The aim of this study was to evaluate the longevity of teeth with single-visit endodontic and restorative treatment under general anaesthesia (GA) for special needs patients and to investigate factors associated with survival and success. Data were collected from 381 teeth in 203 patients [mean (s.d.) age = 27.0 (14.1)]. All endodontic and restorative procedures were performed during a single GA session except for cementation of crowns in the cases requiring crown restoration (38%). A total of 267 teeth (70.6%) were followed-up for 6-81 months [mean (s.d.): 32.7 (20.0)]. Patients and teeth with and without follow-up were compared. Kaplan-Meier analysis with generalised Wilcoxon test was used to compare the mean survival and success period. Cox proportion hazard regression model was applied for multivariate analysis. At the end of the observation period, 10 teeth had a crown fracture (5-year survival rate = 89.8%), and an additional 10 teeth had primary or secondary caries (5-year success rate = 86.4%). Risk factors associated with survival were age (>40), non-parental caregiver, cooperation level and periodontal disease. A soft diet was an additional risk factor against the success of teeth. Single-visit endodontic and restorative treatment under GA showed favourable outcomes, suggesting a promising treatment option for special needs patients. Patient- and dental-specific circumstances need to be carefully considered to enhance the longevity of reconstructed teeth.