Prognostic implications of serum lipid metabolism over time during sepsis

Sang Hoon Lee, Moo Suk Park, Byung Hoon Park, Won Jai Jung, In Seon Lee, Song Yee Kim, Eun Young Kim, Ji Ye Jung, youngae kang, Young Sam Kim, Se Kyu Kim, Joon Chang, Kyung Soo Chung

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background. Despite extensive research and an improved standard of care, sepsis remains a disorder with a high mortality rate. Sepsis is accompanied by severe metabolic alterations. Methods. We evaluated 117 patients with sepsis (severe sepsis [n=19] and septic shock [n=98]) who were admitted to the intensive care unit. Serum cholesterol, triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), free fatty acid (FFA), and apolipoprotein (Apo) A-I levels were measured on days 0, 1, 3, and 7. Results. Nonsurvivors had low levels of cholesterol, TG, HDL, LDL, and Apo A-I on days 0, 1, 3, and 7. In a linear mixed model analysis, the variations in TG, LDL, FFA, and Apo A-I levels over time differed significantly between the groups (p=0.043, p=0.020, p=0.005, and p=0.015, resp.). According to multivariate analysis, TG levels and SOFA scores were associated with mortality on days 0 and 1 (p=0.018 and p=0.008, resp.). Conclusions. Our study illustrated that TG levels are associated with mortality in patients with sepsis. This may be attributable to alterations in serum lipid metabolism during sepsis, thus modulating the host response to inflammation in critically ill patients.

Original languageEnglish
Article number789298
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - 2015 Jan 1

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Lipid Metabolism
Apolipoprotein A-I
Sepsis
Triglycerides
HDL Lipoproteins
Serum
LDL Lipoproteins
Nonesterified Fatty Acids
Cholesterol
Intensive care units
HDL Cholesterol
Mortality
Standard of Care
Septic Shock
Critical Illness
Intensive Care Units
Linear Models
Multivariate Analysis
Inflammation
Research

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Lee, S. H., Park, M. S., Park, B. H., Jung, W. J., Lee, I. S., Kim, S. Y., ... Chung, K. S. (2015). Prognostic implications of serum lipid metabolism over time during sepsis. BioMed Research International, 2015, [789298]. https://doi.org/10.1155/2015/789298
Lee, Sang Hoon ; Park, Moo Suk ; Park, Byung Hoon ; Jung, Won Jai ; Lee, In Seon ; Kim, Song Yee ; Kim, Eun Young ; Jung, Ji Ye ; kang, youngae ; Kim, Young Sam ; Kim, Se Kyu ; Chang, Joon ; Chung, Kyung Soo. / Prognostic implications of serum lipid metabolism over time during sepsis. In: BioMed Research International. 2015 ; Vol. 2015.
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abstract = "Background. Despite extensive research and an improved standard of care, sepsis remains a disorder with a high mortality rate. Sepsis is accompanied by severe metabolic alterations. Methods. We evaluated 117 patients with sepsis (severe sepsis [n=19] and septic shock [n=98]) who were admitted to the intensive care unit. Serum cholesterol, triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), free fatty acid (FFA), and apolipoprotein (Apo) A-I levels were measured on days 0, 1, 3, and 7. Results. Nonsurvivors had low levels of cholesterol, TG, HDL, LDL, and Apo A-I on days 0, 1, 3, and 7. In a linear mixed model analysis, the variations in TG, LDL, FFA, and Apo A-I levels over time differed significantly between the groups (p=0.043, p=0.020, p=0.005, and p=0.015, resp.). According to multivariate analysis, TG levels and SOFA scores were associated with mortality on days 0 and 1 (p=0.018 and p=0.008, resp.). Conclusions. Our study illustrated that TG levels are associated with mortality in patients with sepsis. This may be attributable to alterations in serum lipid metabolism during sepsis, thus modulating the host response to inflammation in critically ill patients.",
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Lee, SH, Park, MS, Park, BH, Jung, WJ, Lee, IS, Kim, SY, Kim, EY, Jung, JY, kang, Y, Kim, YS, Kim, SK, Chang, J & Chung, KS 2015, 'Prognostic implications of serum lipid metabolism over time during sepsis', BioMed Research International, vol. 2015, 789298. https://doi.org/10.1155/2015/789298

Prognostic implications of serum lipid metabolism over time during sepsis. / Lee, Sang Hoon; Park, Moo Suk; Park, Byung Hoon; Jung, Won Jai; Lee, In Seon; Kim, Song Yee; Kim, Eun Young; Jung, Ji Ye; kang, youngae; Kim, Young Sam; Kim, Se Kyu; Chang, Joon; Chung, Kyung Soo.

In: BioMed Research International, Vol. 2015, 789298, 01.01.2015.

Research output: Contribution to journalArticle

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T1 - Prognostic implications of serum lipid metabolism over time during sepsis

AU - Lee, Sang Hoon

AU - Park, Moo Suk

AU - Park, Byung Hoon

AU - Jung, Won Jai

AU - Lee, In Seon

AU - Kim, Song Yee

AU - Kim, Eun Young

AU - Jung, Ji Ye

AU - kang, youngae

AU - Kim, Young Sam

AU - Kim, Se Kyu

AU - Chang, Joon

AU - Chung, Kyung Soo

PY - 2015/1/1

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N2 - Background. Despite extensive research and an improved standard of care, sepsis remains a disorder with a high mortality rate. Sepsis is accompanied by severe metabolic alterations. Methods. We evaluated 117 patients with sepsis (severe sepsis [n=19] and septic shock [n=98]) who were admitted to the intensive care unit. Serum cholesterol, triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), free fatty acid (FFA), and apolipoprotein (Apo) A-I levels were measured on days 0, 1, 3, and 7. Results. Nonsurvivors had low levels of cholesterol, TG, HDL, LDL, and Apo A-I on days 0, 1, 3, and 7. In a linear mixed model analysis, the variations in TG, LDL, FFA, and Apo A-I levels over time differed significantly between the groups (p=0.043, p=0.020, p=0.005, and p=0.015, resp.). According to multivariate analysis, TG levels and SOFA scores were associated with mortality on days 0 and 1 (p=0.018 and p=0.008, resp.). Conclusions. Our study illustrated that TG levels are associated with mortality in patients with sepsis. This may be attributable to alterations in serum lipid metabolism during sepsis, thus modulating the host response to inflammation in critically ill patients.

AB - Background. Despite extensive research and an improved standard of care, sepsis remains a disorder with a high mortality rate. Sepsis is accompanied by severe metabolic alterations. Methods. We evaluated 117 patients with sepsis (severe sepsis [n=19] and septic shock [n=98]) who were admitted to the intensive care unit. Serum cholesterol, triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), free fatty acid (FFA), and apolipoprotein (Apo) A-I levels were measured on days 0, 1, 3, and 7. Results. Nonsurvivors had low levels of cholesterol, TG, HDL, LDL, and Apo A-I on days 0, 1, 3, and 7. In a linear mixed model analysis, the variations in TG, LDL, FFA, and Apo A-I levels over time differed significantly between the groups (p=0.043, p=0.020, p=0.005, and p=0.015, resp.). According to multivariate analysis, TG levels and SOFA scores were associated with mortality on days 0 and 1 (p=0.018 and p=0.008, resp.). Conclusions. Our study illustrated that TG levels are associated with mortality in patients with sepsis. This may be attributable to alterations in serum lipid metabolism during sepsis, thus modulating the host response to inflammation in critically ill patients.

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