Abstract
Background The aim of this study is to estimate prognostic factors predicting survival in patients with incurable stage IV colorectal cancer (CRC), who underwent palliative primary tumor resection (PTR) with chemotherapy. Materials and methods We retrospectively performed an analysis using clinicopathological parameters of 103 patients with incurable stage IV CRC, who underwent palliative PTR with chemotherapy between 2006 and 2010. Prognostic factors associated with overall survival (OS) were evaluated by univariate and multivariate analyses. Results The median follow-up time was 17.5 months (range 2.4–60.5) for the total cohort (n = 103). There were five independent factors related to OS in univariate analysis (body mass index, tumor differentiation, pT, pN stage and local clearance of the primary tumor). A multivariate analysis revealed that pT, pN and local clearance of the primary tumor were prognostic factors related to OS. Median survival months (95% CI) were pT1, 2, 3: 21.5 (16.23–26.77) months vs. pT4: 13.73 (9.94–17.53) months, pN-: 29.7 (22.55–35.99) months vs. pN+: 17.1 (15.0–19.41) months and R0: 18.57 (16.65–20.48) months vs. R1, 2: 12.43 (9.95–14.91) months. Conclusion Locally advanced primary tumor (high pT stage, positive regional lymph node, and local residual primary tumor) was associated with poorer OS in incurable stage IV CRC patients, who underwent palliative PTR with chemotherapy. The PTR appears to result in better OS in patients with a primary tumor that is not locally advanced.
| Original language | English |
|---|---|
| Pages (from-to) | 10-15 |
| Number of pages | 6 |
| Journal | International Journal of Surgery |
| Volume | 49 |
| DOIs | |
| Publication status | Published - 2018 Jan |
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All Science Journal Classification (ASJC) codes
- Surgery
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Prognostic factors predicting survival in incurable stage IV colorectal cancer patients who underwent palliative primary tumor resection. Retrospective cohort study. / Kim, Min Sung; Park, Eun Jung; Kang, Jeonghyun; Min, Byung Soh; Lee, Kang Young; Kim, Nam Kyu; Baik, Seung Hyuk.
In: International Journal of Surgery, Vol. 49, 01.2018, p. 10-15.Research output: Contribution to journal › Article
TY - JOUR
T1 - Prognostic factors predicting survival in incurable stage IV colorectal cancer patients who underwent palliative primary tumor resection. Retrospective cohort study
AU - Kim, Min Sung
AU - Park, Eun Jung
AU - Kang, Jeonghyun
AU - Min, Byung Soh
AU - Lee, Kang Young
AU - Kim, Nam Kyu
AU - Baik, Seung Hyuk
PY - 2018/1
Y1 - 2018/1
N2 - Background The aim of this study is to estimate prognostic factors predicting survival in patients with incurable stage IV colorectal cancer (CRC), who underwent palliative primary tumor resection (PTR) with chemotherapy. Materials and methods We retrospectively performed an analysis using clinicopathological parameters of 103 patients with incurable stage IV CRC, who underwent palliative PTR with chemotherapy between 2006 and 2010. Prognostic factors associated with overall survival (OS) were evaluated by univariate and multivariate analyses. Results The median follow-up time was 17.5 months (range 2.4–60.5) for the total cohort (n = 103). There were five independent factors related to OS in univariate analysis (body mass index, tumor differentiation, pT, pN stage and local clearance of the primary tumor). A multivariate analysis revealed that pT, pN and local clearance of the primary tumor were prognostic factors related to OS. Median survival months (95% CI) were pT1, 2, 3: 21.5 (16.23–26.77) months vs. pT4: 13.73 (9.94–17.53) months, pN-: 29.7 (22.55–35.99) months vs. pN+: 17.1 (15.0–19.41) months and R0: 18.57 (16.65–20.48) months vs. R1, 2: 12.43 (9.95–14.91) months. Conclusion Locally advanced primary tumor (high pT stage, positive regional lymph node, and local residual primary tumor) was associated with poorer OS in incurable stage IV CRC patients, who underwent palliative PTR with chemotherapy. The PTR appears to result in better OS in patients with a primary tumor that is not locally advanced.
AB - Background The aim of this study is to estimate prognostic factors predicting survival in patients with incurable stage IV colorectal cancer (CRC), who underwent palliative primary tumor resection (PTR) with chemotherapy. Materials and methods We retrospectively performed an analysis using clinicopathological parameters of 103 patients with incurable stage IV CRC, who underwent palliative PTR with chemotherapy between 2006 and 2010. Prognostic factors associated with overall survival (OS) were evaluated by univariate and multivariate analyses. Results The median follow-up time was 17.5 months (range 2.4–60.5) for the total cohort (n = 103). There were five independent factors related to OS in univariate analysis (body mass index, tumor differentiation, pT, pN stage and local clearance of the primary tumor). A multivariate analysis revealed that pT, pN and local clearance of the primary tumor were prognostic factors related to OS. Median survival months (95% CI) were pT1, 2, 3: 21.5 (16.23–26.77) months vs. pT4: 13.73 (9.94–17.53) months, pN-: 29.7 (22.55–35.99) months vs. pN+: 17.1 (15.0–19.41) months and R0: 18.57 (16.65–20.48) months vs. R1, 2: 12.43 (9.95–14.91) months. Conclusion Locally advanced primary tumor (high pT stage, positive regional lymph node, and local residual primary tumor) was associated with poorer OS in incurable stage IV CRC patients, who underwent palliative PTR with chemotherapy. The PTR appears to result in better OS in patients with a primary tumor that is not locally advanced.
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U2 - 10.1016/j.ijsu.2017.11.038
DO - 10.1016/j.ijsu.2017.11.038
M3 - Article
C2 - 29198632
AN - SCOPUS:85037627921
VL - 49
SP - 10
EP - 15
JO - International Journal of Surgery
JF - International Journal of Surgery
SN - 1743-9191
ER -