Prognostic factors predicting survival in incurable stage IV colorectal cancer patients who underwent palliative primary tumor resection. Retrospective cohort study

Min Sung Kim, Eun Jung Park, Jeonghyun Kang, Byung Soh Min, Kang Young Lee, Nam Kyu Kim, Seung Hyuk Baik

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3 Citations (Scopus)

Abstract

Background The aim of this study is to estimate prognostic factors predicting survival in patients with incurable stage IV colorectal cancer (CRC), who underwent palliative primary tumor resection (PTR) with chemotherapy. Materials and methods We retrospectively performed an analysis using clinicopathological parameters of 103 patients with incurable stage IV CRC, who underwent palliative PTR with chemotherapy between 2006 and 2010. Prognostic factors associated with overall survival (OS) were evaluated by univariate and multivariate analyses. Results The median follow-up time was 17.5 months (range 2.4–60.5) for the total cohort (n = 103). There were five independent factors related to OS in univariate analysis (body mass index, tumor differentiation, pT, pN stage and local clearance of the primary tumor). A multivariate analysis revealed that pT, pN and local clearance of the primary tumor were prognostic factors related to OS. Median survival months (95% CI) were pT1, 2, 3: 21.5 (16.23–26.77) months vs. pT4: 13.73 (9.94–17.53) months, pN-: 29.7 (22.55–35.99) months vs. pN+: 17.1 (15.0–19.41) months and R0: 18.57 (16.65–20.48) months vs. R1, 2: 12.43 (9.95–14.91) months. Conclusion Locally advanced primary tumor (high pT stage, positive regional lymph node, and local residual primary tumor) was associated with poorer OS in incurable stage IV CRC patients, who underwent palliative PTR with chemotherapy. The PTR appears to result in better OS in patients with a primary tumor that is not locally advanced.

Original languageEnglish
Pages (from-to)10-15
Number of pages6
JournalInternational Journal of Surgery
Volume49
DOIs
Publication statusPublished - 2018 Jan

Bibliographical note

Funding Information:
This study was supported by the Korean National Cancer Control Planning Board Study 2013 (no. 1320260 ), which is funded by the Ministry of Health and Welfare and managed by the National Cancer Center .

All Science Journal Classification (ASJC) codes

  • Surgery

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