Prognostic Factors and 10-Year Survival in Patients with Hepatocellular Carcinoma After Curative Hepatectomy

Sung Hoon Kim, Sae Byeol Choi, JaeGil Lee, Seungup Kim, Mi Suk Park, doyoung kim, Jin Sub Choi, Kyung Sik Kim

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Abstract

Purpose: There were contrary results about the effects of hepatitis B e antigen (HBeAg) positivity on the long-term survival in patients with hepatocellular carcinoma (HCC) after curative resection. Patients and Methods: Medical records of 170 HCC patients who underwent curative liver resections were retrospectively reviewed. The 10-year survival rate and correlations among clinical, laboratory, and pathological data, especially HBeAg, were analyzed. Results: Fifty-two patients survived more than 10 years. The 10-year actual overall survival (OS) rate was 30.6%, and the actual disease-free survival (DFS) rate was 24. 1%. The median OS and DFS were 76 and 35 months, respectively. In multivariate analysis, HBeAg positivity (P = 0.032; hazard ratio [HR], 3.041), presence of a satellite nodule (P = 0.007; HR, 4.166), and elevated ICG R15 (P = 0.003; HR, 4.915) had a significant negative correlation with the 10-year DFS rate. In addition, HBeAg positivity (P = 0.044; HR, 3.725) and recurrence (recur within 1 year, P < 0.001; HR, 41.296; recur after 1 year, P = 0.03; HR, 4.848) were found as independent factors which were negatively correlated to the 10-year OS. Conclusions: The presence of HBeAg was significantly correlated to DFS and OS after curative resection for HCC. Active treatment of B viral hepatitis before and after surgery should be provided to prolong survival in patients with 5-10-cm HCC.

Original languageEnglish
Pages (from-to)598-607
Number of pages10
JournalJournal of Gastrointestinal Surgery
Volume15
Issue number4
DOIs
Publication statusPublished - 2011 Apr 1

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Hepatitis B e Antigens
Hepatectomy
Hepatocellular Carcinoma
Disease-Free Survival
Survival Rate
Survival
Hepatitis B
Medical Records
Multivariate Analysis
Recurrence
Liver

All Science Journal Classification (ASJC) codes

  • Surgery
  • Gastroenterology

Cite this

Kim, Sung Hoon ; Choi, Sae Byeol ; Lee, JaeGil ; Kim, Seungup ; Park, Mi Suk ; kim, doyoung ; Choi, Jin Sub ; Kim, Kyung Sik. / Prognostic Factors and 10-Year Survival in Patients with Hepatocellular Carcinoma After Curative Hepatectomy. In: Journal of Gastrointestinal Surgery. 2011 ; Vol. 15, No. 4. pp. 598-607.
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abstract = "Purpose: There were contrary results about the effects of hepatitis B e antigen (HBeAg) positivity on the long-term survival in patients with hepatocellular carcinoma (HCC) after curative resection. Patients and Methods: Medical records of 170 HCC patients who underwent curative liver resections were retrospectively reviewed. The 10-year survival rate and correlations among clinical, laboratory, and pathological data, especially HBeAg, were analyzed. Results: Fifty-two patients survived more than 10 years. The 10-year actual overall survival (OS) rate was 30.6{\%}, and the actual disease-free survival (DFS) rate was 24. 1{\%}. The median OS and DFS were 76 and 35 months, respectively. In multivariate analysis, HBeAg positivity (P = 0.032; hazard ratio [HR], 3.041), presence of a satellite nodule (P = 0.007; HR, 4.166), and elevated ICG R15 (P = 0.003; HR, 4.915) had a significant negative correlation with the 10-year DFS rate. In addition, HBeAg positivity (P = 0.044; HR, 3.725) and recurrence (recur within 1 year, P < 0.001; HR, 41.296; recur after 1 year, P = 0.03; HR, 4.848) were found as independent factors which were negatively correlated to the 10-year OS. Conclusions: The presence of HBeAg was significantly correlated to DFS and OS after curative resection for HCC. Active treatment of B viral hepatitis before and after surgery should be provided to prolong survival in patients with 5-10-cm HCC.",
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Prognostic Factors and 10-Year Survival in Patients with Hepatocellular Carcinoma After Curative Hepatectomy. / Kim, Sung Hoon; Choi, Sae Byeol; Lee, JaeGil; Kim, Seungup; Park, Mi Suk; kim, doyoung; Choi, Jin Sub; Kim, Kyung Sik.

In: Journal of Gastrointestinal Surgery, Vol. 15, No. 4, 01.04.2011, p. 598-607.

Research output: Contribution to journalArticle

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AU - Kim, Sung Hoon

AU - Choi, Sae Byeol

AU - Lee, JaeGil

AU - Kim, Seungup

AU - Park, Mi Suk

AU - kim, doyoung

AU - Choi, Jin Sub

AU - Kim, Kyung Sik

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N2 - Purpose: There were contrary results about the effects of hepatitis B e antigen (HBeAg) positivity on the long-term survival in patients with hepatocellular carcinoma (HCC) after curative resection. Patients and Methods: Medical records of 170 HCC patients who underwent curative liver resections were retrospectively reviewed. The 10-year survival rate and correlations among clinical, laboratory, and pathological data, especially HBeAg, were analyzed. Results: Fifty-two patients survived more than 10 years. The 10-year actual overall survival (OS) rate was 30.6%, and the actual disease-free survival (DFS) rate was 24. 1%. The median OS and DFS were 76 and 35 months, respectively. In multivariate analysis, HBeAg positivity (P = 0.032; hazard ratio [HR], 3.041), presence of a satellite nodule (P = 0.007; HR, 4.166), and elevated ICG R15 (P = 0.003; HR, 4.915) had a significant negative correlation with the 10-year DFS rate. In addition, HBeAg positivity (P = 0.044; HR, 3.725) and recurrence (recur within 1 year, P < 0.001; HR, 41.296; recur after 1 year, P = 0.03; HR, 4.848) were found as independent factors which were negatively correlated to the 10-year OS. Conclusions: The presence of HBeAg was significantly correlated to DFS and OS after curative resection for HCC. Active treatment of B viral hepatitis before and after surgery should be provided to prolong survival in patients with 5-10-cm HCC.

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