Prognostic factors predicting survival in incurable stage IV colorectal cancer patients who underwent palliative primary tumor resection. Retrospective cohort study

Min Sung Kim, Eun Jung Park, Jeonghyun Kang, Byung Soh Min, Kang Young Lee, Namkyu Kim, Seung Hyuk Baik

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Abstract

Background The aim of this study is to estimate prognostic factors predicting survival in patients with incurable stage IV colorectal cancer (CRC), who underwent palliative primary tumor resection (PTR) with chemotherapy. Materials and methods We retrospectively performed an analysis using clinicopathological parameters of 103 patients with incurable stage IV CRC, who underwent palliative PTR with chemotherapy between 2006 and 2010. Prognostic factors associated with overall survival (OS) were evaluated by univariate and multivariate analyses. Results The median follow-up time was 17.5 months (range 2.4–60.5) for the total cohort (n = 103). There were five independent factors related to OS in univariate analysis (body mass index, tumor differentiation, pT, pN stage and local clearance of the primary tumor). A multivariate analysis revealed that pT, pN and local clearance of the primary tumor were prognostic factors related to OS. Median survival months (95% CI) were pT1, 2, 3: 21.5 (16.23–26.77) months vs. pT4: 13.73 (9.94–17.53) months, pN-: 29.7 (22.55–35.99) months vs. pN+: 17.1 (15.0–19.41) months and R0: 18.57 (16.65–20.48) months vs. R1, 2: 12.43 (9.95–14.91) months. Conclusion Locally advanced primary tumor (high pT stage, positive regional lymph node, and local residual primary tumor) was associated with poorer OS in incurable stage IV CRC patients, who underwent palliative PTR with chemotherapy. The PTR appears to result in better OS in patients with a primary tumor that is not locally advanced.

Original languageEnglish
Pages (from-to)10-15
Number of pages6
JournalInternational Journal of Surgery
Volume49
DOIs
Publication statusPublished - 2018 Jan 1

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Colorectal Neoplasms
Cohort Studies
Retrospective Studies
Survival
Neoplasms
Drug Therapy
Multivariate Analysis
Residual Neoplasm
Body Mass Index
Lymph Nodes

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Kim, Min Sung ; Park, Eun Jung ; Kang, Jeonghyun ; Min, Byung Soh ; Lee, Kang Young ; Kim, Namkyu ; Baik, Seung Hyuk. / Prognostic factors predicting survival in incurable stage IV colorectal cancer patients who underwent palliative primary tumor resection. Retrospective cohort study. In: International Journal of Surgery. 2018 ; Vol. 49. pp. 10-15.
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title = "Prognostic factors predicting survival in incurable stage IV colorectal cancer patients who underwent palliative primary tumor resection. Retrospective cohort study",
abstract = "Background The aim of this study is to estimate prognostic factors predicting survival in patients with incurable stage IV colorectal cancer (CRC), who underwent palliative primary tumor resection (PTR) with chemotherapy. Materials and methods We retrospectively performed an analysis using clinicopathological parameters of 103 patients with incurable stage IV CRC, who underwent palliative PTR with chemotherapy between 2006 and 2010. Prognostic factors associated with overall survival (OS) were evaluated by univariate and multivariate analyses. Results The median follow-up time was 17.5 months (range 2.4–60.5) for the total cohort (n = 103). There were five independent factors related to OS in univariate analysis (body mass index, tumor differentiation, pT, pN stage and local clearance of the primary tumor). A multivariate analysis revealed that pT, pN and local clearance of the primary tumor were prognostic factors related to OS. Median survival months (95{\%} CI) were pT1, 2, 3: 21.5 (16.23–26.77) months vs. pT4: 13.73 (9.94–17.53) months, pN-: 29.7 (22.55–35.99) months vs. pN+: 17.1 (15.0–19.41) months and R0: 18.57 (16.65–20.48) months vs. R1, 2: 12.43 (9.95–14.91) months. Conclusion Locally advanced primary tumor (high pT stage, positive regional lymph node, and local residual primary tumor) was associated with poorer OS in incurable stage IV CRC patients, who underwent palliative PTR with chemotherapy. The PTR appears to result in better OS in patients with a primary tumor that is not locally advanced.",
author = "Kim, {Min Sung} and Park, {Eun Jung} and Jeonghyun Kang and Min, {Byung Soh} and Lee, {Kang Young} and Namkyu Kim and Baik, {Seung Hyuk}",
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Prognostic factors predicting survival in incurable stage IV colorectal cancer patients who underwent palliative primary tumor resection. Retrospective cohort study. / Kim, Min Sung; Park, Eun Jung; Kang, Jeonghyun; Min, Byung Soh; Lee, Kang Young; Kim, Namkyu; Baik, Seung Hyuk.

In: International Journal of Surgery, Vol. 49, 01.01.2018, p. 10-15.

Research output: Contribution to journalArticle

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AU - Lee, Kang Young

AU - Kim, Namkyu

AU - Baik, Seung Hyuk

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N2 - Background The aim of this study is to estimate prognostic factors predicting survival in patients with incurable stage IV colorectal cancer (CRC), who underwent palliative primary tumor resection (PTR) with chemotherapy. Materials and methods We retrospectively performed an analysis using clinicopathological parameters of 103 patients with incurable stage IV CRC, who underwent palliative PTR with chemotherapy between 2006 and 2010. Prognostic factors associated with overall survival (OS) were evaluated by univariate and multivariate analyses. Results The median follow-up time was 17.5 months (range 2.4–60.5) for the total cohort (n = 103). There were five independent factors related to OS in univariate analysis (body mass index, tumor differentiation, pT, pN stage and local clearance of the primary tumor). A multivariate analysis revealed that pT, pN and local clearance of the primary tumor were prognostic factors related to OS. Median survival months (95% CI) were pT1, 2, 3: 21.5 (16.23–26.77) months vs. pT4: 13.73 (9.94–17.53) months, pN-: 29.7 (22.55–35.99) months vs. pN+: 17.1 (15.0–19.41) months and R0: 18.57 (16.65–20.48) months vs. R1, 2: 12.43 (9.95–14.91) months. Conclusion Locally advanced primary tumor (high pT stage, positive regional lymph node, and local residual primary tumor) was associated with poorer OS in incurable stage IV CRC patients, who underwent palliative PTR with chemotherapy. The PTR appears to result in better OS in patients with a primary tumor that is not locally advanced.

AB - Background The aim of this study is to estimate prognostic factors predicting survival in patients with incurable stage IV colorectal cancer (CRC), who underwent palliative primary tumor resection (PTR) with chemotherapy. Materials and methods We retrospectively performed an analysis using clinicopathological parameters of 103 patients with incurable stage IV CRC, who underwent palliative PTR with chemotherapy between 2006 and 2010. Prognostic factors associated with overall survival (OS) were evaluated by univariate and multivariate analyses. Results The median follow-up time was 17.5 months (range 2.4–60.5) for the total cohort (n = 103). There were five independent factors related to OS in univariate analysis (body mass index, tumor differentiation, pT, pN stage and local clearance of the primary tumor). A multivariate analysis revealed that pT, pN and local clearance of the primary tumor were prognostic factors related to OS. Median survival months (95% CI) were pT1, 2, 3: 21.5 (16.23–26.77) months vs. pT4: 13.73 (9.94–17.53) months, pN-: 29.7 (22.55–35.99) months vs. pN+: 17.1 (15.0–19.41) months and R0: 18.57 (16.65–20.48) months vs. R1, 2: 12.43 (9.95–14.91) months. Conclusion Locally advanced primary tumor (high pT stage, positive regional lymph node, and local residual primary tumor) was associated with poorer OS in incurable stage IV CRC patients, who underwent palliative PTR with chemotherapy. The PTR appears to result in better OS in patients with a primary tumor that is not locally advanced.

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