Abstract
Background/Aim: The analysis of prognostic factors is important to identify determinants of disease-free survival (DFS) and overall survival (OS) in resected non-small-cell lung cancer (NSCLC). Patients and Methods: We examined baseline characteristics associated with DFS and OS among 757 patients with resected, histologically proven, MAGE-A3-positive Stage IB-IIIA NSCLC assigned to placebo in the MAGRIT study (NCT00480025). We explored characteristics of NSCLC that could predict DFS and OS using Cox regression models. Results: The multivariate analysis showed that lower nodal stage, the presence of squamous cell carcinoma (SCC), a broader surgical resection in patients with SCC, and being female with non-SCC were significantly associated with longer DFS. Lower nodal stage and smaller tumor size were significantly associated with an improved OS. Compared to Other International, enrollment in East Asia was associated with an improved OS in patients with non-SCC. Conclusion: This is the first prognostic factor analysis in NSCLC performed on data from a large prospective study. These results confirm retrospective studies and add that histopathology subtype is a strong determinant of DFS in resected MAGE-A3-positive NSCLC.
| Original language | English |
|---|---|
| Pages (from-to) | 1403-1409 |
| Number of pages | 7 |
| Journal | Anticancer research |
| Volume | 39 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2019 Mar 1 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
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Prognostic factors in early-stage NSCLC : Analysis of the placebo group in the MAGRIT study. / Cho, Byoung Chul; De Pas, Tommaso; Kalofonos, Haralabos; Wang, Qun; Ramlau, Rodryg; Cheng, Ying; Vitiello, Fabiana; Laisaar, Tanel; Vallières, Eric; Kubisa, Bartosz; Orlov, Sergey; Park, Keunchil; Debruyne, Channa; Vansteenkiste, Johan.
In: Anticancer research, Vol. 39, No. 3, 01.03.2019, p. 1403-1409.Research output: Contribution to journal › Article
TY - JOUR
T1 - Prognostic factors in early-stage NSCLC
T2 - Analysis of the placebo group in the MAGRIT study
AU - Cho, Byoung Chul
AU - De Pas, Tommaso
AU - Kalofonos, Haralabos
AU - Wang, Qun
AU - Ramlau, Rodryg
AU - Cheng, Ying
AU - Vitiello, Fabiana
AU - Laisaar, Tanel
AU - Vallières, Eric
AU - Kubisa, Bartosz
AU - Orlov, Sergey
AU - Park, Keunchil
AU - Debruyne, Channa
AU - Vansteenkiste, Johan
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Background/Aim: The analysis of prognostic factors is important to identify determinants of disease-free survival (DFS) and overall survival (OS) in resected non-small-cell lung cancer (NSCLC). Patients and Methods: We examined baseline characteristics associated with DFS and OS among 757 patients with resected, histologically proven, MAGE-A3-positive Stage IB-IIIA NSCLC assigned to placebo in the MAGRIT study (NCT00480025). We explored characteristics of NSCLC that could predict DFS and OS using Cox regression models. Results: The multivariate analysis showed that lower nodal stage, the presence of squamous cell carcinoma (SCC), a broader surgical resection in patients with SCC, and being female with non-SCC were significantly associated with longer DFS. Lower nodal stage and smaller tumor size were significantly associated with an improved OS. Compared to Other International, enrollment in East Asia was associated with an improved OS in patients with non-SCC. Conclusion: This is the first prognostic factor analysis in NSCLC performed on data from a large prospective study. These results confirm retrospective studies and add that histopathology subtype is a strong determinant of DFS in resected MAGE-A3-positive NSCLC.
AB - Background/Aim: The analysis of prognostic factors is important to identify determinants of disease-free survival (DFS) and overall survival (OS) in resected non-small-cell lung cancer (NSCLC). Patients and Methods: We examined baseline characteristics associated with DFS and OS among 757 patients with resected, histologically proven, MAGE-A3-positive Stage IB-IIIA NSCLC assigned to placebo in the MAGRIT study (NCT00480025). We explored characteristics of NSCLC that could predict DFS and OS using Cox regression models. Results: The multivariate analysis showed that lower nodal stage, the presence of squamous cell carcinoma (SCC), a broader surgical resection in patients with SCC, and being female with non-SCC were significantly associated with longer DFS. Lower nodal stage and smaller tumor size were significantly associated with an improved OS. Compared to Other International, enrollment in East Asia was associated with an improved OS in patients with non-SCC. Conclusion: This is the first prognostic factor analysis in NSCLC performed on data from a large prospective study. These results confirm retrospective studies and add that histopathology subtype is a strong determinant of DFS in resected MAGE-A3-positive NSCLC.
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U2 - 10.21873/anticanres.13255
DO - 10.21873/anticanres.13255
M3 - Article
C2 - 30842175
AN - SCOPUS:85062644717
VL - 39
SP - 1403
EP - 1409
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 3
ER -