Prognostic implications of the immunophenotype in biphenotypic acute leukemia

Je Hwan Lee, Yoo Hong Min, Chul Won Chung, Byoung Kook Kim, Hwi Joong Yoon, Deog Yeon Jo, Ho Jin Shin, Soo Mee Bang, Jong Ho Won, Dae Young Zang, Hyeoung Joon Kim, Hyun Sook Chi, Kyoo Hyung Lee, June Won Cheong, Jin Seok Kim, Sun Hee Kim, Seonyang Park, Su Yon Park, Joo Seop Chung, Jae Hoon LeeChan Jeoung Park

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Abstract

The present study retrospectively analyzed clinicopathological and clinical data from 43 adult patients with biphenotypic acute leukemia (BAL) from 11 Korean institutes. The incidence of BAL was 2.1% among acute leukemias. In terms of immunophenotype, 31 patients had myeloid plus B-lymphoid (M + B), 10 had myeloid plus T-lymphoid (M + T), one had myeloid plus B-lymphoid plus T-lymphoid (M + B + T), and one had B-lymphoid plus T-lymphoid (B + T). Patients with M + T phenotype had significantly lower CR rate (55.6% vs. 88.0%, P = 0.039) and lower overall survival (0% vs. 33.9% at 5 years, P = 0.028) than those with M + B phenotype. Our results suggest that immunophenotype has prognostic implications in adult patients with BAL.

Original languageEnglish
Pages (from-to)700-709
Number of pages10
JournalLeukemia and Lymphoma
Volume49
Issue number4
DOIs
Publication statusPublished - 2008 Apr 1

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All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Lee, J. H., Min, Y. H., Chung, C. W., Kim, B. K., Yoon, H. J., Jo, D. Y., Shin, H. J., Bang, S. M., Won, J. H., Zang, D. Y., Kim, H. J., Chi, H. S., Lee, K. H., Cheong, J. W., Kim, J. S., Kim, S. H., Park, S., Park, S. Y., Chung, J. S., ... Park, C. J. (2008). Prognostic implications of the immunophenotype in biphenotypic acute leukemia. Leukemia and Lymphoma, 49(4), 700-709. https://doi.org/10.1080/10428190701843247