Prevalence, timing, and predictors of transitions from inhalant use to Inhalant Use Disorders

Brian E. Perron, Matthew O. Howard, Samopriyo Maitra, Michael George Vaughn

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Few studies of the natural history of DSM-IV inhalant substance use disorders (I-SUDs) have been conducted. This investigation examined the prevalence, timing, and predictors of transitions from inhalant use to formal I-SUDs among inhalant users within a nationally representative sample. Methods: Participants were 664 U.S. residents participating in the 2000-2001 National Epidemiologic Survey on Alcohol and Related Conditions who reported lifetime inhalant use. Respondents completed structured interviews assessing DSM-IV psychiatric/substance use disorders. Bivariate and Cox regression analyses were conducted to identify risk factors for transitions from inhalant use to I-SUDs. Results: Nearly one in five (19.4%) persons initiating inhalant use developed an I-SUD. Most I-SUD transitions were to inhalant abuse rather than inhalant dependence. Risk for development of I-SUDs was greatest in the first year following initiation of inhalant use and low thereafter. Multivariate proportional hazards models indicated that presence of a mood/anxiety disorder (HR = 7.7, CI = 3.1-18.9) or alcohol use disorder (HR = 11.9, CI = 5.46-26.00) antedating initiation of inhalant use predicted significantly elevated risk for I-SUDs, whereas being married conferred a lower risk for onset of I-SUDs. Conclusions: I-SUDs were relatively common among inhalant users, generally occurred in the year following initiation of inhalant use, and were associated with early-onset mood/anxiety and alcohol use disorders. Given the young average age at onset of inhalant use and the rapidity with which most I-SUDs developed, interventions directed to adolescents who have initiated inhalant use might be effective in reducing the proportion of inhalant users who develop I-SUDs.

Original languageEnglish
Pages (from-to)277-284
Number of pages8
JournalDrug and Alcohol Dependence
Volume100
Issue number3
DOIs
Publication statusPublished - 2009 Mar 1

Fingerprint

Substance-Related Disorders
Alcohols
Hazards
Diagnostic and Statistical Manual of Mental Disorders
Inhalant Abuse
Anxiety Disorders
Natural History
Mood Disorders
Age of Onset
Proportional Hazards Models
Psychiatry
Anxiety
Regression Analysis
Interviews

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Perron, Brian E. ; Howard, Matthew O. ; Maitra, Samopriyo ; Vaughn, Michael George. / Prevalence, timing, and predictors of transitions from inhalant use to Inhalant Use Disorders. In: Drug and Alcohol Dependence. 2009 ; Vol. 100, No. 3. pp. 277-284.
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Prevalence, timing, and predictors of transitions from inhalant use to Inhalant Use Disorders. / Perron, Brian E.; Howard, Matthew O.; Maitra, Samopriyo; Vaughn, Michael George.

In: Drug and Alcohol Dependence, Vol. 100, No. 3, 01.03.2009, p. 277-284.

Research output: Contribution to journalArticle

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N2 - Background: Few studies of the natural history of DSM-IV inhalant substance use disorders (I-SUDs) have been conducted. This investigation examined the prevalence, timing, and predictors of transitions from inhalant use to formal I-SUDs among inhalant users within a nationally representative sample. Methods: Participants were 664 U.S. residents participating in the 2000-2001 National Epidemiologic Survey on Alcohol and Related Conditions who reported lifetime inhalant use. Respondents completed structured interviews assessing DSM-IV psychiatric/substance use disorders. Bivariate and Cox regression analyses were conducted to identify risk factors for transitions from inhalant use to I-SUDs. Results: Nearly one in five (19.4%) persons initiating inhalant use developed an I-SUD. Most I-SUD transitions were to inhalant abuse rather than inhalant dependence. Risk for development of I-SUDs was greatest in the first year following initiation of inhalant use and low thereafter. Multivariate proportional hazards models indicated that presence of a mood/anxiety disorder (HR = 7.7, CI = 3.1-18.9) or alcohol use disorder (HR = 11.9, CI = 5.46-26.00) antedating initiation of inhalant use predicted significantly elevated risk for I-SUDs, whereas being married conferred a lower risk for onset of I-SUDs. Conclusions: I-SUDs were relatively common among inhalant users, generally occurred in the year following initiation of inhalant use, and were associated with early-onset mood/anxiety and alcohol use disorders. Given the young average age at onset of inhalant use and the rapidity with which most I-SUDs developed, interventions directed to adolescents who have initiated inhalant use might be effective in reducing the proportion of inhalant users who develop I-SUDs.

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