Prognostic factor analysis in patients with metastatic spine disease depending on surgery and conservative treatment: Review of 577 cases

Byung Ho Lee, Tae Hwan Kim, Hyun Soo Chong, Eun Soo Moon, Jin Oh Park, Hak Sun Kim, Seung Hyun Kim, Hwan Mo Lee, Yong Jin Cho, Keung Nyun Kim, Seong Hwan Moon

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29 Citations (Scopus)

Abstract

Background: To date, skillful medical management and advanced surgical techniques have provided increased quality of life with less postoperative morbidity in patients with spinal metastasis. We assessed the survival of patients with spinal metastasis according to two treatment modalities: surgery and conservative treatment. Methods: From 2005 to 2010, a total of 577 patients (200 surgery, 377 conservative treatment) who had spinal metastasis were enrolled. Prognostic factors and survival were assessed by Cox regression and Kaplan-Meier analyses in patients receiving either surgery or conservative treatment. Results: The mean age was 59.7 (range 21-87) years in the surgery group and 59.9 (range 28-90) years in the conservative treatment group. The major primary cancers were of lung, liver, and colorectal origin in the surgery group and lung, liver, and breast in the conservative group. The mean ± SD Tokuhashi score in the surgery group was 8.12 ± 3.09 and in the conservative group was 8.0 ± 2.8 (not significant). The hazard ratio of the primary cancer group ranged from 1.870 to 3.217 compared to that of the most favorable primary cancer group in all patients. Survival was affected significantly by sex, adjuvant therapy, and postoperative survival in the surgery group and by clinical symptom, metastasis to major internal organ, and primary cancer origin in the conservative group. Conclusions: With this retrospective review of 577 cases of spinal metastasis, different prognostic factors depending on the treatment modality were discovered. Hence, consideration of these factors depending on the treatment modality could be helpful in treating patients with spinal metastasis.

Original languageEnglish
Pages (from-to)40-46
Number of pages7
JournalAnnals of Surgical Oncology
Volume20
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

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Statistical Factor Analysis
Spine
Neoplasm Metastasis
Survival
Neoplasms
Liver
Kaplan-Meier Estimate
Therapeutics
Conservative Treatment
Lung Neoplasms
Breast
Quality of Life
Morbidity
Lung

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Lee, Byung Ho ; Kim, Tae Hwan ; Chong, Hyun Soo ; Moon, Eun Soo ; Park, Jin Oh ; Kim, Hak Sun ; Kim, Seung Hyun ; Lee, Hwan Mo ; Cho, Yong Jin ; Kim, Keung Nyun ; Moon, Seong Hwan. / Prognostic factor analysis in patients with metastatic spine disease depending on surgery and conservative treatment : Review of 577 cases. In: Annals of Surgical Oncology. 2013 ; Vol. 20, No. 1. pp. 40-46.
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abstract = "Background: To date, skillful medical management and advanced surgical techniques have provided increased quality of life with less postoperative morbidity in patients with spinal metastasis. We assessed the survival of patients with spinal metastasis according to two treatment modalities: surgery and conservative treatment. Methods: From 2005 to 2010, a total of 577 patients (200 surgery, 377 conservative treatment) who had spinal metastasis were enrolled. Prognostic factors and survival were assessed by Cox regression and Kaplan-Meier analyses in patients receiving either surgery or conservative treatment. Results: The mean age was 59.7 (range 21-87) years in the surgery group and 59.9 (range 28-90) years in the conservative treatment group. The major primary cancers were of lung, liver, and colorectal origin in the surgery group and lung, liver, and breast in the conservative group. The mean ± SD Tokuhashi score in the surgery group was 8.12 ± 3.09 and in the conservative group was 8.0 ± 2.8 (not significant). The hazard ratio of the primary cancer group ranged from 1.870 to 3.217 compared to that of the most favorable primary cancer group in all patients. Survival was affected significantly by sex, adjuvant therapy, and postoperative survival in the surgery group and by clinical symptom, metastasis to major internal organ, and primary cancer origin in the conservative group. Conclusions: With this retrospective review of 577 cases of spinal metastasis, different prognostic factors depending on the treatment modality were discovered. Hence, consideration of these factors depending on the treatment modality could be helpful in treating patients with spinal metastasis.",
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Prognostic factor analysis in patients with metastatic spine disease depending on surgery and conservative treatment : Review of 577 cases. / Lee, Byung Ho; Kim, Tae Hwan; Chong, Hyun Soo; Moon, Eun Soo; Park, Jin Oh; Kim, Hak Sun; Kim, Seung Hyun; Lee, Hwan Mo; Cho, Yong Jin; Kim, Keung Nyun; Moon, Seong Hwan.

In: Annals of Surgical Oncology, Vol. 20, No. 1, 01.01.2013, p. 40-46.

Research output: Contribution to journalArticle

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AU - Moon, Eun Soo

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N2 - Background: To date, skillful medical management and advanced surgical techniques have provided increased quality of life with less postoperative morbidity in patients with spinal metastasis. We assessed the survival of patients with spinal metastasis according to two treatment modalities: surgery and conservative treatment. Methods: From 2005 to 2010, a total of 577 patients (200 surgery, 377 conservative treatment) who had spinal metastasis were enrolled. Prognostic factors and survival were assessed by Cox regression and Kaplan-Meier analyses in patients receiving either surgery or conservative treatment. Results: The mean age was 59.7 (range 21-87) years in the surgery group and 59.9 (range 28-90) years in the conservative treatment group. The major primary cancers were of lung, liver, and colorectal origin in the surgery group and lung, liver, and breast in the conservative group. The mean ± SD Tokuhashi score in the surgery group was 8.12 ± 3.09 and in the conservative group was 8.0 ± 2.8 (not significant). The hazard ratio of the primary cancer group ranged from 1.870 to 3.217 compared to that of the most favorable primary cancer group in all patients. Survival was affected significantly by sex, adjuvant therapy, and postoperative survival in the surgery group and by clinical symptom, metastasis to major internal organ, and primary cancer origin in the conservative group. Conclusions: With this retrospective review of 577 cases of spinal metastasis, different prognostic factors depending on the treatment modality were discovered. Hence, consideration of these factors depending on the treatment modality could be helpful in treating patients with spinal metastasis.

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