Prognostic factors and renal survival rates in IgA nephropathy.

Shin-Wook Kang, K. H. Choi, J. H. Park, S. W. Lee, H. Y. Lee, D. S. Han, S. H. Seong, H. J. Jeong, I. J. Choi

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Abstract

A retrospective study of 223 patients with IgA nephropathy (IgAN) was performed to clarify the prognostic factors and the renal survival rates of the disease. One hundred twenty-two patients were followed-up for more than 6 months after their renal biopsy (mean follow-up duration: 43.0 months), and 20 of them (16.4%) had progressed to end-stage renal disease (ESRD). Using univariate analysis, 8 risk factors (2 clinical and 6 histopathological findings) for developing ESRD were identified: renal insufficiency at initial presentation (serum creatinine > or = 1.5 mg/dl); heavy proteinuria (> or = 3.5 gm/day); moderate to severe histopathologic findings such as class IV/V lesions by W.H.O. classification, mesangial hypercellularity, glomerular sclerosis, interstitial infiltration, interstitial fibrosis, and tubular atrophy. In multivariate regression analysis, class IV/V lesions and renal insufficiency at initial presentation were the independent prognostic factors of IgAN. The renal survival rates were 100% at 1 year, 97.0% at 3 years, and 78.9% at 5 years. In conclusion, it seems that about 20% of IgAN patients have a risk to progress to ESRD within 5 years, and a careful follow-up is recommended especially in patients who have either renal insufficiency at the time of presentation or severe renal pathology (class IV/V lesions).

Original languageEnglish
Pages (from-to)45-52
Number of pages8
JournalYonsei medical journal
Volume36
Issue number1
DOIs
Publication statusPublished - 1995 Jan 1

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Immunoglobulin A
Survival Rate
Chronic Kidney Failure
Renal Insufficiency
Kidney
Sclerosis
Proteinuria
Atrophy
Creatinine
Fibrosis
Multivariate Analysis
Retrospective Studies
Regression Analysis
Pathology
Biopsy
Serum

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kang, S-W., Choi, K. H., Park, J. H., Lee, S. W., Lee, H. Y., Han, D. S., ... Choi, I. J. (1995). Prognostic factors and renal survival rates in IgA nephropathy. Yonsei medical journal, 36(1), 45-52. https://doi.org/10.3349/ymj.1995.36.1.45
Kang, Shin-Wook ; Choi, K. H. ; Park, J. H. ; Lee, S. W. ; Lee, H. Y. ; Han, D. S. ; Seong, S. H. ; Jeong, H. J. ; Choi, I. J. / Prognostic factors and renal survival rates in IgA nephropathy. In: Yonsei medical journal. 1995 ; Vol. 36, No. 1. pp. 45-52.
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Kang, S-W, Choi, KH, Park, JH, Lee, SW, Lee, HY, Han, DS, Seong, SH, Jeong, HJ & Choi, IJ 1995, 'Prognostic factors and renal survival rates in IgA nephropathy.', Yonsei medical journal, vol. 36, no. 1, pp. 45-52. https://doi.org/10.3349/ymj.1995.36.1.45

Prognostic factors and renal survival rates in IgA nephropathy. / Kang, Shin-Wook; Choi, K. H.; Park, J. H.; Lee, S. W.; Lee, H. Y.; Han, D. S.; Seong, S. H.; Jeong, H. J.; Choi, I. J.

In: Yonsei medical journal, Vol. 36, No. 1, 01.01.1995, p. 45-52.

Research output: Contribution to journalArticle

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