Primary mucinous cystadenocarcinoma of the breast: Cytologic finding and expression of MUC5 are different from mucinous carcinoma

Sung Eun Kim, Ji Hye Park, Soon Won Hong, Ja Seung Koo, Joon Jeong, Woo Hee Jung

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7 Citations (Scopus)

Abstract

Mucinous cystadenocarcinoma (MCA) in the breast is a rare neoplasm. There have been 13 cases of primary breast MCA reported. The MCA presents as a large, partially cystic mass in postmenopausal woman with a good prognosis. The microscopic findings resemble those of ovarian, pancreatic, or appendiceal MCA. The aspiration findings showed mucin-containing cell clusters in the background of mucin and necrotic material. The cell clusters had intracytoplasmic mucin displacing atypical nuclei to the periphery. Histologically, the tumor revealed an abundant mucin pool with small floating clusters of mucin-containing tumor cells. There were also small cysts lined by a single layer of tall columnar mucinous cells, resembling those of the uterine endocervix. The cancer cells were positive for mucin (MUC) 5 and negative for MUC2 and MUC6. This mucin profile is different from ordinary mucinous carcinoma and may be a unique characteristic of breast MCA.

Original languageEnglish
Pages (from-to)611-616
Number of pages6
JournalKorean Journal of Pathology
Volume46
Issue number6
DOIs
Publication statusPublished - 2012 Dec 1

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All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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