Prognostic impact of preexisting hypertension and high systolic blood pressure at admission in patients hospitalized for systolic heart failure

Ji Hyun Lee, Junwon Lee, Youngjin Youn, Minsoo Ahn, Sung Gyun Ahn, Jang Young Kim, Seunghwan Lee, Junghan Yoon, Jaewon Oh, seokmin kang, Eun Seok Jeon, Dong Ju Choi, Kyu Hyung Ryu, Byungsu Yoo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Higher systolic blood pressure (SBP) has been reported to be associated with a better prognosis in heart failure (HF) patients. This study aimed to investigate the prognostic impact of hypertension in patients hospitalized with systolic HF. Methods: Pooled analysis of data from three Korean observational studies was performed. Patients ≥18 years hospitalized with systolic HF (ejection fraction ≤45%) (n = 3538) were compared for the incidence of 1-year all-cause mortality according to the presence of preexisting hypertension and SBP quartiles on admission. Results: Patients with hypertension (prevalence, 51.6%) presented more often with diabetes (43.9% vs. 23.0%, p < 0.001) and chronic kidney disease (14.1% vs. 5.7%, p < 0.001). During the 1-year follow-up, patients with hypertension showed similar cumulative incidences of all-cause mortality as those without hypertension (8.3% vs. 8.4%, p = 0.900). Conversely, patients with higher SBP on admission had a lower incidence of all-cause death (quartile 4 vs. 1: 6.7% vs. 11.3%, p for trend = 0.004). In the multivariate analysis, an increase in SBP of 10 mmHg was associated with an 8.5% risk reduction of all-cause death (hazard ratio: 0.915, 95% confidence interval: 0.853-0.981, p = 0.013). Conclusions: Higher SBP on admission was independently associated with a lower risk of 1-year all-cause mortality in systolic HF.

Original languageEnglish
Pages (from-to)418-423
Number of pages6
JournalJournal of Cardiology
Volume67
Issue number5
DOIs
Publication statusPublished - 2016 May 1

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Systolic Heart Failure
Patient Admission
Blood Pressure
Hypertension
Mortality
Cause of Death
Incidence
Risk Reduction Behavior
Chronic Renal Insufficiency
Observational Studies
Multivariate Analysis
Heart Failure
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{a3c977687a464e75b09a2d0a1fab6a96,
title = "Prognostic impact of preexisting hypertension and high systolic blood pressure at admission in patients hospitalized for systolic heart failure",
abstract = "Background: Higher systolic blood pressure (SBP) has been reported to be associated with a better prognosis in heart failure (HF) patients. This study aimed to investigate the prognostic impact of hypertension in patients hospitalized with systolic HF. Methods: Pooled analysis of data from three Korean observational studies was performed. Patients ≥18 years hospitalized with systolic HF (ejection fraction ≤45{\%}) (n = 3538) were compared for the incidence of 1-year all-cause mortality according to the presence of preexisting hypertension and SBP quartiles on admission. Results: Patients with hypertension (prevalence, 51.6{\%}) presented more often with diabetes (43.9{\%} vs. 23.0{\%}, p < 0.001) and chronic kidney disease (14.1{\%} vs. 5.7{\%}, p < 0.001). During the 1-year follow-up, patients with hypertension showed similar cumulative incidences of all-cause mortality as those without hypertension (8.3{\%} vs. 8.4{\%}, p = 0.900). Conversely, patients with higher SBP on admission had a lower incidence of all-cause death (quartile 4 vs. 1: 6.7{\%} vs. 11.3{\%}, p for trend = 0.004). In the multivariate analysis, an increase in SBP of 10 mmHg was associated with an 8.5{\%} risk reduction of all-cause death (hazard ratio: 0.915, 95{\%} confidence interval: 0.853-0.981, p = 0.013). Conclusions: Higher SBP on admission was independently associated with a lower risk of 1-year all-cause mortality in systolic HF.",
author = "Lee, {Ji Hyun} and Junwon Lee and Youngjin Youn and Minsoo Ahn and Ahn, {Sung Gyun} and Kim, {Jang Young} and Seunghwan Lee and Junghan Yoon and Jaewon Oh and seokmin kang and Jeon, {Eun Seok} and Choi, {Dong Ju} and Ryu, {Kyu Hyung} and Byungsu Yoo",
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language = "English",
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issn = "0914-5087",
publisher = "Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai)",
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Prognostic impact of preexisting hypertension and high systolic blood pressure at admission in patients hospitalized for systolic heart failure. / Lee, Ji Hyun; Lee, Junwon; Youn, Youngjin; Ahn, Minsoo; Ahn, Sung Gyun; Kim, Jang Young; Lee, Seunghwan; Yoon, Junghan; Oh, Jaewon; kang, seokmin; Jeon, Eun Seok; Choi, Dong Ju; Ryu, Kyu Hyung; Yoo, Byungsu.

In: Journal of Cardiology, Vol. 67, No. 5, 01.05.2016, p. 418-423.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostic impact of preexisting hypertension and high systolic blood pressure at admission in patients hospitalized for systolic heart failure

AU - Lee, Ji Hyun

AU - Lee, Junwon

AU - Youn, Youngjin

AU - Ahn, Minsoo

AU - Ahn, Sung Gyun

AU - Kim, Jang Young

AU - Lee, Seunghwan

AU - Yoon, Junghan

AU - Oh, Jaewon

AU - kang, seokmin

AU - Jeon, Eun Seok

AU - Choi, Dong Ju

AU - Ryu, Kyu Hyung

AU - Yoo, Byungsu

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Background: Higher systolic blood pressure (SBP) has been reported to be associated with a better prognosis in heart failure (HF) patients. This study aimed to investigate the prognostic impact of hypertension in patients hospitalized with systolic HF. Methods: Pooled analysis of data from three Korean observational studies was performed. Patients ≥18 years hospitalized with systolic HF (ejection fraction ≤45%) (n = 3538) were compared for the incidence of 1-year all-cause mortality according to the presence of preexisting hypertension and SBP quartiles on admission. Results: Patients with hypertension (prevalence, 51.6%) presented more often with diabetes (43.9% vs. 23.0%, p < 0.001) and chronic kidney disease (14.1% vs. 5.7%, p < 0.001). During the 1-year follow-up, patients with hypertension showed similar cumulative incidences of all-cause mortality as those without hypertension (8.3% vs. 8.4%, p = 0.900). Conversely, patients with higher SBP on admission had a lower incidence of all-cause death (quartile 4 vs. 1: 6.7% vs. 11.3%, p for trend = 0.004). In the multivariate analysis, an increase in SBP of 10 mmHg was associated with an 8.5% risk reduction of all-cause death (hazard ratio: 0.915, 95% confidence interval: 0.853-0.981, p = 0.013). Conclusions: Higher SBP on admission was independently associated with a lower risk of 1-year all-cause mortality in systolic HF.

AB - Background: Higher systolic blood pressure (SBP) has been reported to be associated with a better prognosis in heart failure (HF) patients. This study aimed to investigate the prognostic impact of hypertension in patients hospitalized with systolic HF. Methods: Pooled analysis of data from three Korean observational studies was performed. Patients ≥18 years hospitalized with systolic HF (ejection fraction ≤45%) (n = 3538) were compared for the incidence of 1-year all-cause mortality according to the presence of preexisting hypertension and SBP quartiles on admission. Results: Patients with hypertension (prevalence, 51.6%) presented more often with diabetes (43.9% vs. 23.0%, p < 0.001) and chronic kidney disease (14.1% vs. 5.7%, p < 0.001). During the 1-year follow-up, patients with hypertension showed similar cumulative incidences of all-cause mortality as those without hypertension (8.3% vs. 8.4%, p = 0.900). Conversely, patients with higher SBP on admission had a lower incidence of all-cause death (quartile 4 vs. 1: 6.7% vs. 11.3%, p for trend = 0.004). In the multivariate analysis, an increase in SBP of 10 mmHg was associated with an 8.5% risk reduction of all-cause death (hazard ratio: 0.915, 95% confidence interval: 0.853-0.981, p = 0.013). Conclusions: Higher SBP on admission was independently associated with a lower risk of 1-year all-cause mortality in systolic HF.

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U2 - 10.1016/j.jjcc.2015.08.005

DO - 10.1016/j.jjcc.2015.08.005

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EP - 423

JO - Journal of cardiography. Supplement

JF - Journal of cardiography. Supplement

SN - 0914-5087

IS - 5

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