Prognostic factors and treatment outcomes of parotid gland cancer

A 10-year single-center experience

Jae Won Chang, Hyun Jun Hong, Myung Jin Ban, Yoo Seob Shin, Won Shik Kim, Yoonwoo Koh, Eun Chang Choi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective To investigate the treatment outcomes of parotid gland cancer at a single center over a 10-year period and to evaluate the prognostic significance of maximum standardized uptake value. Study Design Retrospective case series with chart review. Setting Academic care center. Subjects and Methods Ninety-eight patients with primary parotid gland cancer who were surgically treated at Yonsei University Head & Neck Cancer Clinic between January 1999 and December 2008 were analyzed. Patient data were collected retrospectively from medical charts. The investigators analyzed the association of clinicopathological factors and maximum standardized uptake value on 18F-fluorodeoxyglucose positron emission tomography-computed tomography scan with disease-specific survival. Results Mean patient age was 49.7 years. Mean follow-up was 48.8 months. Thirty-three, 40, 30, and 23 patients had stage I, II, III, and IVA disease, respectively. Mucoepidermoid carcinoma was the most common histologic type (34.7%), followed by acinic cell carcinoma (27.6%). Eighteen patients (18.4%) experienced recurrences (mean recurrence gap, 20.6 months; range, 2-87 months). Five- and 10-year disease-specific survival rates were 93.6% and 81.8%, respectively. In the univariate analysis, pathologic T stage, pathologic lymph node status, resection margin, external parenchymal extension, and maximum standardized uptake value were significantly associated with disease-specific survival. Pathologic lymph node status and maximum standardized uptake value were independent prognostic factors in the multivariate analysis. Conclusion Our single-center experience with parotid gland cancer treatment is consistent with the literature. Cervical lymph node metastasis and high maximum standardized uptake value are associated with poor survival in parotid gland cancer.

Original languageEnglish
Pages (from-to)981-989
Number of pages9
JournalOtolaryngology - Head and Neck Surgery (United States)
Volume153
Issue number6
DOIs
Publication statusPublished - 2015 Dec 1

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Parotid Neoplasms
antineoplaston A10
Parotid Gland
Lymph Nodes
Survival
Acinar Cell Carcinoma
Mucoepidermoid Carcinoma
Recurrence
Fluorodeoxyglucose F18
Head and Neck Neoplasms
Multivariate Analysis
Survival Rate
Retrospective Studies
Head
Research Personnel
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Surgery
  • Otorhinolaryngology

Cite this

Chang, Jae Won ; Hong, Hyun Jun ; Ban, Myung Jin ; Shin, Yoo Seob ; Kim, Won Shik ; Koh, Yoonwoo ; Choi, Eun Chang. / Prognostic factors and treatment outcomes of parotid gland cancer : A 10-year single-center experience. In: Otolaryngology - Head and Neck Surgery (United States). 2015 ; Vol. 153, No. 6. pp. 981-989.
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title = "Prognostic factors and treatment outcomes of parotid gland cancer: A 10-year single-center experience",
abstract = "Objective To investigate the treatment outcomes of parotid gland cancer at a single center over a 10-year period and to evaluate the prognostic significance of maximum standardized uptake value. Study Design Retrospective case series with chart review. Setting Academic care center. Subjects and Methods Ninety-eight patients with primary parotid gland cancer who were surgically treated at Yonsei University Head & Neck Cancer Clinic between January 1999 and December 2008 were analyzed. Patient data were collected retrospectively from medical charts. The investigators analyzed the association of clinicopathological factors and maximum standardized uptake value on 18F-fluorodeoxyglucose positron emission tomography-computed tomography scan with disease-specific survival. Results Mean patient age was 49.7 years. Mean follow-up was 48.8 months. Thirty-three, 40, 30, and 23 patients had stage I, II, III, and IVA disease, respectively. Mucoepidermoid carcinoma was the most common histologic type (34.7{\%}), followed by acinic cell carcinoma (27.6{\%}). Eighteen patients (18.4{\%}) experienced recurrences (mean recurrence gap, 20.6 months; range, 2-87 months). Five- and 10-year disease-specific survival rates were 93.6{\%} and 81.8{\%}, respectively. In the univariate analysis, pathologic T stage, pathologic lymph node status, resection margin, external parenchymal extension, and maximum standardized uptake value were significantly associated with disease-specific survival. Pathologic lymph node status and maximum standardized uptake value were independent prognostic factors in the multivariate analysis. Conclusion Our single-center experience with parotid gland cancer treatment is consistent with the literature. Cervical lymph node metastasis and high maximum standardized uptake value are associated with poor survival in parotid gland cancer.",
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Prognostic factors and treatment outcomes of parotid gland cancer : A 10-year single-center experience. / Chang, Jae Won; Hong, Hyun Jun; Ban, Myung Jin; Shin, Yoo Seob; Kim, Won Shik; Koh, Yoonwoo; Choi, Eun Chang.

In: Otolaryngology - Head and Neck Surgery (United States), Vol. 153, No. 6, 01.12.2015, p. 981-989.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostic factors and treatment outcomes of parotid gland cancer

T2 - A 10-year single-center experience

AU - Chang, Jae Won

AU - Hong, Hyun Jun

AU - Ban, Myung Jin

AU - Shin, Yoo Seob

AU - Kim, Won Shik

AU - Koh, Yoonwoo

AU - Choi, Eun Chang

PY - 2015/12/1

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N2 - Objective To investigate the treatment outcomes of parotid gland cancer at a single center over a 10-year period and to evaluate the prognostic significance of maximum standardized uptake value. Study Design Retrospective case series with chart review. Setting Academic care center. Subjects and Methods Ninety-eight patients with primary parotid gland cancer who were surgically treated at Yonsei University Head & Neck Cancer Clinic between January 1999 and December 2008 were analyzed. Patient data were collected retrospectively from medical charts. The investigators analyzed the association of clinicopathological factors and maximum standardized uptake value on 18F-fluorodeoxyglucose positron emission tomography-computed tomography scan with disease-specific survival. Results Mean patient age was 49.7 years. Mean follow-up was 48.8 months. Thirty-three, 40, 30, and 23 patients had stage I, II, III, and IVA disease, respectively. Mucoepidermoid carcinoma was the most common histologic type (34.7%), followed by acinic cell carcinoma (27.6%). Eighteen patients (18.4%) experienced recurrences (mean recurrence gap, 20.6 months; range, 2-87 months). Five- and 10-year disease-specific survival rates were 93.6% and 81.8%, respectively. In the univariate analysis, pathologic T stage, pathologic lymph node status, resection margin, external parenchymal extension, and maximum standardized uptake value were significantly associated with disease-specific survival. Pathologic lymph node status and maximum standardized uptake value were independent prognostic factors in the multivariate analysis. Conclusion Our single-center experience with parotid gland cancer treatment is consistent with the literature. Cervical lymph node metastasis and high maximum standardized uptake value are associated with poor survival in parotid gland cancer.

AB - Objective To investigate the treatment outcomes of parotid gland cancer at a single center over a 10-year period and to evaluate the prognostic significance of maximum standardized uptake value. Study Design Retrospective case series with chart review. Setting Academic care center. Subjects and Methods Ninety-eight patients with primary parotid gland cancer who were surgically treated at Yonsei University Head & Neck Cancer Clinic between January 1999 and December 2008 were analyzed. Patient data were collected retrospectively from medical charts. The investigators analyzed the association of clinicopathological factors and maximum standardized uptake value on 18F-fluorodeoxyglucose positron emission tomography-computed tomography scan with disease-specific survival. Results Mean patient age was 49.7 years. Mean follow-up was 48.8 months. Thirty-three, 40, 30, and 23 patients had stage I, II, III, and IVA disease, respectively. Mucoepidermoid carcinoma was the most common histologic type (34.7%), followed by acinic cell carcinoma (27.6%). Eighteen patients (18.4%) experienced recurrences (mean recurrence gap, 20.6 months; range, 2-87 months). Five- and 10-year disease-specific survival rates were 93.6% and 81.8%, respectively. In the univariate analysis, pathologic T stage, pathologic lymph node status, resection margin, external parenchymal extension, and maximum standardized uptake value were significantly associated with disease-specific survival. Pathologic lymph node status and maximum standardized uptake value were independent prognostic factors in the multivariate analysis. Conclusion Our single-center experience with parotid gland cancer treatment is consistent with the literature. Cervical lymph node metastasis and high maximum standardized uptake value are associated with poor survival in parotid gland cancer.

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