Profiles of extrapulmonary nontuberculous mycobacteria infections and predictors for species: A multicenter retrospective study

Jung Ho Kim, In Young Jung, Je Eun Song, Eun Jin Kim, Jun Hyoung Kim, Woon Ji Lee, Hye Seong, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Jun Yong Choi, Joon Sup Yeom, Young Goo Song

Research output: Contribution to journalArticlepeer-review

Abstract

Extrapulmonary nontuberculous mycobacteria (NTM) infections contribute to morbidity and mortality worldwide. However, studies about extrapulmonary NTM infections have been limited. Therefore, we aim to describe the diversity of extrapulmonary NTM infections and identify predictors for species. Information regarding diversity of NTM isolates, antimicrobial susceptibility testing, treatment regimens, and outcomes were collected from four tertiary care centers in South Korea. Comparisons were made between patients with rapidly growing mycobacteria (RGM) and slowly growing mycobacteria (SGM) infections. A total of 117 patients (46 males vs. 71 females) were included. Skin and soft tissue infections (SSTIs) predominated (34.2%), followed by bone and joint infections (28.2%). In SSTIs, RGM species were predominantly identified (26/28, 92.9%), whereas SGM species were mainly identified in bone and joint infections (18/26, 69.2%), and the difference of isolated sites was verified by a post hoc test (p < 0.001). Multivariable regression analysis revealed that male sex (vs. female sex; OR 5.30, CI 1.35–24.26, p = 0.020) and bone and joint infections (vs. SSTIs; OR 18.10, CI 3.28–157.07, p = 0.002) were predictors of SGM infections, whereas the opposite was observed for RGM infections. Bone and joint infections and male sex were predictors for SGM infections, whereas SSTIs and female sex were predictors for RGM infections.

Original languageEnglish
Article number949
Pages (from-to)1-12
Number of pages12
JournalPathogens
Volume9
Issue number11
DOIs
Publication statusPublished - 2020 Nov

Bibliographical note

Publisher Copyright:
© 2020 by the authors.

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Molecular Biology
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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