Abstract
Purpose Metastatic biliary tract cancer (mBTC) has a dismal prognosis. In this study, an independent dataset of patients with mBTC was used to implement and validate a routine clinico-laboratory parameter-based scoring model for risk group identification. Materials and Methods From September 2006 to February 2015, 482 patients with mBTC were assigned randomly (ratio, 7:3) into investigational (n=340) and validation datasets (n=142). The continuous variables were dichotomized using a normal range or the best cutoff values determined using the Contal and O'Quigley statistical methods. Following a Cox's proportional hazard model, the scoring model was derived by summing the rounded chi-square scores for the factors identified by multivariate analysis. Results The performance status (Eastern Cooperative Oncology Group 3-4), hypoalbuminemia ( < 3.4 mg/dL), carcinoembryonic antigen (≥ 9 ng/mL), neutrophil-to-lymphocyte ratio (≥ 3.0), and carbohydrate antigen 19-9 (≥ 120 U/mL) were identified as independent prognosticators (Harrell's C index, 0.682; integrated area under the curve, 0.653). Survival was clearly correlated with the risk groups (low, intermediate, and high, 14.0, 7.3, and 2.3 months, respectively; p < 0.001). The prognosis was also discriminative in the validation data set (median survival, 16.7, 7.5, and 1.9 months, respectively; p < 0.001). Chemotherapy did not offer any survival benefits for high-risk patients. Conclusion These proposed prognostic criteria for mBTC can facilitate accurate patient risk stratification and treatment-related decision-making.
Original language | English |
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Pages (from-to) | 1127-1139 |
Number of pages | 13 |
Journal | Cancer Research and Treatment |
Volume | 49 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2017 |
Bibliographical note
Funding Information:This study was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (to H.C. Jeung, No. 1420060).
Publisher Copyright:
© 2017 by the Korean Cancer Association.
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research