Introduction: This retrospective study examined the potential prognostic factors on the outcome after endodontic microsurgery and compared the predictors of isolated endodontic lesion with those of both isolated endodontic lesions and endodontic-periodontal lesions. Methods: The data were collected from patients with a history of endodontic microsurgery performed between August 2004 and December 2008 and at least 1 year before being evaluated. Surgical procedures were performed by the endodontic faculty and residents. After surgery, an operation record form was made with the preoperative, intraoperative, and postoperative factors from the clinical and radiographic measures. For statistical analysis of the predisposing factors, the dependent variable was the dichotomous outcome (ie, success vs failure). Results: Of 907 cases, 491 were retained at follow-up. At the 0.05 level of significance, age, sex (female), tooth position (anterior), root-filling length (adequate), lesion type (endodontic lesion), root-end filling material (mineral trioxide aggregate and Super EBA; Harry J. Bosworth, Skokie, IL), and restoration at follow-up appeared to have a positive effect on the outcome. On the other hand, with an isolated endodontic lesion, the tooth position (anterior), root-filling length (adequate), and restoration at follow-up were significant factors at the 95% confidence level. Conclusions: Under the control of the significant variables in logistic regression, the potential prognostic factors on the outcome were sex, tooth position, lesion type, and root-end filling material. On the other hand, the tooth position was a pure predictor of an endodontic lesion affecting the clinical outcome.
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