We analyze sensing performances of localized surface plasmon resonance biosensors based on the overlap between target distribution and local field intensity produced by silver nanoislands in three detection models of non-specific, non-colocalized, and colocalized detection. The behavior of biomolecules was modeled to follow a probabilistic model using Poisson distribution. The results have found that the colocalized detection achieves the highest overlap signature with the smallest uncertainty and can enhance the limit of detection by more than 10000 times compared to conventional non-specific detection.
|Title of host publication||International Conference on Nano-Bio Sensing, Imaging, and Spectroscopy 2015, NBSIS 2015|
|Editors||Donghyun Kim, Min-Gon Kim, Seung-Han Park|
|Publication status||Published - 2015|
|Event||2nd International Conference on Nano-Bio Sensing, Imaging, and Spectroscopy, NBSIS 2015 - Jeju, Korea, Republic of|
Duration: 2015 Feb 25 → 2015 Feb 27
|Name||Progress in Biomedical Optics and Imaging - Proceedings of SPIE|
|Other||2nd International Conference on Nano-Bio Sensing, Imaging, and Spectroscopy, NBSIS 2015|
|Country||Korea, Republic of|
|Period||15/2/25 → 15/2/27|
Bibliographical notePublisher Copyright:
© 2015 SPIE.
All Science Journal Classification (ASJC) codes
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
- Radiology Nuclear Medicine and imaging