Previous cerebrovascular disease is an important predictor of clinical outcomes in elderly patients with percutaneous coronary interventions: The nobori-biolimus eluting stent prospective multicenter 1-year observational registry in South Korea

Yong Hoon Kim, Ae Young Her, Byeong Keuk Kim, Dong Ho Shin, Jung Sun Kim, Young Guk Ko, Donghoon Choi, Myeongki Hong, Yangsoo Jang

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Abstract

Objective: The appropriate selection of elderly patients for revascularization has become increasingly important because these subsets of patients are more likely to experience a major cardiac or cerebrovascular event—percutaneous coronary intervention (PCI). The objective this study was to determine important independent risk factor for predicting clinical outcomes in the elderly patients after successful PCI, paticularly in a series of South Korean population. Methods: This study is prospective, multicenter, observational cross-sectional study. A total of 1,884 consecutive patients who underwent successful PCI with Nobori® Biolimus A9-eluting stents were enrolled between April 2010 and December 2012. They were divided into two groupaccording to the age: patients <75 years old (younger patient group) and ≥75 years old (elderly patient group). The primary endpoint was majoadverse cardiac or cerebrovascular events (MACCE) at 1-year after index PCI. Results: The 1-year cumulative incidence of MACCE (12.9% vs. 4.3%, p<0.001) and total death (7.1% vs. 1.5%, p<0.001) was significantly higher the elderly group than in younger group. Previous cerebrovascular disease was significantly correlated with MACCE in elderly patients 1-yeaafter PCI (hazard ratio, 2.804; 95% confidence interval, 1.290–6.093 p=0.009). Conclusion: Previous cerebrovascular disease is important independent predictor of the MACCE in elderly patients at 1-year after PCI witNobori® Biolimus A9-eluting stents especially in a series of South Korean population. Therefore, careful PCI with intensive monitoring and management can improve major clinical outcomes after successful PCI in elderly patients with previous cerebrovascular disease compared wityounger patients.

Original languageEnglish
Pages (from-to)128-135
Number of pages8
JournalAnatolian Journal of Cardiology
Volume18
Issue number2
DOIs
Publication statusPublished - 2017 Jan 1

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Cerebrovascular Disorders
Republic of Korea
Percutaneous Coronary Intervention
Stents
Registries
Patient Selection
Population
Cross-Sectional Studies
Prospective Studies
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{749da89c185b41a0a6fbe241fcc0a40c,
title = "Previous cerebrovascular disease is an important predictor of clinical outcomes in elderly patients with percutaneous coronary interventions: The nobori-biolimus eluting stent prospective multicenter 1-year observational registry in South Korea",
abstract = "Objective: The appropriate selection of elderly patients for revascularization has become increasingly important because these subsets of patients are more likely to experience a major cardiac or cerebrovascular event—percutaneous coronary intervention (PCI). The objective this study was to determine important independent risk factor for predicting clinical outcomes in the elderly patients after successful PCI, paticularly in a series of South Korean population. Methods: This study is prospective, multicenter, observational cross-sectional study. A total of 1,884 consecutive patients who underwent successful PCI with Nobori{\circledR} Biolimus A9-eluting stents were enrolled between April 2010 and December 2012. They were divided into two groupaccording to the age: patients <75 years old (younger patient group) and ≥75 years old (elderly patient group). The primary endpoint was majoadverse cardiac or cerebrovascular events (MACCE) at 1-year after index PCI. Results: The 1-year cumulative incidence of MACCE (12.9{\%} vs. 4.3{\%}, p<0.001) and total death (7.1{\%} vs. 1.5{\%}, p<0.001) was significantly higher the elderly group than in younger group. Previous cerebrovascular disease was significantly correlated with MACCE in elderly patients 1-yeaafter PCI (hazard ratio, 2.804; 95{\%} confidence interval, 1.290–6.093 p=0.009). Conclusion: Previous cerebrovascular disease is important independent predictor of the MACCE in elderly patients at 1-year after PCI witNobori{\circledR} Biolimus A9-eluting stents especially in a series of South Korean population. Therefore, careful PCI with intensive monitoring and management can improve major clinical outcomes after successful PCI in elderly patients with previous cerebrovascular disease compared wityounger patients.",
author = "Kim, {Yong Hoon} and Her, {Ae Young} and Kim, {Byeong Keuk} and Shin, {Dong Ho} and Kim, {Jung Sun} and Ko, {Young Guk} and Donghoon Choi and Myeongki Hong and Yangsoo Jang",
year = "2017",
month = "1",
day = "1",
doi = "10.14744/AnatolJCardiol.2017.7670",
language = "English",
volume = "18",
pages = "128--135",
journal = "Anatolian journal of cardiology",
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TY - JOUR

T1 - Previous cerebrovascular disease is an important predictor of clinical outcomes in elderly patients with percutaneous coronary interventions

T2 - The nobori-biolimus eluting stent prospective multicenter 1-year observational registry in South Korea

AU - Kim, Yong Hoon

AU - Her, Ae Young

AU - Kim, Byeong Keuk

AU - Shin, Dong Ho

AU - Kim, Jung Sun

AU - Ko, Young Guk

AU - Choi, Donghoon

AU - Hong, Myeongki

AU - Jang, Yangsoo

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objective: The appropriate selection of elderly patients for revascularization has become increasingly important because these subsets of patients are more likely to experience a major cardiac or cerebrovascular event—percutaneous coronary intervention (PCI). The objective this study was to determine important independent risk factor for predicting clinical outcomes in the elderly patients after successful PCI, paticularly in a series of South Korean population. Methods: This study is prospective, multicenter, observational cross-sectional study. A total of 1,884 consecutive patients who underwent successful PCI with Nobori® Biolimus A9-eluting stents were enrolled between April 2010 and December 2012. They were divided into two groupaccording to the age: patients <75 years old (younger patient group) and ≥75 years old (elderly patient group). The primary endpoint was majoadverse cardiac or cerebrovascular events (MACCE) at 1-year after index PCI. Results: The 1-year cumulative incidence of MACCE (12.9% vs. 4.3%, p<0.001) and total death (7.1% vs. 1.5%, p<0.001) was significantly higher the elderly group than in younger group. Previous cerebrovascular disease was significantly correlated with MACCE in elderly patients 1-yeaafter PCI (hazard ratio, 2.804; 95% confidence interval, 1.290–6.093 p=0.009). Conclusion: Previous cerebrovascular disease is important independent predictor of the MACCE in elderly patients at 1-year after PCI witNobori® Biolimus A9-eluting stents especially in a series of South Korean population. Therefore, careful PCI with intensive monitoring and management can improve major clinical outcomes after successful PCI in elderly patients with previous cerebrovascular disease compared wityounger patients.

AB - Objective: The appropriate selection of elderly patients for revascularization has become increasingly important because these subsets of patients are more likely to experience a major cardiac or cerebrovascular event—percutaneous coronary intervention (PCI). The objective this study was to determine important independent risk factor for predicting clinical outcomes in the elderly patients after successful PCI, paticularly in a series of South Korean population. Methods: This study is prospective, multicenter, observational cross-sectional study. A total of 1,884 consecutive patients who underwent successful PCI with Nobori® Biolimus A9-eluting stents were enrolled between April 2010 and December 2012. They were divided into two groupaccording to the age: patients <75 years old (younger patient group) and ≥75 years old (elderly patient group). The primary endpoint was majoadverse cardiac or cerebrovascular events (MACCE) at 1-year after index PCI. Results: The 1-year cumulative incidence of MACCE (12.9% vs. 4.3%, p<0.001) and total death (7.1% vs. 1.5%, p<0.001) was significantly higher the elderly group than in younger group. Previous cerebrovascular disease was significantly correlated with MACCE in elderly patients 1-yeaafter PCI (hazard ratio, 2.804; 95% confidence interval, 1.290–6.093 p=0.009). Conclusion: Previous cerebrovascular disease is important independent predictor of the MACCE in elderly patients at 1-year after PCI witNobori® Biolimus A9-eluting stents especially in a series of South Korean population. Therefore, careful PCI with intensive monitoring and management can improve major clinical outcomes after successful PCI in elderly patients with previous cerebrovascular disease compared wityounger patients.

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JO - Anatolian journal of cardiology

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