Abstract
Background: Higher systolic blood pressure (SBP) has been reported to be associated with a better prognosis in heart failure (HF) patients. This study aimed to investigate the prognostic impact of hypertension in patients hospitalized with systolic HF. Methods: Pooled analysis of data from three Korean observational studies was performed. Patients ≥18 years hospitalized with systolic HF (ejection fraction ≤45%) (n = 3538) were compared for the incidence of 1-year all-cause mortality according to the presence of preexisting hypertension and SBP quartiles on admission. Results: Patients with hypertension (prevalence, 51.6%) presented more often with diabetes (43.9% vs. 23.0%, p < 0.001) and chronic kidney disease (14.1% vs. 5.7%, p < 0.001). During the 1-year follow-up, patients with hypertension showed similar cumulative incidences of all-cause mortality as those without hypertension (8.3% vs. 8.4%, p = 0.900). Conversely, patients with higher SBP on admission had a lower incidence of all-cause death (quartile 4 vs. 1: 6.7% vs. 11.3%, p for trend = 0.004). In the multivariate analysis, an increase in SBP of 10 mmHg was associated with an 8.5% risk reduction of all-cause death (hazard ratio: 0.915, 95% confidence interval: 0.853-0.981, p = 0.013). Conclusions: Higher SBP on admission was independently associated with a lower risk of 1-year all-cause mortality in systolic HF.
| Original language | English |
|---|---|
| Pages (from-to) | 418-423 |
| Number of pages | 6 |
| Journal | Journal of Cardiology |
| Volume | 67 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2016 May 1 |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
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Prognostic impact of preexisting hypertension and high systolic blood pressure at admission in patients hospitalized for systolic heart failure. / Lee, Ji Hyun; Lee, Jun Won; Youn, Young Jin; Ahn, Min Soo; Ahn, Sung Gyun; Kim, Jang Young; Lee, Seung Hwan; Yoon, Junghan; Oh, Jaewon; Kang, Seok Min; Jeon, Eun Seok; Choi, Dong Ju; Ryu, Kyu Hyung; Yoo, Byung Su.
In: Journal of Cardiology, Vol. 67, No. 5, 01.05.2016, p. 418-423.Research output: Contribution to journal › Article
TY - JOUR
T1 - Prognostic impact of preexisting hypertension and high systolic blood pressure at admission in patients hospitalized for systolic heart failure
AU - Lee, Ji Hyun
AU - Lee, Jun Won
AU - Youn, Young Jin
AU - Ahn, Min Soo
AU - Ahn, Sung Gyun
AU - Kim, Jang Young
AU - Lee, Seung Hwan
AU - Yoon, Junghan
AU - Oh, Jaewon
AU - Kang, Seok Min
AU - Jeon, Eun Seok
AU - Choi, Dong Ju
AU - Ryu, Kyu Hyung
AU - Yoo, Byung Su
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Background: Higher systolic blood pressure (SBP) has been reported to be associated with a better prognosis in heart failure (HF) patients. This study aimed to investigate the prognostic impact of hypertension in patients hospitalized with systolic HF. Methods: Pooled analysis of data from three Korean observational studies was performed. Patients ≥18 years hospitalized with systolic HF (ejection fraction ≤45%) (n = 3538) were compared for the incidence of 1-year all-cause mortality according to the presence of preexisting hypertension and SBP quartiles on admission. Results: Patients with hypertension (prevalence, 51.6%) presented more often with diabetes (43.9% vs. 23.0%, p < 0.001) and chronic kidney disease (14.1% vs. 5.7%, p < 0.001). During the 1-year follow-up, patients with hypertension showed similar cumulative incidences of all-cause mortality as those without hypertension (8.3% vs. 8.4%, p = 0.900). Conversely, patients with higher SBP on admission had a lower incidence of all-cause death (quartile 4 vs. 1: 6.7% vs. 11.3%, p for trend = 0.004). In the multivariate analysis, an increase in SBP of 10 mmHg was associated with an 8.5% risk reduction of all-cause death (hazard ratio: 0.915, 95% confidence interval: 0.853-0.981, p = 0.013). Conclusions: Higher SBP on admission was independently associated with a lower risk of 1-year all-cause mortality in systolic HF.
AB - Background: Higher systolic blood pressure (SBP) has been reported to be associated with a better prognosis in heart failure (HF) patients. This study aimed to investigate the prognostic impact of hypertension in patients hospitalized with systolic HF. Methods: Pooled analysis of data from three Korean observational studies was performed. Patients ≥18 years hospitalized with systolic HF (ejection fraction ≤45%) (n = 3538) were compared for the incidence of 1-year all-cause mortality according to the presence of preexisting hypertension and SBP quartiles on admission. Results: Patients with hypertension (prevalence, 51.6%) presented more often with diabetes (43.9% vs. 23.0%, p < 0.001) and chronic kidney disease (14.1% vs. 5.7%, p < 0.001). During the 1-year follow-up, patients with hypertension showed similar cumulative incidences of all-cause mortality as those without hypertension (8.3% vs. 8.4%, p = 0.900). Conversely, patients with higher SBP on admission had a lower incidence of all-cause death (quartile 4 vs. 1: 6.7% vs. 11.3%, p for trend = 0.004). In the multivariate analysis, an increase in SBP of 10 mmHg was associated with an 8.5% risk reduction of all-cause death (hazard ratio: 0.915, 95% confidence interval: 0.853-0.981, p = 0.013). Conclusions: Higher SBP on admission was independently associated with a lower risk of 1-year all-cause mortality in systolic HF.
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U2 - 10.1016/j.jjcc.2015.08.005
DO - 10.1016/j.jjcc.2015.08.005
M3 - Article
C2 - 26359710
AN - SCOPUS:84940978125
VL - 67
SP - 418
EP - 423
JO - Journal of Cardiology
JF - Journal of Cardiology
SN - 0914-5087
IS - 5
ER -