Preventive effect of human acellular dermal matrix on post-thyroidectomy scars and adhesions

A randomized, double-blinded, controlled trial

Do Young Kim, Sang Wook Kang, Dae Suk Kim, Jung U. Shin, Woong Youn Chung, Cheong Soo Park, JuHee Lee, Kee Hyun Nam

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

BACKGROUND Acellular dermal matrix (ADM) has been used for antiadhesion formation along with wound healing in various surgical fields. OBJECTIVE The aim is to assess the efficacy of ADM implantation in the prevention of postoperative scars and adhesions after conventional, open, total thyroidectomy. MATERIALS AND METHODS Forty-four patients with papillary thyroid carcinoma undergoing thyroidectomy were randomly assigned to the study (ADM implantation) or control group (without ADM). Global photographic assessment, Vancouver scar scale (VSS), objective scar assessment, and swallowing impairment index were assessed at baseline, immediately after surgery, and at 1 and 2 months after surgery. RESULTS Nineteen control and 20 study group participants completed the study. The mean VSS score of the study group was significantly lower than the controls at both 1 month (3.06 ± 1.25 vs 4.41 ± 1.54, respectively) and 2 months (2.76 6 1.56 vs 4.35 6 1.58, respectively) after surgery. Scar quality measures (mean melanin and erythema indexes) were significantly lower in the study group compared with controls. Study group participants had significantly lower swallowing impairment scores than controls. The mean postoperative hospitalization of both groups was not significantly different. CONCLUSION Acellular dermal matrix-assisted implants appear to improve post-thyroidectomy scar and swallowing impairments without delays in operation time.

Original languageEnglish
Pages (from-to)812-820
Number of pages9
JournalDermatologic Surgery
Volume41
Issue number7
DOIs
Publication statusPublished - 2015 Jul 9

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Acellular Dermis
Thyroidectomy
Cicatrix
Deglutition
Hospitalization Insurance
Melanins
Erythema
Wound Healing
Control Groups

All Science Journal Classification (ASJC) codes

  • Surgery
  • Dermatology

Cite this

Kim, Do Young ; Kang, Sang Wook ; Kim, Dae Suk ; Shin, Jung U. ; Chung, Woong Youn ; Park, Cheong Soo ; Lee, JuHee ; Nam, Kee Hyun. / Preventive effect of human acellular dermal matrix on post-thyroidectomy scars and adhesions : A randomized, double-blinded, controlled trial. In: Dermatologic Surgery. 2015 ; Vol. 41, No. 7. pp. 812-820.
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title = "Preventive effect of human acellular dermal matrix on post-thyroidectomy scars and adhesions: A randomized, double-blinded, controlled trial",
abstract = "BACKGROUND Acellular dermal matrix (ADM) has been used for antiadhesion formation along with wound healing in various surgical fields. OBJECTIVE The aim is to assess the efficacy of ADM implantation in the prevention of postoperative scars and adhesions after conventional, open, total thyroidectomy. MATERIALS AND METHODS Forty-four patients with papillary thyroid carcinoma undergoing thyroidectomy were randomly assigned to the study (ADM implantation) or control group (without ADM). Global photographic assessment, Vancouver scar scale (VSS), objective scar assessment, and swallowing impairment index were assessed at baseline, immediately after surgery, and at 1 and 2 months after surgery. RESULTS Nineteen control and 20 study group participants completed the study. The mean VSS score of the study group was significantly lower than the controls at both 1 month (3.06 ± 1.25 vs 4.41 ± 1.54, respectively) and 2 months (2.76 6 1.56 vs 4.35 6 1.58, respectively) after surgery. Scar quality measures (mean melanin and erythema indexes) were significantly lower in the study group compared with controls. Study group participants had significantly lower swallowing impairment scores than controls. The mean postoperative hospitalization of both groups was not significantly different. CONCLUSION Acellular dermal matrix-assisted implants appear to improve post-thyroidectomy scar and swallowing impairments without delays in operation time.",
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Preventive effect of human acellular dermal matrix on post-thyroidectomy scars and adhesions : A randomized, double-blinded, controlled trial. / Kim, Do Young; Kang, Sang Wook; Kim, Dae Suk; Shin, Jung U.; Chung, Woong Youn; Park, Cheong Soo; Lee, JuHee; Nam, Kee Hyun.

In: Dermatologic Surgery, Vol. 41, No. 7, 09.07.2015, p. 812-820.

Research output: Contribution to journalArticle

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T1 - Preventive effect of human acellular dermal matrix on post-thyroidectomy scars and adhesions

T2 - A randomized, double-blinded, controlled trial

AU - Kim, Do Young

AU - Kang, Sang Wook

AU - Kim, Dae Suk

AU - Shin, Jung U.

AU - Chung, Woong Youn

AU - Park, Cheong Soo

AU - Lee, JuHee

AU - Nam, Kee Hyun

PY - 2015/7/9

Y1 - 2015/7/9

N2 - BACKGROUND Acellular dermal matrix (ADM) has been used for antiadhesion formation along with wound healing in various surgical fields. OBJECTIVE The aim is to assess the efficacy of ADM implantation in the prevention of postoperative scars and adhesions after conventional, open, total thyroidectomy. MATERIALS AND METHODS Forty-four patients with papillary thyroid carcinoma undergoing thyroidectomy were randomly assigned to the study (ADM implantation) or control group (without ADM). Global photographic assessment, Vancouver scar scale (VSS), objective scar assessment, and swallowing impairment index were assessed at baseline, immediately after surgery, and at 1 and 2 months after surgery. RESULTS Nineteen control and 20 study group participants completed the study. The mean VSS score of the study group was significantly lower than the controls at both 1 month (3.06 ± 1.25 vs 4.41 ± 1.54, respectively) and 2 months (2.76 6 1.56 vs 4.35 6 1.58, respectively) after surgery. Scar quality measures (mean melanin and erythema indexes) were significantly lower in the study group compared with controls. Study group participants had significantly lower swallowing impairment scores than controls. The mean postoperative hospitalization of both groups was not significantly different. CONCLUSION Acellular dermal matrix-assisted implants appear to improve post-thyroidectomy scar and swallowing impairments without delays in operation time.

AB - BACKGROUND Acellular dermal matrix (ADM) has been used for antiadhesion formation along with wound healing in various surgical fields. OBJECTIVE The aim is to assess the efficacy of ADM implantation in the prevention of postoperative scars and adhesions after conventional, open, total thyroidectomy. MATERIALS AND METHODS Forty-four patients with papillary thyroid carcinoma undergoing thyroidectomy were randomly assigned to the study (ADM implantation) or control group (without ADM). Global photographic assessment, Vancouver scar scale (VSS), objective scar assessment, and swallowing impairment index were assessed at baseline, immediately after surgery, and at 1 and 2 months after surgery. RESULTS Nineteen control and 20 study group participants completed the study. The mean VSS score of the study group was significantly lower than the controls at both 1 month (3.06 ± 1.25 vs 4.41 ± 1.54, respectively) and 2 months (2.76 6 1.56 vs 4.35 6 1.58, respectively) after surgery. Scar quality measures (mean melanin and erythema indexes) were significantly lower in the study group compared with controls. Study group participants had significantly lower swallowing impairment scores than controls. The mean postoperative hospitalization of both groups was not significantly different. CONCLUSION Acellular dermal matrix-assisted implants appear to improve post-thyroidectomy scar and swallowing impairments without delays in operation time.

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