; 24 to 60mo; OR, 3.45; 95% CI, 1.66-7.18), clinical activity score ≥3 (OR, 1.76; 95% CI, 1.03- 3.01), extraocular muscle involvement (OR, 4.65; 95% CI, 2.54-8.50), and lid retraction (OR, 2.17; 95% CI, 1.19-3.96) were associated with the prevalence of OHT in GO. The prevalence of OAG was associated with male sex (OR, 4.29; 95% CI, 1.60-11.51) and duration of GO (≥60 mo; OR, 4.28; 95% CI, 1.11-16.47). Conclusions: The prevalence of OHT in patients with GO was higher and the prevalence of OAG was similar to that in the general population.

Original languageEnglish
Pages (from-to)464-469
Number of pages6
JournalJournal of Glaucoma
Volume27
Issue number5
DOIs
Publication statusPublished - 2018 Jan 1

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Ocular Hypertension
Glaucoma
Open Angle Glaucoma
Odds Ratio
Confidence Intervals
Sex Ratio
Visual Fields
Oculomotor Muscles
Optic Nerve Diseases
Photography
Optic Disk
Optical Coherence Tomography
Intraocular Pressure
Nerve Fibers
Cross-Sectional Studies
Logistic Models

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Kim, Ji Won ; Ko, Jae Sang ; Woo, Young Jun ; Bae, Hyoung Won ; Yoon, Jinsook. / Prevalence of ocular hypertension and glaucoma as well as associated factors in graves' orbitopathy. In: Journal of Glaucoma. 2018 ; Vol. 27, No. 5. pp. 464-469.
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abstract = "Purpose: The purpose of this study was to determine the prevalence of ocular hypertension (OHT) and open-Angle glaucoma (OAG) in patients with Graves' orbitopathy (GO) and to investigate the associations between clinical features of the disease and the prevalence of OHT and OAG. Methods: A cross-sectional analytic study was conducted among a total of 1128 patients with GO. A complete ophthalmic examination was performed, including intraocular pressure, optic disc photography, visual field testing using a Humphrey visual field analyzer, and retinal nerve fiber layer thickness measured by optical coherence tomography. The results were analyzed by univariate and multivariate logistic regression. Results: A 6.8{\%} prevalence of OHT (77/1128) and a 1.6{\%} prevalence of OAG (18/1128) were observed. When considering only patients older than 40 years, the prevalence of OHT and OAG was 9.5{\%} and 3.4{\%}, respectively. Twenty-nine of the 1128 patients (2.6{\%}) developed compressive optic neuropathy. Of the factors evaluated, male sex [odds ratio (OR), 1.83; 95{\%} confidence interval (CI), 1.08-3.10], duration of GO (6 to 24mo; OR, 2.08; 95{\%} CI, 1.17-3.71; 24 to 60mo; OR, 3.45; 95{\%} CI, 1.66-7.18), clinical activity score ≥3 (OR, 1.76; 95{\%} CI, 1.03- 3.01), extraocular muscle involvement (OR, 4.65; 95{\%} CI, 2.54-8.50), and lid retraction (OR, 2.17; 95{\%} CI, 1.19-3.96) were associated with the prevalence of OHT in GO. The prevalence of OAG was associated with male sex (OR, 4.29; 95{\%} CI, 1.60-11.51) and duration of GO (≥60 mo; OR, 4.28; 95{\%} CI, 1.11-16.47). Conclusions: The prevalence of OHT in patients with GO was higher and the prevalence of OAG was similar to that in the general population.",
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Prevalence of ocular hypertension and glaucoma as well as associated factors in graves' orbitopathy. / Kim, Ji Won; Ko, Jae Sang; Woo, Young Jun; Bae, Hyoung Won; Yoon, Jinsook.

In: Journal of Glaucoma, Vol. 27, No. 5, 01.01.2018, p. 464-469.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prevalence of ocular hypertension and glaucoma as well as associated factors in graves' orbitopathy

AU - Kim, Ji Won

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N2 - Purpose: The purpose of this study was to determine the prevalence of ocular hypertension (OHT) and open-Angle glaucoma (OAG) in patients with Graves' orbitopathy (GO) and to investigate the associations between clinical features of the disease and the prevalence of OHT and OAG. Methods: A cross-sectional analytic study was conducted among a total of 1128 patients with GO. A complete ophthalmic examination was performed, including intraocular pressure, optic disc photography, visual field testing using a Humphrey visual field analyzer, and retinal nerve fiber layer thickness measured by optical coherence tomography. The results were analyzed by univariate and multivariate logistic regression. Results: A 6.8% prevalence of OHT (77/1128) and a 1.6% prevalence of OAG (18/1128) were observed. When considering only patients older than 40 years, the prevalence of OHT and OAG was 9.5% and 3.4%, respectively. Twenty-nine of the 1128 patients (2.6%) developed compressive optic neuropathy. Of the factors evaluated, male sex [odds ratio (OR), 1.83; 95% confidence interval (CI), 1.08-3.10], duration of GO (6 to 24mo; OR, 2.08; 95% CI, 1.17-3.71; 24 to 60mo; OR, 3.45; 95% CI, 1.66-7.18), clinical activity score ≥3 (OR, 1.76; 95% CI, 1.03- 3.01), extraocular muscle involvement (OR, 4.65; 95% CI, 2.54-8.50), and lid retraction (OR, 2.17; 95% CI, 1.19-3.96) were associated with the prevalence of OHT in GO. The prevalence of OAG was associated with male sex (OR, 4.29; 95% CI, 1.60-11.51) and duration of GO (≥60 mo; OR, 4.28; 95% CI, 1.11-16.47). Conclusions: The prevalence of OHT in patients with GO was higher and the prevalence of OAG was similar to that in the general population.

AB - Purpose: The purpose of this study was to determine the prevalence of ocular hypertension (OHT) and open-Angle glaucoma (OAG) in patients with Graves' orbitopathy (GO) and to investigate the associations between clinical features of the disease and the prevalence of OHT and OAG. Methods: A cross-sectional analytic study was conducted among a total of 1128 patients with GO. A complete ophthalmic examination was performed, including intraocular pressure, optic disc photography, visual field testing using a Humphrey visual field analyzer, and retinal nerve fiber layer thickness measured by optical coherence tomography. The results were analyzed by univariate and multivariate logistic regression. Results: A 6.8% prevalence of OHT (77/1128) and a 1.6% prevalence of OAG (18/1128) were observed. When considering only patients older than 40 years, the prevalence of OHT and OAG was 9.5% and 3.4%, respectively. Twenty-nine of the 1128 patients (2.6%) developed compressive optic neuropathy. Of the factors evaluated, male sex [odds ratio (OR), 1.83; 95% confidence interval (CI), 1.08-3.10], duration of GO (6 to 24mo; OR, 2.08; 95% CI, 1.17-3.71; 24 to 60mo; OR, 3.45; 95% CI, 1.66-7.18), clinical activity score ≥3 (OR, 1.76; 95% CI, 1.03- 3.01), extraocular muscle involvement (OR, 4.65; 95% CI, 2.54-8.50), and lid retraction (OR, 2.17; 95% CI, 1.19-3.96) were associated with the prevalence of OHT in GO. The prevalence of OAG was associated with male sex (OR, 4.29; 95% CI, 1.60-11.51) and duration of GO (≥60 mo; OR, 4.28; 95% CI, 1.11-16.47). Conclusions: The prevalence of OHT in patients with GO was higher and the prevalence of OAG was similar to that in the general population.

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