Prognostic implications of the immunophenotype in biphenotypic acute leukemia

Je Hwan Lee, Yoo Hong Min, Chul Won Chung, Byoung Kook Kim, Hwi Joong Yoon, Deog Yeon Jo, Ho Jin Shin, Soo Mee Bang, Jong Ho Won, Dae Young Zang, Hyeoung Joon Kim, Hyun Sook Chi, Kyoo Hyung Lee, June Won Cheong, Jin Seok Kim, Sun Hee Kim, Seonyang Park, Su Yon Park, Joo Seop Chung, Jae Hoon LeeChan Jeoung Park

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Abstract

The present study retrospectively analyzed clinicopathological and clinical data from 43 adult patients with biphenotypic acute leukemia (BAL) from 11 Korean institutes. The incidence of BAL was 2.1% among acute leukemias. In terms of immunophenotype, 31 patients had myeloid plus B-lymphoid (M + B), 10 had myeloid plus T-lymphoid (M + T), one had myeloid plus B-lymphoid plus T-lymphoid (M + B + T), and one had B-lymphoid plus T-lymphoid (B + T). Patients with M + T phenotype had significantly lower CR rate (55.6% vs. 88.0%, P = 0.039) and lower overall survival (0% vs. 33.9% at 5 years, P = 0.028) than those with M + B phenotype. Our results suggest that immunophenotype has prognostic implications in adult patients with BAL.

Original languageEnglish
Pages (from-to)700-709
Number of pages10
JournalLeukemia and Lymphoma
Volume49
Issue number4
DOIs
Publication statusPublished - 2008 Apr 1

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Biphenotypic Acute Leukemia
Phenotype
Leukemia
Survival
Incidence

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Lee, J. H., Min, Y. H., Chung, C. W., Kim, B. K., Yoon, H. J., Jo, D. Y., ... Park, C. J. (2008). Prognostic implications of the immunophenotype in biphenotypic acute leukemia. Leukemia and Lymphoma, 49(4), 700-709. https://doi.org/10.1080/10428190701843247
Lee, Je Hwan ; Min, Yoo Hong ; Chung, Chul Won ; Kim, Byoung Kook ; Yoon, Hwi Joong ; Jo, Deog Yeon ; Shin, Ho Jin ; Bang, Soo Mee ; Won, Jong Ho ; Zang, Dae Young ; Kim, Hyeoung Joon ; Chi, Hyun Sook ; Lee, Kyoo Hyung ; Cheong, June Won ; Kim, Jin Seok ; Kim, Sun Hee ; Park, Seonyang ; Park, Su Yon ; Chung, Joo Seop ; Lee, Jae Hoon ; Park, Chan Jeoung. / Prognostic implications of the immunophenotype in biphenotypic acute leukemia. In: Leukemia and Lymphoma. 2008 ; Vol. 49, No. 4. pp. 700-709.
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abstract = "The present study retrospectively analyzed clinicopathological and clinical data from 43 adult patients with biphenotypic acute leukemia (BAL) from 11 Korean institutes. The incidence of BAL was 2.1{\%} among acute leukemias. In terms of immunophenotype, 31 patients had myeloid plus B-lymphoid (M + B), 10 had myeloid plus T-lymphoid (M + T), one had myeloid plus B-lymphoid plus T-lymphoid (M + B + T), and one had B-lymphoid plus T-lymphoid (B + T). Patients with M + T phenotype had significantly lower CR rate (55.6{\%} vs. 88.0{\%}, P = 0.039) and lower overall survival (0{\%} vs. 33.9{\%} at 5 years, P = 0.028) than those with M + B phenotype. Our results suggest that immunophenotype has prognostic implications in adult patients with BAL.",
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Lee, JH, Min, YH, Chung, CW, Kim, BK, Yoon, HJ, Jo, DY, Shin, HJ, Bang, SM, Won, JH, Zang, DY, Kim, HJ, Chi, HS, Lee, KH, Cheong, JW, Kim, JS, Kim, SH, Park, S, Park, SY, Chung, JS, Lee, JH & Park, CJ 2008, 'Prognostic implications of the immunophenotype in biphenotypic acute leukemia', Leukemia and Lymphoma, vol. 49, no. 4, pp. 700-709. https://doi.org/10.1080/10428190701843247

Prognostic implications of the immunophenotype in biphenotypic acute leukemia. / Lee, Je Hwan; Min, Yoo Hong; Chung, Chul Won; Kim, Byoung Kook; Yoon, Hwi Joong; Jo, Deog Yeon; Shin, Ho Jin; Bang, Soo Mee; Won, Jong Ho; Zang, Dae Young; Kim, Hyeoung Joon; Chi, Hyun Sook; Lee, Kyoo Hyung; Cheong, June Won; Kim, Jin Seok; Kim, Sun Hee; Park, Seonyang; Park, Su Yon; Chung, Joo Seop; Lee, Jae Hoon; Park, Chan Jeoung.

In: Leukemia and Lymphoma, Vol. 49, No. 4, 01.04.2008, p. 700-709.

Research output: Contribution to journalArticle

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T1 - Prognostic implications of the immunophenotype in biphenotypic acute leukemia

AU - Lee, Je Hwan

AU - Min, Yoo Hong

AU - Chung, Chul Won

AU - Kim, Byoung Kook

AU - Yoon, Hwi Joong

AU - Jo, Deog Yeon

AU - Shin, Ho Jin

AU - Bang, Soo Mee

AU - Won, Jong Ho

AU - Zang, Dae Young

AU - Kim, Hyeoung Joon

AU - Chi, Hyun Sook

AU - Lee, Kyoo Hyung

AU - Cheong, June Won

AU - Kim, Jin Seok

AU - Kim, Sun Hee

AU - Park, Seonyang

AU - Park, Su Yon

AU - Chung, Joo Seop

AU - Lee, Jae Hoon

AU - Park, Chan Jeoung

PY - 2008/4/1

Y1 - 2008/4/1

N2 - The present study retrospectively analyzed clinicopathological and clinical data from 43 adult patients with biphenotypic acute leukemia (BAL) from 11 Korean institutes. The incidence of BAL was 2.1% among acute leukemias. In terms of immunophenotype, 31 patients had myeloid plus B-lymphoid (M + B), 10 had myeloid plus T-lymphoid (M + T), one had myeloid plus B-lymphoid plus T-lymphoid (M + B + T), and one had B-lymphoid plus T-lymphoid (B + T). Patients with M + T phenotype had significantly lower CR rate (55.6% vs. 88.0%, P = 0.039) and lower overall survival (0% vs. 33.9% at 5 years, P = 0.028) than those with M + B phenotype. Our results suggest that immunophenotype has prognostic implications in adult patients with BAL.

AB - The present study retrospectively analyzed clinicopathological and clinical data from 43 adult patients with biphenotypic acute leukemia (BAL) from 11 Korean institutes. The incidence of BAL was 2.1% among acute leukemias. In terms of immunophenotype, 31 patients had myeloid plus B-lymphoid (M + B), 10 had myeloid plus T-lymphoid (M + T), one had myeloid plus B-lymphoid plus T-lymphoid (M + B + T), and one had B-lymphoid plus T-lymphoid (B + T). Patients with M + T phenotype had significantly lower CR rate (55.6% vs. 88.0%, P = 0.039) and lower overall survival (0% vs. 33.9% at 5 years, P = 0.028) than those with M + B phenotype. Our results suggest that immunophenotype has prognostic implications in adult patients with BAL.

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