Prognostic factors affecting oncologic outcomes in patients with locally recurrent rectal cancer: Impact of patterns of pelvic recurrence on curative resection

Jea Kun Park, Young Wan Kim, Hyuk Hur, Nam Kyu Kim, Byung Soh Min, Seung Kook Sohn, Young Deuk Choi, Young Tae Kim, Jung Bai Ahn, Jae Kyung Roh, Ki Chang Keum, Jin Sil Seong

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Abstract

Background: The purpose of this study is to investigate prognostic factors affecting oncologic outcomes in patients with locally recurrent rectal cancer and determine whether recurrence patterns influence curative resection of recurrent tumor. Materials and methods: We examined 62 patients with isolated local recurrence following total mesorectal excision (TME) of the primary rectal cancer. Recurrence patterns were classified as central, anterior, posterior, lateral, and perineal with respect to the intra-pelvic tumor location. Prognostic factors affecting oncologic outcomes were analyzed, and the rate of curative resection was analyzed according to recurrence patterns. Results: The mean follow-up period was 49.0 ± 29.0 months, and the mean time to recurrence after TME was 27.9 ± 23.3 months. Twenty-three patients underwent curative resection, and the remaining 39 patients received palliative treatment. Patients with a central recurrence had the highest rate of curative resection (p = 0.006). The overall 5-year survival rate was 13.9% and significantly higher in those treated with curative resection (35.1%; p = 0.0002). Multivariate analysis demonstrated that disease-free survival less than 1 year and curative resection of local recurrence were independent prognostic factors influencing 5-year survival. Conclusion: Patients with central recurrences have a high probability of curative resection. Disease-free survival less than 1 year and curative resection of local recurrence were independent prognostic factors affecting oncologic outcomes in patients with locally recurrent rectal cancer.

Original languageEnglish
Pages (from-to)71-77
Number of pages7
JournalLangenbeck's Archives of Surgery
Volume394
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1

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Rectal Neoplasms
Recurrence
Disease-Free Survival
Palliative Care
Neoplasms
Multivariate Analysis
Survival Rate
Survival

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

@article{30ba149807474604921879067d07167c,
title = "Prognostic factors affecting oncologic outcomes in patients with locally recurrent rectal cancer: Impact of patterns of pelvic recurrence on curative resection",
abstract = "Background: The purpose of this study is to investigate prognostic factors affecting oncologic outcomes in patients with locally recurrent rectal cancer and determine whether recurrence patterns influence curative resection of recurrent tumor. Materials and methods: We examined 62 patients with isolated local recurrence following total mesorectal excision (TME) of the primary rectal cancer. Recurrence patterns were classified as central, anterior, posterior, lateral, and perineal with respect to the intra-pelvic tumor location. Prognostic factors affecting oncologic outcomes were analyzed, and the rate of curative resection was analyzed according to recurrence patterns. Results: The mean follow-up period was 49.0 ± 29.0 months, and the mean time to recurrence after TME was 27.9 ± 23.3 months. Twenty-three patients underwent curative resection, and the remaining 39 patients received palliative treatment. Patients with a central recurrence had the highest rate of curative resection (p = 0.006). The overall 5-year survival rate was 13.9{\%} and significantly higher in those treated with curative resection (35.1{\%}; p = 0.0002). Multivariate analysis demonstrated that disease-free survival less than 1 year and curative resection of local recurrence were independent prognostic factors influencing 5-year survival. Conclusion: Patients with central recurrences have a high probability of curative resection. Disease-free survival less than 1 year and curative resection of local recurrence were independent prognostic factors affecting oncologic outcomes in patients with locally recurrent rectal cancer.",
author = "Park, {Jea Kun} and Kim, {Young Wan} and Hyuk Hur and Kim, {Nam Kyu} and Min, {Byung Soh} and Sohn, {Seung Kook} and Choi, {Young Deuk} and Kim, {Young Tae} and Ahn, {Jung Bai} and Roh, {Jae Kyung} and Keum, {Ki Chang} and Seong, {Jin Sil}",
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Prognostic factors affecting oncologic outcomes in patients with locally recurrent rectal cancer : Impact of patterns of pelvic recurrence on curative resection. / Park, Jea Kun; Kim, Young Wan; Hur, Hyuk; Kim, Nam Kyu; Min, Byung Soh; Sohn, Seung Kook; Choi, Young Deuk; Kim, Young Tae; Ahn, Jung Bai; Roh, Jae Kyung; Keum, Ki Chang; Seong, Jin Sil.

In: Langenbeck's Archives of Surgery, Vol. 394, No. 1, 01.01.2009, p. 71-77.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostic factors affecting oncologic outcomes in patients with locally recurrent rectal cancer

T2 - Impact of patterns of pelvic recurrence on curative resection

AU - Park, Jea Kun

AU - Kim, Young Wan

AU - Hur, Hyuk

AU - Kim, Nam Kyu

AU - Min, Byung Soh

AU - Sohn, Seung Kook

AU - Choi, Young Deuk

AU - Kim, Young Tae

AU - Ahn, Jung Bai

AU - Roh, Jae Kyung

AU - Keum, Ki Chang

AU - Seong, Jin Sil

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Background: The purpose of this study is to investigate prognostic factors affecting oncologic outcomes in patients with locally recurrent rectal cancer and determine whether recurrence patterns influence curative resection of recurrent tumor. Materials and methods: We examined 62 patients with isolated local recurrence following total mesorectal excision (TME) of the primary rectal cancer. Recurrence patterns were classified as central, anterior, posterior, lateral, and perineal with respect to the intra-pelvic tumor location. Prognostic factors affecting oncologic outcomes were analyzed, and the rate of curative resection was analyzed according to recurrence patterns. Results: The mean follow-up period was 49.0 ± 29.0 months, and the mean time to recurrence after TME was 27.9 ± 23.3 months. Twenty-three patients underwent curative resection, and the remaining 39 patients received palliative treatment. Patients with a central recurrence had the highest rate of curative resection (p = 0.006). The overall 5-year survival rate was 13.9% and significantly higher in those treated with curative resection (35.1%; p = 0.0002). Multivariate analysis demonstrated that disease-free survival less than 1 year and curative resection of local recurrence were independent prognostic factors influencing 5-year survival. Conclusion: Patients with central recurrences have a high probability of curative resection. Disease-free survival less than 1 year and curative resection of local recurrence were independent prognostic factors affecting oncologic outcomes in patients with locally recurrent rectal cancer.

AB - Background: The purpose of this study is to investigate prognostic factors affecting oncologic outcomes in patients with locally recurrent rectal cancer and determine whether recurrence patterns influence curative resection of recurrent tumor. Materials and methods: We examined 62 patients with isolated local recurrence following total mesorectal excision (TME) of the primary rectal cancer. Recurrence patterns were classified as central, anterior, posterior, lateral, and perineal with respect to the intra-pelvic tumor location. Prognostic factors affecting oncologic outcomes were analyzed, and the rate of curative resection was analyzed according to recurrence patterns. Results: The mean follow-up period was 49.0 ± 29.0 months, and the mean time to recurrence after TME was 27.9 ± 23.3 months. Twenty-three patients underwent curative resection, and the remaining 39 patients received palliative treatment. Patients with a central recurrence had the highest rate of curative resection (p = 0.006). The overall 5-year survival rate was 13.9% and significantly higher in those treated with curative resection (35.1%; p = 0.0002). Multivariate analysis demonstrated that disease-free survival less than 1 year and curative resection of local recurrence were independent prognostic factors influencing 5-year survival. Conclusion: Patients with central recurrences have a high probability of curative resection. Disease-free survival less than 1 year and curative resection of local recurrence were independent prognostic factors affecting oncologic outcomes in patients with locally recurrent rectal cancer.

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U2 - 10.1007/s00423-008-0391-6

DO - 10.1007/s00423-008-0391-6

M3 - Article

C2 - 18663464

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VL - 394

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EP - 77

JO - Langenbeck's Archives of Surgery

JF - Langenbeck's Archives of Surgery

SN - 1435-2443

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