Prognostic impact of the lymph node ratio in rectal cancer patients who underwent preoperative chemoradiation

Jeonghyun Kang, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim

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28 Citations (Scopus)

Abstract

Aim: The purpose of this study was to investigate the prognostic impact of the lymph node ratio (LNR) in ypN-positive rectal cancer patients who received preoperative chemoradiation (preop-CRT). Methods: A total of 75 patients diagnosed as node-positive after undergoing preop-CRT followed by curative resection were enrolled. Patients were categorized into two groups based on their median LNR, 0.143. Results: The median metastatic and retrieved lymph node numbers were 2.0 (range: 1-79) and 18.0 (range: 5-80). Abdominoperineal resection, circumferential resection margin involvement and higher LNR were proven to be independent adverse prognostic factors affecting survival in the multivariate analysis including LNR as a covariate. Of the 47 patients with ypN1, 35 (74.5%) showed a lower LNR (N1G1) and 12 (25.5%) showed a higher LNR (N1G2). The N1G1 group showed better overall survival than the N1G2 group (P = 0.018). There was no difference between the survival rates of the N1G2 group and the ypN2 group (P = 0.987). Conclusions: LNR is an independent prognostic factor after preop-CRT for rectal cancer. LNR showed better prognosis stratification than the ypN stage. Therefore, LNR should be considered as an additional prognostic factor in node-positive rectal cancer after preop-CRT.

Original languageEnglish
Pages (from-to)53-58
Number of pages6
JournalJournal of surgical oncology
Volume104
Issue number1
DOIs
Publication statusPublished - 2011 Jul 1

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Rectal Neoplasms
Lymph Nodes
Survival
Multivariate Analysis
Survival Rate

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Kang, Jeonghyun ; Hur, Hyuk ; Min, Byung Soh ; Lee, Kang Young ; Kim, Nam Kyu. / Prognostic impact of the lymph node ratio in rectal cancer patients who underwent preoperative chemoradiation. In: Journal of surgical oncology. 2011 ; Vol. 104, No. 1. pp. 53-58.
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abstract = "Aim: The purpose of this study was to investigate the prognostic impact of the lymph node ratio (LNR) in ypN-positive rectal cancer patients who received preoperative chemoradiation (preop-CRT). Methods: A total of 75 patients diagnosed as node-positive after undergoing preop-CRT followed by curative resection were enrolled. Patients were categorized into two groups based on their median LNR, 0.143. Results: The median metastatic and retrieved lymph node numbers were 2.0 (range: 1-79) and 18.0 (range: 5-80). Abdominoperineal resection, circumferential resection margin involvement and higher LNR were proven to be independent adverse prognostic factors affecting survival in the multivariate analysis including LNR as a covariate. Of the 47 patients with ypN1, 35 (74.5{\%}) showed a lower LNR (N1G1) and 12 (25.5{\%}) showed a higher LNR (N1G2). The N1G1 group showed better overall survival than the N1G2 group (P = 0.018). There was no difference between the survival rates of the N1G2 group and the ypN2 group (P = 0.987). Conclusions: LNR is an independent prognostic factor after preop-CRT for rectal cancer. LNR showed better prognosis stratification than the ypN stage. Therefore, LNR should be considered as an additional prognostic factor in node-positive rectal cancer after preop-CRT.",
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Prognostic impact of the lymph node ratio in rectal cancer patients who underwent preoperative chemoradiation. / Kang, Jeonghyun; Hur, Hyuk; Min, Byung Soh; Lee, Kang Young; Kim, Nam Kyu.

In: Journal of surgical oncology, Vol. 104, No. 1, 01.07.2011, p. 53-58.

Research output: Contribution to journalArticle

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