Abstract
Background The aim of this study is to estimate prognostic factors predicting survival in patients with incurable stage IV colorectal cancer (CRC), who underwent palliative primary tumor resection (PTR) with chemotherapy. Materials and methods We retrospectively performed an analysis using clinicopathological parameters of 103 patients with incurable stage IV CRC, who underwent palliative PTR with chemotherapy between 2006 and 2010. Prognostic factors associated with overall survival (OS) were evaluated by univariate and multivariate analyses. Results The median follow-up time was 17.5 months (range 2.4–60.5) for the total cohort (n = 103). There were five independent factors related to OS in univariate analysis (body mass index, tumor differentiation, pT, pN stage and local clearance of the primary tumor). A multivariate analysis revealed that pT, pN and local clearance of the primary tumor were prognostic factors related to OS. Median survival months (95% CI) were pT1, 2, 3: 21.5 (16.23–26.77) months vs. pT4: 13.73 (9.94–17.53) months, pN-: 29.7 (22.55–35.99) months vs. pN+: 17.1 (15.0–19.41) months and R0: 18.57 (16.65–20.48) months vs. R1, 2: 12.43 (9.95–14.91) months. Conclusion Locally advanced primary tumor (high pT stage, positive regional lymph node, and local residual primary tumor) was associated with poorer OS in incurable stage IV CRC patients, who underwent palliative PTR with chemotherapy. The PTR appears to result in better OS in patients with a primary tumor that is not locally advanced.
Original language | English |
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Pages (from-to) | 10-15 |
Number of pages | 6 |
Journal | International Journal of Surgery |
Volume | 49 |
DOIs | |
Publication status | Published - 2018 Jan |
Bibliographical note
Funding Information:This study was supported by the Korean National Cancer Control Planning Board Study 2013 (no. 1320260 ), which is funded by the Ministry of Health and Welfare and managed by the National Cancer Center .
Publisher Copyright:
© 2017 IJS Publishing Group Ltd
All Science Journal Classification (ASJC) codes
- Surgery