Prognostic effect of perioperative change of serum carcinoembryonic antigen level

A useful tool for detection of systemic recurrence in rectal cancer

Yoon Ah Park, Young Lee Kang, Namkyu Kim, Hyuk Baik Seung, Kook Sohn Seung, Whan Cho Chang

Research output: Contribution to journalReview article

67 Citations (Scopus)

Abstract

Background: The prognosis of patients even with the same stage of rectal cancer varies widely. We analyzed the capability of perioperative change of serum carcinoembryonic antigen (CEA) level for predicting recurrence and survival in rectal cancer patients. Methods: We reviewed 631 patients who underwent potentially curative resection for stage II or III rectal cancer. Patients were categorized into three groups according to their serum CEA concentrations on the seventh day before and on the seventh day after surgery: group A, normal CEA level (≤5 ng/mL) in both periods; group B, increased preoperative and normal postoperative CEA; and group C, continuously increased CEA in both periods. The prognostic relevance of the CEA group was investigated by analyses of recurrence patterns and survival. Results: Stage III patients showed higher systemic recurrence (P = .001) and worse 5-year survival rates (P < .0001) for group C than for groups A and B. On multivariate analysis, the CEA group was a significant predictor for recurrence (P < .001; relative risk, 2.740; 95% confidence interval, 1.677-4.476) and survival (P = .001; relative risk, 2.174; 95% confidence interval, 1.556-3.308). Conclusions: The perioperative serum CEA change was a useful prognostic indicator to predict for systemic recurrence and survival in stage III rectal cancer patients.

Original languageEnglish
Pages (from-to)645-650
Number of pages6
JournalAnnals of Surgical Oncology
Volume13
Issue number5
DOIs
Publication statusPublished - 2006 May 1

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Carcinoembryonic Antigen
Rectal Neoplasms
Recurrence
Serum
Survival
Confidence Intervals
Ambulatory Surgical Procedures
Multivariate Analysis
Survival Rate

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Park, Yoon Ah ; Kang, Young Lee ; Kim, Namkyu ; Seung, Hyuk Baik ; Seung, Kook Sohn ; Chang, Whan Cho. / Prognostic effect of perioperative change of serum carcinoembryonic antigen level : A useful tool for detection of systemic recurrence in rectal cancer. In: Annals of Surgical Oncology. 2006 ; Vol. 13, No. 5. pp. 645-650.
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title = "Prognostic effect of perioperative change of serum carcinoembryonic antigen level: A useful tool for detection of systemic recurrence in rectal cancer",
abstract = "Background: The prognosis of patients even with the same stage of rectal cancer varies widely. We analyzed the capability of perioperative change of serum carcinoembryonic antigen (CEA) level for predicting recurrence and survival in rectal cancer patients. Methods: We reviewed 631 patients who underwent potentially curative resection for stage II or III rectal cancer. Patients were categorized into three groups according to their serum CEA concentrations on the seventh day before and on the seventh day after surgery: group A, normal CEA level (≤5 ng/mL) in both periods; group B, increased preoperative and normal postoperative CEA; and group C, continuously increased CEA in both periods. The prognostic relevance of the CEA group was investigated by analyses of recurrence patterns and survival. Results: Stage III patients showed higher systemic recurrence (P = .001) and worse 5-year survival rates (P < .0001) for group C than for groups A and B. On multivariate analysis, the CEA group was a significant predictor for recurrence (P < .001; relative risk, 2.740; 95{\%} confidence interval, 1.677-4.476) and survival (P = .001; relative risk, 2.174; 95{\%} confidence interval, 1.556-3.308). Conclusions: The perioperative serum CEA change was a useful prognostic indicator to predict for systemic recurrence and survival in stage III rectal cancer patients.",
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Prognostic effect of perioperative change of serum carcinoembryonic antigen level : A useful tool for detection of systemic recurrence in rectal cancer. / Park, Yoon Ah; Kang, Young Lee; Kim, Namkyu; Seung, Hyuk Baik; Seung, Kook Sohn; Chang, Whan Cho.

In: Annals of Surgical Oncology, Vol. 13, No. 5, 01.05.2006, p. 645-650.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Prognostic effect of perioperative change of serum carcinoembryonic antigen level

T2 - A useful tool for detection of systemic recurrence in rectal cancer

AU - Park, Yoon Ah

AU - Kang, Young Lee

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AU - Seung, Hyuk Baik

AU - Seung, Kook Sohn

AU - Chang, Whan Cho

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N2 - Background: The prognosis of patients even with the same stage of rectal cancer varies widely. We analyzed the capability of perioperative change of serum carcinoembryonic antigen (CEA) level for predicting recurrence and survival in rectal cancer patients. Methods: We reviewed 631 patients who underwent potentially curative resection for stage II or III rectal cancer. Patients were categorized into three groups according to their serum CEA concentrations on the seventh day before and on the seventh day after surgery: group A, normal CEA level (≤5 ng/mL) in both periods; group B, increased preoperative and normal postoperative CEA; and group C, continuously increased CEA in both periods. The prognostic relevance of the CEA group was investigated by analyses of recurrence patterns and survival. Results: Stage III patients showed higher systemic recurrence (P = .001) and worse 5-year survival rates (P < .0001) for group C than for groups A and B. On multivariate analysis, the CEA group was a significant predictor for recurrence (P < .001; relative risk, 2.740; 95% confidence interval, 1.677-4.476) and survival (P = .001; relative risk, 2.174; 95% confidence interval, 1.556-3.308). Conclusions: The perioperative serum CEA change was a useful prognostic indicator to predict for systemic recurrence and survival in stage III rectal cancer patients.

AB - Background: The prognosis of patients even with the same stage of rectal cancer varies widely. We analyzed the capability of perioperative change of serum carcinoembryonic antigen (CEA) level for predicting recurrence and survival in rectal cancer patients. Methods: We reviewed 631 patients who underwent potentially curative resection for stage II or III rectal cancer. Patients were categorized into three groups according to their serum CEA concentrations on the seventh day before and on the seventh day after surgery: group A, normal CEA level (≤5 ng/mL) in both periods; group B, increased preoperative and normal postoperative CEA; and group C, continuously increased CEA in both periods. The prognostic relevance of the CEA group was investigated by analyses of recurrence patterns and survival. Results: Stage III patients showed higher systemic recurrence (P = .001) and worse 5-year survival rates (P < .0001) for group C than for groups A and B. On multivariate analysis, the CEA group was a significant predictor for recurrence (P < .001; relative risk, 2.740; 95% confidence interval, 1.677-4.476) and survival (P = .001; relative risk, 2.174; 95% confidence interval, 1.556-3.308). Conclusions: The perioperative serum CEA change was a useful prognostic indicator to predict for systemic recurrence and survival in stage III rectal cancer patients.

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