Prognostic Factors and Clinical Outcomes of High-Dose Chemotherapy followed by Autologous Stem Cell Transplantation in Patients with Peripheral T Cell Lymphoma, Unspecified

Complete Remission at Transplantation and the Prognostic Index of Peripheral T Cell Lymphoma Are the Major Factors Predictive of Outcome

Deok Hwan Yang, Won Seog Kim, Seok Jin Kim, Sung Hwa Bae, Sung Hyun Kim, In Ho Kim, Sung Soo Yoon, Yeung Chul Mun, Ho Jin Shin, Yee Soo Chae, Jae Yong Kwak, Hawk Kim, Min Kyoung Kim, Jinseok Kim, Jong Ho Won, Je Jung Lee, Cheol Won Suh

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

High-dose chemotherapy followed by autologous stem cell transplantation (HDT/ASCT) offers a rescue option for T cell lymphoma patients with poor prognosis. However, the effectiveness of HDT/ASCT in patients with various peripheral T cell subtypes, optimal transplant timing, and the prognostic factors that predict better outcomes, have not been identified. We retrospectively investigated the clinical outcomes and prognostic factors for HDT/ASCT in 64 Korean patients with peripheral T cell lymphoma, unspecified (PTCL-U) between March 1995 and February 2007. The median age at transplantation was 44 years (range: 15-63 years). According to the age-adjusted International Prognostic Index (a-IPI) and the prognostic index of PTCL (PIT), 8 patients (12.5%) were in the high-risk group and 16 (26.6%) had the 2-3 PIT factors, respectively. After a median follow-up of 29.7 months, the 3-year overall survival (OS) and progression-free survival (PFS) rates were 53.0% ± 7.5% and 44.3% ± 7.0%, respectively. Univariate analysis showed that poor performance status, high lactate dehydrogenase (LDH) levels, high a-IPI score, high PIT classes, failure to achieve complete response (CR) at transplantation, and nonfrontline transplantation were associated with poor OS. Multivariate analysis showed that failure to achieve CR at transplantation (hazard ratio [HR] 2.23; 95% confidence interval [CI] 1.78-7.93) and 2-3 PIT factors (HR 3.76; 95% CI 1.02-5.42) were independent prognostic factors for OS. Failure to achieve CR at transplantation and high PIT are negative predictable factors for survival following HDT/ASCT in patients with PTCL-U.

Original languageEnglish
Pages (from-to)118-125
Number of pages8
JournalBiology of Blood and Marrow Transplantation
Volume15
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1

Fingerprint

Peripheral T-Cell Lymphoma
Stem Cell Transplantation
Transplantation
Drug Therapy
Survival
Confidence Intervals
T-Cell Lymphoma
L-Lactate Dehydrogenase
Disease-Free Survival
Multivariate Analysis
Survival Rate
T-Lymphocytes
Transplants

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

Cite this

Yang, Deok Hwan ; Kim, Won Seog ; Kim, Seok Jin ; Bae, Sung Hwa ; Kim, Sung Hyun ; Kim, In Ho ; Yoon, Sung Soo ; Mun, Yeung Chul ; Shin, Ho Jin ; Chae, Yee Soo ; Kwak, Jae Yong ; Kim, Hawk ; Kim, Min Kyoung ; Kim, Jinseok ; Won, Jong Ho ; Lee, Je Jung ; Suh, Cheol Won. / Prognostic Factors and Clinical Outcomes of High-Dose Chemotherapy followed by Autologous Stem Cell Transplantation in Patients with Peripheral T Cell Lymphoma, Unspecified : Complete Remission at Transplantation and the Prognostic Index of Peripheral T Cell Lymphoma Are the Major Factors Predictive of Outcome. In: Biology of Blood and Marrow Transplantation. 2009 ; Vol. 15, No. 1. pp. 118-125.
@article{48fe918eef0040d3899f28899c4552f4,
title = "Prognostic Factors and Clinical Outcomes of High-Dose Chemotherapy followed by Autologous Stem Cell Transplantation in Patients with Peripheral T Cell Lymphoma, Unspecified: Complete Remission at Transplantation and the Prognostic Index of Peripheral T Cell Lymphoma Are the Major Factors Predictive of Outcome",
abstract = "High-dose chemotherapy followed by autologous stem cell transplantation (HDT/ASCT) offers a rescue option for T cell lymphoma patients with poor prognosis. However, the effectiveness of HDT/ASCT in patients with various peripheral T cell subtypes, optimal transplant timing, and the prognostic factors that predict better outcomes, have not been identified. We retrospectively investigated the clinical outcomes and prognostic factors for HDT/ASCT in 64 Korean patients with peripheral T cell lymphoma, unspecified (PTCL-U) between March 1995 and February 2007. The median age at transplantation was 44 years (range: 15-63 years). According to the age-adjusted International Prognostic Index (a-IPI) and the prognostic index of PTCL (PIT), 8 patients (12.5{\%}) were in the high-risk group and 16 (26.6{\%}) had the 2-3 PIT factors, respectively. After a median follow-up of 29.7 months, the 3-year overall survival (OS) and progression-free survival (PFS) rates were 53.0{\%} ± 7.5{\%} and 44.3{\%} ± 7.0{\%}, respectively. Univariate analysis showed that poor performance status, high lactate dehydrogenase (LDH) levels, high a-IPI score, high PIT classes, failure to achieve complete response (CR) at transplantation, and nonfrontline transplantation were associated with poor OS. Multivariate analysis showed that failure to achieve CR at transplantation (hazard ratio [HR] 2.23; 95{\%} confidence interval [CI] 1.78-7.93) and 2-3 PIT factors (HR 3.76; 95{\%} CI 1.02-5.42) were independent prognostic factors for OS. Failure to achieve CR at transplantation and high PIT are negative predictable factors for survival following HDT/ASCT in patients with PTCL-U.",
author = "Yang, {Deok Hwan} and Kim, {Won Seog} and Kim, {Seok Jin} and Bae, {Sung Hwa} and Kim, {Sung Hyun} and Kim, {In Ho} and Yoon, {Sung Soo} and Mun, {Yeung Chul} and Shin, {Ho Jin} and Chae, {Yee Soo} and Kwak, {Jae Yong} and Hawk Kim and Kim, {Min Kyoung} and Jinseok Kim and Won, {Jong Ho} and Lee, {Je Jung} and Suh, {Cheol Won}",
year = "2009",
month = "1",
day = "1",
doi = "10.1016/j.bbmt.2008.11.010",
language = "English",
volume = "15",
pages = "118--125",
journal = "Biology of Blood and Marrow Transplantation",
issn = "1083-8791",
publisher = "Elsevier Inc.",
number = "1",

}

Prognostic Factors and Clinical Outcomes of High-Dose Chemotherapy followed by Autologous Stem Cell Transplantation in Patients with Peripheral T Cell Lymphoma, Unspecified : Complete Remission at Transplantation and the Prognostic Index of Peripheral T Cell Lymphoma Are the Major Factors Predictive of Outcome. / Yang, Deok Hwan; Kim, Won Seog; Kim, Seok Jin; Bae, Sung Hwa; Kim, Sung Hyun; Kim, In Ho; Yoon, Sung Soo; Mun, Yeung Chul; Shin, Ho Jin; Chae, Yee Soo; Kwak, Jae Yong; Kim, Hawk; Kim, Min Kyoung; Kim, Jinseok; Won, Jong Ho; Lee, Je Jung; Suh, Cheol Won.

In: Biology of Blood and Marrow Transplantation, Vol. 15, No. 1, 01.01.2009, p. 118-125.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostic Factors and Clinical Outcomes of High-Dose Chemotherapy followed by Autologous Stem Cell Transplantation in Patients with Peripheral T Cell Lymphoma, Unspecified

T2 - Complete Remission at Transplantation and the Prognostic Index of Peripheral T Cell Lymphoma Are the Major Factors Predictive of Outcome

AU - Yang, Deok Hwan

AU - Kim, Won Seog

AU - Kim, Seok Jin

AU - Bae, Sung Hwa

AU - Kim, Sung Hyun

AU - Kim, In Ho

AU - Yoon, Sung Soo

AU - Mun, Yeung Chul

AU - Shin, Ho Jin

AU - Chae, Yee Soo

AU - Kwak, Jae Yong

AU - Kim, Hawk

AU - Kim, Min Kyoung

AU - Kim, Jinseok

AU - Won, Jong Ho

AU - Lee, Je Jung

AU - Suh, Cheol Won

PY - 2009/1/1

Y1 - 2009/1/1

N2 - High-dose chemotherapy followed by autologous stem cell transplantation (HDT/ASCT) offers a rescue option for T cell lymphoma patients with poor prognosis. However, the effectiveness of HDT/ASCT in patients with various peripheral T cell subtypes, optimal transplant timing, and the prognostic factors that predict better outcomes, have not been identified. We retrospectively investigated the clinical outcomes and prognostic factors for HDT/ASCT in 64 Korean patients with peripheral T cell lymphoma, unspecified (PTCL-U) between March 1995 and February 2007. The median age at transplantation was 44 years (range: 15-63 years). According to the age-adjusted International Prognostic Index (a-IPI) and the prognostic index of PTCL (PIT), 8 patients (12.5%) were in the high-risk group and 16 (26.6%) had the 2-3 PIT factors, respectively. After a median follow-up of 29.7 months, the 3-year overall survival (OS) and progression-free survival (PFS) rates were 53.0% ± 7.5% and 44.3% ± 7.0%, respectively. Univariate analysis showed that poor performance status, high lactate dehydrogenase (LDH) levels, high a-IPI score, high PIT classes, failure to achieve complete response (CR) at transplantation, and nonfrontline transplantation were associated with poor OS. Multivariate analysis showed that failure to achieve CR at transplantation (hazard ratio [HR] 2.23; 95% confidence interval [CI] 1.78-7.93) and 2-3 PIT factors (HR 3.76; 95% CI 1.02-5.42) were independent prognostic factors for OS. Failure to achieve CR at transplantation and high PIT are negative predictable factors for survival following HDT/ASCT in patients with PTCL-U.

AB - High-dose chemotherapy followed by autologous stem cell transplantation (HDT/ASCT) offers a rescue option for T cell lymphoma patients with poor prognosis. However, the effectiveness of HDT/ASCT in patients with various peripheral T cell subtypes, optimal transplant timing, and the prognostic factors that predict better outcomes, have not been identified. We retrospectively investigated the clinical outcomes and prognostic factors for HDT/ASCT in 64 Korean patients with peripheral T cell lymphoma, unspecified (PTCL-U) between March 1995 and February 2007. The median age at transplantation was 44 years (range: 15-63 years). According to the age-adjusted International Prognostic Index (a-IPI) and the prognostic index of PTCL (PIT), 8 patients (12.5%) were in the high-risk group and 16 (26.6%) had the 2-3 PIT factors, respectively. After a median follow-up of 29.7 months, the 3-year overall survival (OS) and progression-free survival (PFS) rates were 53.0% ± 7.5% and 44.3% ± 7.0%, respectively. Univariate analysis showed that poor performance status, high lactate dehydrogenase (LDH) levels, high a-IPI score, high PIT classes, failure to achieve complete response (CR) at transplantation, and nonfrontline transplantation were associated with poor OS. Multivariate analysis showed that failure to achieve CR at transplantation (hazard ratio [HR] 2.23; 95% confidence interval [CI] 1.78-7.93) and 2-3 PIT factors (HR 3.76; 95% CI 1.02-5.42) were independent prognostic factors for OS. Failure to achieve CR at transplantation and high PIT are negative predictable factors for survival following HDT/ASCT in patients with PTCL-U.

UR - http://www.scopus.com/inward/record.url?scp=58149280205&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149280205&partnerID=8YFLogxK

U2 - 10.1016/j.bbmt.2008.11.010

DO - 10.1016/j.bbmt.2008.11.010

M3 - Article

VL - 15

SP - 118

EP - 125

JO - Biology of Blood and Marrow Transplantation

JF - Biology of Blood and Marrow Transplantation

SN - 1083-8791

IS - 1

ER -