Prognostic impact of preexisting hypertension and high systolic blood pressure at admission in patients hospitalized for systolic heart failure

Ji Hyun Lee, Jun Won Lee, Young Jin Youn, Min Soo Ahn, Sung Gyun Ahn, Jang Young Kim, Seung Hwan Lee, Junghan Yoon, Jaewon Oh, Seok Min Kang, Eun Seok Jeon, Dong Ju Choi, Kyu Hyung Ryu, Byung Su Yoo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Higher systolic blood pressure (SBP) has been reported to be associated with a better prognosis in heart failure (HF) patients. This study aimed to investigate the prognostic impact of hypertension in patients hospitalized with systolic HF. Methods: Pooled analysis of data from three Korean observational studies was performed. Patients ≥18 years hospitalized with systolic HF (ejection fraction ≤45%) (n = 3538) were compared for the incidence of 1-year all-cause mortality according to the presence of preexisting hypertension and SBP quartiles on admission. Results: Patients with hypertension (prevalence, 51.6%) presented more often with diabetes (43.9% vs. 23.0%, p < 0.001) and chronic kidney disease (14.1% vs. 5.7%, p < 0.001). During the 1-year follow-up, patients with hypertension showed similar cumulative incidences of all-cause mortality as those without hypertension (8.3% vs. 8.4%, p = 0.900). Conversely, patients with higher SBP on admission had a lower incidence of all-cause death (quartile 4 vs. 1: 6.7% vs. 11.3%, p for trend = 0.004). In the multivariate analysis, an increase in SBP of 10 mmHg was associated with an 8.5% risk reduction of all-cause death (hazard ratio: 0.915, 95% confidence interval: 0.853-0.981, p = 0.013). Conclusions: Higher SBP on admission was independently associated with a lower risk of 1-year all-cause mortality in systolic HF.

Original languageEnglish
Pages (from-to)418-423
Number of pages6
JournalJournal of Cardiology
Volume67
Issue number5
DOIs
Publication statusPublished - 2016 May 1

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Systolic Heart Failure
Patient Admission
Blood Pressure
Hypertension
Mortality
Cause of Death
Incidence
Risk Reduction Behavior
Chronic Renal Insufficiency
Observational Studies
Multivariate Analysis
Heart Failure
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{a3c977687a464e75b09a2d0a1fab6a96,
title = "Prognostic impact of preexisting hypertension and high systolic blood pressure at admission in patients hospitalized for systolic heart failure",
abstract = "Background: Higher systolic blood pressure (SBP) has been reported to be associated with a better prognosis in heart failure (HF) patients. This study aimed to investigate the prognostic impact of hypertension in patients hospitalized with systolic HF. Methods: Pooled analysis of data from three Korean observational studies was performed. Patients ≥18 years hospitalized with systolic HF (ejection fraction ≤45{\%}) (n = 3538) were compared for the incidence of 1-year all-cause mortality according to the presence of preexisting hypertension and SBP quartiles on admission. Results: Patients with hypertension (prevalence, 51.6{\%}) presented more often with diabetes (43.9{\%} vs. 23.0{\%}, p < 0.001) and chronic kidney disease (14.1{\%} vs. 5.7{\%}, p < 0.001). During the 1-year follow-up, patients with hypertension showed similar cumulative incidences of all-cause mortality as those without hypertension (8.3{\%} vs. 8.4{\%}, p = 0.900). Conversely, patients with higher SBP on admission had a lower incidence of all-cause death (quartile 4 vs. 1: 6.7{\%} vs. 11.3{\%}, p for trend = 0.004). In the multivariate analysis, an increase in SBP of 10 mmHg was associated with an 8.5{\%} risk reduction of all-cause death (hazard ratio: 0.915, 95{\%} confidence interval: 0.853-0.981, p = 0.013). Conclusions: Higher SBP on admission was independently associated with a lower risk of 1-year all-cause mortality in systolic HF.",
author = "Lee, {Ji Hyun} and Lee, {Jun Won} and Youn, {Young Jin} and Ahn, {Min Soo} and Ahn, {Sung Gyun} and Kim, {Jang Young} and Lee, {Seung Hwan} and Junghan Yoon and Jaewon Oh and Kang, {Seok Min} and Jeon, {Eun Seok} and Choi, {Dong Ju} and Ryu, {Kyu Hyung} and Yoo, {Byung Su}",
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Prognostic impact of preexisting hypertension and high systolic blood pressure at admission in patients hospitalized for systolic heart failure. / Lee, Ji Hyun; Lee, Jun Won; Youn, Young Jin; Ahn, Min Soo; Ahn, Sung Gyun; Kim, Jang Young; Lee, Seung Hwan; Yoon, Junghan; Oh, Jaewon; Kang, Seok Min; Jeon, Eun Seok; Choi, Dong Ju; Ryu, Kyu Hyung; Yoo, Byung Su.

In: Journal of Cardiology, Vol. 67, No. 5, 01.05.2016, p. 418-423.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostic impact of preexisting hypertension and high systolic blood pressure at admission in patients hospitalized for systolic heart failure

AU - Lee, Ji Hyun

AU - Lee, Jun Won

AU - Youn, Young Jin

AU - Ahn, Min Soo

AU - Ahn, Sung Gyun

AU - Kim, Jang Young

AU - Lee, Seung Hwan

AU - Yoon, Junghan

AU - Oh, Jaewon

AU - Kang, Seok Min

AU - Jeon, Eun Seok

AU - Choi, Dong Ju

AU - Ryu, Kyu Hyung

AU - Yoo, Byung Su

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Background: Higher systolic blood pressure (SBP) has been reported to be associated with a better prognosis in heart failure (HF) patients. This study aimed to investigate the prognostic impact of hypertension in patients hospitalized with systolic HF. Methods: Pooled analysis of data from three Korean observational studies was performed. Patients ≥18 years hospitalized with systolic HF (ejection fraction ≤45%) (n = 3538) were compared for the incidence of 1-year all-cause mortality according to the presence of preexisting hypertension and SBP quartiles on admission. Results: Patients with hypertension (prevalence, 51.6%) presented more often with diabetes (43.9% vs. 23.0%, p < 0.001) and chronic kidney disease (14.1% vs. 5.7%, p < 0.001). During the 1-year follow-up, patients with hypertension showed similar cumulative incidences of all-cause mortality as those without hypertension (8.3% vs. 8.4%, p = 0.900). Conversely, patients with higher SBP on admission had a lower incidence of all-cause death (quartile 4 vs. 1: 6.7% vs. 11.3%, p for trend = 0.004). In the multivariate analysis, an increase in SBP of 10 mmHg was associated with an 8.5% risk reduction of all-cause death (hazard ratio: 0.915, 95% confidence interval: 0.853-0.981, p = 0.013). Conclusions: Higher SBP on admission was independently associated with a lower risk of 1-year all-cause mortality in systolic HF.

AB - Background: Higher systolic blood pressure (SBP) has been reported to be associated with a better prognosis in heart failure (HF) patients. This study aimed to investigate the prognostic impact of hypertension in patients hospitalized with systolic HF. Methods: Pooled analysis of data from three Korean observational studies was performed. Patients ≥18 years hospitalized with systolic HF (ejection fraction ≤45%) (n = 3538) were compared for the incidence of 1-year all-cause mortality according to the presence of preexisting hypertension and SBP quartiles on admission. Results: Patients with hypertension (prevalence, 51.6%) presented more often with diabetes (43.9% vs. 23.0%, p < 0.001) and chronic kidney disease (14.1% vs. 5.7%, p < 0.001). During the 1-year follow-up, patients with hypertension showed similar cumulative incidences of all-cause mortality as those without hypertension (8.3% vs. 8.4%, p = 0.900). Conversely, patients with higher SBP on admission had a lower incidence of all-cause death (quartile 4 vs. 1: 6.7% vs. 11.3%, p for trend = 0.004). In the multivariate analysis, an increase in SBP of 10 mmHg was associated with an 8.5% risk reduction of all-cause death (hazard ratio: 0.915, 95% confidence interval: 0.853-0.981, p = 0.013). Conclusions: Higher SBP on admission was independently associated with a lower risk of 1-year all-cause mortality in systolic HF.

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