Abstract
Background/Aim: Peritoneal fluid (PF) cytology is critical for distinguishing high-grade serous carcinoma (HGSC) from metastatic disease in patients with breast carcinoma who present with peritoneal carcinomatosis (PC). Case Report: A 50-year-old woman underwent surgery and adjuvant therapy for pT1N0 grade 2/2 luminal A breast carcinoma. Sixteen months postoperatively, palliative chemotherapy was administered following a pleural biopsy and diagnosis of metastatic carcinoma. The patient developed PC despite chemotherapy. PF cytology specimens suggested metastatic carcinoma. However, we observed a papillary cellular arrangement during the review of cytology slides. HGSC was confirmed by immunocytochemistry showing positive paired box 8 (PAX8) and Wilms' tumor 1 (WT1) expression and negative GATA-binding protein 3 expression. Conclusion: In patients with breast carcinoma history, an awareness of characteristic cytomorphology of HGSC, including a papillary pattern with positive PAX8 and WT1 immunoreactivity, is essential to prevent the misdiagnosis of such cases and in ensuring accurate treatment and management.
| Original language | English |
|---|---|
| Pages (from-to) | 2933-2939 |
| Number of pages | 7 |
| Journal | Anticancer research |
| Volume | 40 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2020 May |
Bibliographical note
Funding Information:This research was supported by a grant from the National Research Foundation of Korea (NRF), funded by the Korean government (MSIT) (2018R1C1B5043725). All Authors would like to thank Dr. Sung-Im Do (Department of Pathology, Kangbuk Samsung Hospital, Seoul, Republic of Korea) for her valuable comments and support.
Publisher Copyright:
© 2020 International Institute of Anticancer Research. All rights reserved.
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
