Prognostic model to predict survival outcome for curatively resected liposarcoma: A multi-institutional experience

Yoon Jung Oh, Seong Yoon Yi, Ki Hyang Kim, Yong Jin Cho, Seung Hoon Beum, Young Han Lee, Jinsuck Suh, Hyuk Hur, Kyung Sik Kim, Sung Hoon Kim, Youngdeuk Choi, Kyoo Ho Shin, Hyun Jung Jun, Sung Joo Kim, Jeeyun Lee, Se Hoon Park, Sung Hoon Noh, SunYoung Rha, Hyo Song Kim

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: We performed this study to analyze the clinical features and prognosis of Korean patients with liposarcoma. Patients & Methods: Between October 1986 and April 2013, 231 patients who were diagnosed with liposarcoma by histologic examination were enrolled in this study. Results: The distribution of histologic subtypes was well-differentiated (n = 97, 42%), myxoid (n = 74, 32%), dedifferentiated (n = 32, 13.9%), pleomorphic (n = 15, 6.5%), and round-cell liposarcoma (n = 13, 5.6%). The majority of liposarcomas were located in the lower extremities (35.5%) and retroperitoneum (34.2%). Prognosis was worse for the trunk group compared with the extremity group (median disease-free survival [DFS] 3.3 vs. 9.9 years, respectively, P <0.001). Median DFS was significantly worse in patients with high grade histology compared to those with low grade histology (16.9% vs. 65.7%, P <0.001). The independent prognostic factors associated with survival were histology (hazard ratio [HR] 3.01; 95% confidence interval [CI], 1.82-4.97; P <0.001) and primary site (HR 1.80; 95% CI, 1.12-2.89; P = 0.015). Three risk groups with different survival outcomes were identified: group 1 (n = 98), no risk factors; group 2 (n = 92), one risk factor; and group 3 (n = 41), two risk factors. Conclusions: Histologic subtype and primary site were independent prognostic factors for curatively resected liposarcoma. A prognostic model for patients with liposarcoma clarified distinct groups of patients with good prognostic discrimination.

Original languageEnglish
Pages (from-to)1174-1180
Number of pages7
JournalJournal of Cancer
Volume7
Issue number9
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Liposarcoma
Survival
Histology
Disease-Free Survival
Confidence Intervals
Lower Extremity
Extremities

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Oh, Y. J., Yi, S. Y., Kim, K. H., Cho, Y. J., Beum, S. H., Lee, Y. H., ... Kim, H. S. (2016). Prognostic model to predict survival outcome for curatively resected liposarcoma: A multi-institutional experience. Journal of Cancer, 7(9), 1174-1180. https://doi.org/10.7150/jca.15243
Oh, Yoon Jung ; Yi, Seong Yoon ; Kim, Ki Hyang ; Cho, Yong Jin ; Beum, Seung Hoon ; Lee, Young Han ; Suh, Jinsuck ; Hur, Hyuk ; Kim, Kyung Sik ; Kim, Sung Hoon ; Choi, Youngdeuk ; Shin, Kyoo Ho ; Jun, Hyun Jung ; Kim, Sung Joo ; Lee, Jeeyun ; Park, Se Hoon ; Noh, Sung Hoon ; Rha, SunYoung ; Kim, Hyo Song. / Prognostic model to predict survival outcome for curatively resected liposarcoma : A multi-institutional experience. In: Journal of Cancer. 2016 ; Vol. 7, No. 9. pp. 1174-1180.
@article{56413c8352c246d8960f4ae401a87fd7,
title = "Prognostic model to predict survival outcome for curatively resected liposarcoma: A multi-institutional experience",
abstract = "Purpose: We performed this study to analyze the clinical features and prognosis of Korean patients with liposarcoma. Patients & Methods: Between October 1986 and April 2013, 231 patients who were diagnosed with liposarcoma by histologic examination were enrolled in this study. Results: The distribution of histologic subtypes was well-differentiated (n = 97, 42{\%}), myxoid (n = 74, 32{\%}), dedifferentiated (n = 32, 13.9{\%}), pleomorphic (n = 15, 6.5{\%}), and round-cell liposarcoma (n = 13, 5.6{\%}). The majority of liposarcomas were located in the lower extremities (35.5{\%}) and retroperitoneum (34.2{\%}). Prognosis was worse for the trunk group compared with the extremity group (median disease-free survival [DFS] 3.3 vs. 9.9 years, respectively, P <0.001). Median DFS was significantly worse in patients with high grade histology compared to those with low grade histology (16.9{\%} vs. 65.7{\%}, P <0.001). The independent prognostic factors associated with survival were histology (hazard ratio [HR] 3.01; 95{\%} confidence interval [CI], 1.82-4.97; P <0.001) and primary site (HR 1.80; 95{\%} CI, 1.12-2.89; P = 0.015). Three risk groups with different survival outcomes were identified: group 1 (n = 98), no risk factors; group 2 (n = 92), one risk factor; and group 3 (n = 41), two risk factors. Conclusions: Histologic subtype and primary site were independent prognostic factors for curatively resected liposarcoma. A prognostic model for patients with liposarcoma clarified distinct groups of patients with good prognostic discrimination.",
author = "Oh, {Yoon Jung} and Yi, {Seong Yoon} and Kim, {Ki Hyang} and Cho, {Yong Jin} and Beum, {Seung Hoon} and Lee, {Young Han} and Jinsuck Suh and Hyuk Hur and Kim, {Kyung Sik} and Kim, {Sung Hoon} and Youngdeuk Choi and Shin, {Kyoo Ho} and Jun, {Hyun Jung} and Kim, {Sung Joo} and Jeeyun Lee and Park, {Se Hoon} and Noh, {Sung Hoon} and SunYoung Rha and Kim, {Hyo Song}",
year = "2016",
month = "1",
day = "1",
doi = "10.7150/jca.15243",
language = "English",
volume = "7",
pages = "1174--1180",
journal = "Journal of Cancer",
issn = "1837-9664",
publisher = "Ivyspring International Publisher",
number = "9",

}

Oh, YJ, Yi, SY, Kim, KH, Cho, YJ, Beum, SH, Lee, YH, Suh, J, Hur, H, Kim, KS, Kim, SH, Choi, Y, Shin, KH, Jun, HJ, Kim, SJ, Lee, J, Park, SH, Noh, SH, Rha, S & Kim, HS 2016, 'Prognostic model to predict survival outcome for curatively resected liposarcoma: A multi-institutional experience', Journal of Cancer, vol. 7, no. 9, pp. 1174-1180. https://doi.org/10.7150/jca.15243

Prognostic model to predict survival outcome for curatively resected liposarcoma : A multi-institutional experience. / Oh, Yoon Jung; Yi, Seong Yoon; Kim, Ki Hyang; Cho, Yong Jin; Beum, Seung Hoon; Lee, Young Han; Suh, Jinsuck; Hur, Hyuk; Kim, Kyung Sik; Kim, Sung Hoon; Choi, Youngdeuk; Shin, Kyoo Ho; Jun, Hyun Jung; Kim, Sung Joo; Lee, Jeeyun; Park, Se Hoon; Noh, Sung Hoon; Rha, SunYoung; Kim, Hyo Song.

In: Journal of Cancer, Vol. 7, No. 9, 01.01.2016, p. 1174-1180.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostic model to predict survival outcome for curatively resected liposarcoma

T2 - A multi-institutional experience

AU - Oh, Yoon Jung

AU - Yi, Seong Yoon

AU - Kim, Ki Hyang

AU - Cho, Yong Jin

AU - Beum, Seung Hoon

AU - Lee, Young Han

AU - Suh, Jinsuck

AU - Hur, Hyuk

AU - Kim, Kyung Sik

AU - Kim, Sung Hoon

AU - Choi, Youngdeuk

AU - Shin, Kyoo Ho

AU - Jun, Hyun Jung

AU - Kim, Sung Joo

AU - Lee, Jeeyun

AU - Park, Se Hoon

AU - Noh, Sung Hoon

AU - Rha, SunYoung

AU - Kim, Hyo Song

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Purpose: We performed this study to analyze the clinical features and prognosis of Korean patients with liposarcoma. Patients & Methods: Between October 1986 and April 2013, 231 patients who were diagnosed with liposarcoma by histologic examination were enrolled in this study. Results: The distribution of histologic subtypes was well-differentiated (n = 97, 42%), myxoid (n = 74, 32%), dedifferentiated (n = 32, 13.9%), pleomorphic (n = 15, 6.5%), and round-cell liposarcoma (n = 13, 5.6%). The majority of liposarcomas were located in the lower extremities (35.5%) and retroperitoneum (34.2%). Prognosis was worse for the trunk group compared with the extremity group (median disease-free survival [DFS] 3.3 vs. 9.9 years, respectively, P <0.001). Median DFS was significantly worse in patients with high grade histology compared to those with low grade histology (16.9% vs. 65.7%, P <0.001). The independent prognostic factors associated with survival were histology (hazard ratio [HR] 3.01; 95% confidence interval [CI], 1.82-4.97; P <0.001) and primary site (HR 1.80; 95% CI, 1.12-2.89; P = 0.015). Three risk groups with different survival outcomes were identified: group 1 (n = 98), no risk factors; group 2 (n = 92), one risk factor; and group 3 (n = 41), two risk factors. Conclusions: Histologic subtype and primary site were independent prognostic factors for curatively resected liposarcoma. A prognostic model for patients with liposarcoma clarified distinct groups of patients with good prognostic discrimination.

AB - Purpose: We performed this study to analyze the clinical features and prognosis of Korean patients with liposarcoma. Patients & Methods: Between October 1986 and April 2013, 231 patients who were diagnosed with liposarcoma by histologic examination were enrolled in this study. Results: The distribution of histologic subtypes was well-differentiated (n = 97, 42%), myxoid (n = 74, 32%), dedifferentiated (n = 32, 13.9%), pleomorphic (n = 15, 6.5%), and round-cell liposarcoma (n = 13, 5.6%). The majority of liposarcomas were located in the lower extremities (35.5%) and retroperitoneum (34.2%). Prognosis was worse for the trunk group compared with the extremity group (median disease-free survival [DFS] 3.3 vs. 9.9 years, respectively, P <0.001). Median DFS was significantly worse in patients with high grade histology compared to those with low grade histology (16.9% vs. 65.7%, P <0.001). The independent prognostic factors associated with survival were histology (hazard ratio [HR] 3.01; 95% confidence interval [CI], 1.82-4.97; P <0.001) and primary site (HR 1.80; 95% CI, 1.12-2.89; P = 0.015). Three risk groups with different survival outcomes were identified: group 1 (n = 98), no risk factors; group 2 (n = 92), one risk factor; and group 3 (n = 41), two risk factors. Conclusions: Histologic subtype and primary site were independent prognostic factors for curatively resected liposarcoma. A prognostic model for patients with liposarcoma clarified distinct groups of patients with good prognostic discrimination.

UR - http://www.scopus.com/inward/record.url?scp=84990214356&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84990214356&partnerID=8YFLogxK

U2 - 10.7150/jca.15243

DO - 10.7150/jca.15243

M3 - Article

AN - SCOPUS:84990214356

VL - 7

SP - 1174

EP - 1180

JO - Journal of Cancer

JF - Journal of Cancer

SN - 1837-9664

IS - 9

ER -