Prognostic implication of programmed cell death 1 protein and its ligand expressions in endometrial cancer

Jisup Kim, Sinae Kim, Hye Sun Lee, Wookyeom Yang, Hanbyoul Cho, Doo Byung Chay, Seong Jin Cho, Soonwon Hong, Jae Hoon Kim

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: Monoclonal antibodies targeting programmed cell death-1 (PD-1)/programmed death ligand 1 (PD-L1) demonstrated promising clinical response. The predictive/prognostic value of PD-1/PD-L1 immunohistochemistry (IHC) has been evaluated in many cancer types. However, the prognostic value of PD-1/PD-L1 IHC has not been evaluated in endometrial cancer. Methods: We conducted a retrospective study to quantify the IHC CD8, PD-1, and PD-L1 expressions in immune cells at center of tumor (CT), invasive margin (IM), and/or tumor cell in 183 primary endometrial cancer samples from a single cohort, followed by their reciprocal combinations, including compartmental differences, and correlated them with overall survival (OS) and progression-free survival (PFS). Results: In repeated Cox multivariable models adjusted by clinicoimmunopathologic factors, high CT-PD-L1 was an independent adverse prognostic factor for PFS in all patients and in the microsatellite-stable subgroup. Immune marker ratios revealed independently shorter PFS for high CT-PD-L1/CT-CD8 and CT-PD-L1/CT-PD-1 ratios. Classification of endometrial cancer into four groups based on CT-CD8 and CT-PD-L1 revealed significantly different survival among groups. Conclusions: The high PD-L1/CD8 ratio and the high expression of PD-L1 on immune cells were independent poor prognostic factors for PFS in endometrial cancer, providing insights into the tumor microenvironment.

Original languageEnglish
Pages (from-to)381-387
Number of pages7
JournalGynecologic Oncology
Volume149
Issue number2
DOIs
Publication statusPublished - 2018 May

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynaecology

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