Prevention of protein and polymeric nanoparticles adsorption using perfluoropolyether

Sunil Kwon, Hyungtae Kim, Jong Wook Ha, Sang Yup Lee

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


A fluoropolymer, perfluoropolyether (PFPE) was examined as an anti-adsorbing material that prevents protein and nanoparticle adsorption. PFPE has a fluoroalkyl chain that has low surface energy with both hydrophobicity and oleophobicity. Exploiting these properties, selective adsorption of protein and polymeric nanoparticles was achieved on a micropatterned surface where PFPE passivated the surface against adsorption of biomolecular and polymeric nanoparticles. Adsorption of model particles, bovine serum albumin (BSA) and latex nanoparticle, were tested on the patterned surface. PFPE remarkably prevented the adsorption of both nanoparticles while considerable adsorption of nanoparticles was observed on the negatively charged carboxyl-terminated surface. This outcome suggests that PFPE is a promising coating material that can be exploited for anti-biofouling.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
JournalJournal of Industrial and Engineering Chemistry
Issue number2
Publication statusPublished - 2011 Mar 25

Bibliographical note

Funding Information:
This work was supported by grant (no. 2008-E032) funded by the Ministery of Knowledge Economy, Korea. We would like to express our appreciation to Dr. W.G. Koh at Yonsei Univeristy for the gift of the PDMS stamp.

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)


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