Prevention of protein and polymeric nanoparticles adsorption using perfluoropolyether

Sunil Kwon, Hyungtae Kim, Jong Wook Ha, Sang Yup Lee

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A fluoropolymer, perfluoropolyether (PFPE) was examined as an anti-adsorbing material that prevents protein and nanoparticle adsorption. PFPE has a fluoroalkyl chain that has low surface energy with both hydrophobicity and oleophobicity. Exploiting these properties, selective adsorption of protein and polymeric nanoparticles was achieved on a micropatterned surface where PFPE passivated the surface against adsorption of biomolecular and polymeric nanoparticles. Adsorption of model particles, bovine serum albumin (BSA) and latex nanoparticle, were tested on the patterned surface. PFPE remarkably prevented the adsorption of both nanoparticles while considerable adsorption of nanoparticles was observed on the negatively charged carboxyl-terminated surface. This outcome suggests that PFPE is a promising coating material that can be exploited for anti-biofouling.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
JournalJournal of Industrial and Engineering Chemistry
Volume17
Issue number2
DOIs
Publication statusPublished - 2011 Mar 25

Fingerprint

Nanoparticles
Proteins
Adsorption
Biofouling
Fluorine containing polymers
Latex
Hydrophobicity
Bovine Serum Albumin
Latexes
Interfacial energy
Particles (particulate matter)
perfluoropolyether
Coatings

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)

Cite this

@article{a2ca393a9f1246f985a7af6e7cb0c0ac,
title = "Prevention of protein and polymeric nanoparticles adsorption using perfluoropolyether",
abstract = "A fluoropolymer, perfluoropolyether (PFPE) was examined as an anti-adsorbing material that prevents protein and nanoparticle adsorption. PFPE has a fluoroalkyl chain that has low surface energy with both hydrophobicity and oleophobicity. Exploiting these properties, selective adsorption of protein and polymeric nanoparticles was achieved on a micropatterned surface where PFPE passivated the surface against adsorption of biomolecular and polymeric nanoparticles. Adsorption of model particles, bovine serum albumin (BSA) and latex nanoparticle, were tested on the patterned surface. PFPE remarkably prevented the adsorption of both nanoparticles while considerable adsorption of nanoparticles was observed on the negatively charged carboxyl-terminated surface. This outcome suggests that PFPE is a promising coating material that can be exploited for anti-biofouling.",
author = "Sunil Kwon and Hyungtae Kim and Ha, {Jong Wook} and Lee, {Sang Yup}",
year = "2011",
month = "3",
day = "25",
doi = "10.1016/j.jiec.2011.02.018",
language = "English",
volume = "17",
pages = "259--263",
journal = "Journal of Industrial and Engineering Chemistry",
issn = "1226-086X",
publisher = "Korean Society of Industrial Engineering Chemistry",
number = "2",

}

Prevention of protein and polymeric nanoparticles adsorption using perfluoropolyether. / Kwon, Sunil; Kim, Hyungtae; Ha, Jong Wook; Lee, Sang Yup.

In: Journal of Industrial and Engineering Chemistry, Vol. 17, No. 2, 25.03.2011, p. 259-263.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prevention of protein and polymeric nanoparticles adsorption using perfluoropolyether

AU - Kwon, Sunil

AU - Kim, Hyungtae

AU - Ha, Jong Wook

AU - Lee, Sang Yup

PY - 2011/3/25

Y1 - 2011/3/25

N2 - A fluoropolymer, perfluoropolyether (PFPE) was examined as an anti-adsorbing material that prevents protein and nanoparticle adsorption. PFPE has a fluoroalkyl chain that has low surface energy with both hydrophobicity and oleophobicity. Exploiting these properties, selective adsorption of protein and polymeric nanoparticles was achieved on a micropatterned surface where PFPE passivated the surface against adsorption of biomolecular and polymeric nanoparticles. Adsorption of model particles, bovine serum albumin (BSA) and latex nanoparticle, were tested on the patterned surface. PFPE remarkably prevented the adsorption of both nanoparticles while considerable adsorption of nanoparticles was observed on the negatively charged carboxyl-terminated surface. This outcome suggests that PFPE is a promising coating material that can be exploited for anti-biofouling.

AB - A fluoropolymer, perfluoropolyether (PFPE) was examined as an anti-adsorbing material that prevents protein and nanoparticle adsorption. PFPE has a fluoroalkyl chain that has low surface energy with both hydrophobicity and oleophobicity. Exploiting these properties, selective adsorption of protein and polymeric nanoparticles was achieved on a micropatterned surface where PFPE passivated the surface against adsorption of biomolecular and polymeric nanoparticles. Adsorption of model particles, bovine serum albumin (BSA) and latex nanoparticle, were tested on the patterned surface. PFPE remarkably prevented the adsorption of both nanoparticles while considerable adsorption of nanoparticles was observed on the negatively charged carboxyl-terminated surface. This outcome suggests that PFPE is a promising coating material that can be exploited for anti-biofouling.

UR - http://www.scopus.com/inward/record.url?scp=79955636529&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955636529&partnerID=8YFLogxK

U2 - 10.1016/j.jiec.2011.02.018

DO - 10.1016/j.jiec.2011.02.018

M3 - Article

AN - SCOPUS:79955636529

VL - 17

SP - 259

EP - 263

JO - Journal of Industrial and Engineering Chemistry

JF - Journal of Industrial and Engineering Chemistry

SN - 1226-086X

IS - 2

ER -