Primary thyroid mucosa-associated lymphoid tissue lymphoma; a clinicopathological study of seven cases

Seung Chul Lee, Soon Won Hong, Yong Sang Lee, Jong Ju Jeong, Kee Hyun Nam, Woong Youn Chung, Hang-Seok Chang, Cheong Soo Park

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: Primary thyroid mucosa-associated lymphoid tissue (MALT) lymphoma is a very rare subgroup of thyroid lymphoma, accounting for about 6 to 28% of all primary thyroid lymphomas. The purpose of this study was to evaluate its clinicopathological features and treatment outcomes. Methods: We identified seven patients with thyroid MALT lymphoma who were treated between January 1997 and December 2007, and reviewed their clinicopathological features and follow-up outcomes. Results: There were five female and two male patients, and their mean age was 73 years. All patients presented with palpable neck mass. Two patients had hoarseness and dyspnea. All patients had a history of Hashimoto's thyroiditis with a mean of 175 months. Malignant lymphoma was suspected in only three patients using core needle biopsy. Four patients underwent thyroidectomy in the absence of preoperative pathologic confirmation, and histologic diagnosis was obtained after surgery. As initial treatment, complete surgical resection was performed in five patients, radiotherapy in one, and a combination of chemotherapy and radiotherapy in one. Six patients were alive for the mean follow-up period of 66 months and one patient died of unrelated causes. There were neither recurrences nor disease-specific mortalities. Conclusion: When primary thyroid MALT lymphoma occurs in the thyroid or is confined to the neck, it responds well to local treatment such as surgical resection and external beam radiation therapy.

Original languageEnglish
Pages (from-to)374-379
Number of pages6
JournalJournal of the Korean Surgical Society
Volume81
Issue number6
DOIs
Publication statusPublished - 2011 Dec 1

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Marginal Zone B-Cell Lymphoma
Thyroid Gland
Lymphoma
Radiotherapy
Neck
Large-Core Needle Biopsy
Hoarseness
Hashimoto Disease
Thyroidectomy
Combination Drug Therapy
Dyspnea
Recurrence

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Lee, Seung Chul ; Hong, Soon Won ; Lee, Yong Sang ; Jeong, Jong Ju ; Nam, Kee Hyun ; Chung, Woong Youn ; Chang, Hang-Seok ; Park, Cheong Soo. / Primary thyroid mucosa-associated lymphoid tissue lymphoma; a clinicopathological study of seven cases. In: Journal of the Korean Surgical Society. 2011 ; Vol. 81, No. 6. pp. 374-379.
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Primary thyroid mucosa-associated lymphoid tissue lymphoma; a clinicopathological study of seven cases. / Lee, Seung Chul; Hong, Soon Won; Lee, Yong Sang; Jeong, Jong Ju; Nam, Kee Hyun; Chung, Woong Youn; Chang, Hang-Seok; Park, Cheong Soo.

In: Journal of the Korean Surgical Society, Vol. 81, No. 6, 01.12.2011, p. 374-379.

Research output: Contribution to journalArticle

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