Prognostic group stratification and nomogram for predicting overall survival in patients who received radiotherapy for abdominal lymph node metastasis from hepatocellular carcinoma: A multi-institutional retrospective study (KROG 15-02)

Youngkyong Kim, Hee Chul Park, Sang Min Yoon, Tae Hyun Kim, Jieun Lee, Jinhyun Choi, Jeong Il Yu, Jin Hong Park, Jong Hoon Kim, Joong Won Park, Jinsil Seong

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Objective: To develop a prognostic model for overall survival (OS) in hepatocellular carcinoma (HCC) patients receiving radiotherapy (RT) to metastatic abdominal lymph nodes (LNs). Materials and Methods: Two hundred twenty-eight patients treated with RT to metastatic abdominal LNs were retrospectively reviewed. Results: Median OS in all patients was 11.1 months. LN responders had significantly higher median OS than non-responders (14.2 months vs. 7.5 months, p < 0.05). On multivariate analysis, Child-Pugh classification, status of intrahepatic tumor, presence of distant metastasis, number and location of metastatic LNs, serum level of alpha fetoprotein (AFP), and the LN response to RT were significant prognostic factors for OS (p < 0.05 each). Based on the results of multivariate analysis, prognostic group stratification according to the number of pre-treatment risk factors was a significant predictor of OS, and median OS in patients with ≥ 4, 3, 2, 1, and 0 risk factors were 2.9, 5.5, 10.3, 13.6, and 27.8 months, respectively (p < 0.05). A nomogram was formulated by integrating the different prognostic contribution of each factor, and it showed good accuracy for predicting 2-year OS with a concordance index of 0.72. Conclusion: Prognostic group stratification and nomogram could be useful prognostic and therapeutic indicators in selecting treatment strategies.

Original languageEnglish
Pages (from-to)94450-94461
Number of pages12
JournalOncotarget
Volume8
Issue number55
DOIs
Publication statusPublished - 2017 Nov 1

Bibliographical note

Funding Information:
The present affiliation of Y. Kim is the Department of Radiation Oncology, Kyung Hee University Hospital, Seoul, Korea. This study was supported by National Cancer Center Grant (NCC 1710060 and 1710030).

Publisher Copyright:
© Kim et al.

All Science Journal Classification (ASJC) codes

  • Oncology

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