Prognostic nutritional index is associated with disease severity and relapse in ANCA-associated vasculitis

Sung Soo Ahn, Seung Min Jung, Jason Jungsik Song, Yong Beom Park, Sang Won Lee

Research output: Contribution to journalArticle

Abstract

Aim: The prognostic nutritional index (PNI), calculated by serum albumin and peripheral blood lymphocyte count, is considered to reflect immune-related nutritional status. In this study, we first investigated the clinical significance of PNI in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Method: Medical records of 160 patients classified as AAV from October 2000 to September 2017 were reviewed. We calculated the Birmingham vasculitis activity score (BVAS) and collected laboratory data including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, white blood cell, lymphocyte, and platelet counts, and serum albumin, aspartate aminotransferase, and alanine aminotransferase levels at diagnosis. PNI at diagnosis was calculated as (10 × serum albumin [g/dL] + 0.005 × lymphocyte count [/mm 3 ]). Associations between laboratory variables, PNI, and BVAS were assessed by linear regression analyses, and Cox proportional hazard analysis was used to evaluate factors associated with disease relapse. Results: The mean age was 55.2 years and 48 patients (30.0%) were male. In univariable linear regression analysis, BVAS was positively correlated with ESR and CRP and negatively with lymphocyte count, serum albumin, and PNI (r = −0.307). In multivariable linear regression analysis, among ESR, CRP, and PNI, PNI was associated with BVAS (β = −0.299). PNI also significantly correlated with the included laboratory data. In Cox proportional hazard analysis, myeloperoxidase—antineutrophil cytoplasmic antibody positivity (odds ratio [OR] 2.875, P = 0.003) and PNI ≤36.75 (OR 2.066, P = 0.042) revealed to be independent predictors of disease relapse during the follow-up period. Conclusions: Prognostic nutritional index at diagnosis might be useful for assessing disease severity and predicting the prognosis of AAV patients.

Original languageEnglish
Pages (from-to)797-804
Number of pages8
JournalInternational Journal of Rheumatic Diseases
Volume22
Issue number5
DOIs
Publication statusPublished - 2019 May

Fingerprint

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Nutrition Assessment
Vasculitis
Recurrence
Blood Sedimentation
Lymphocyte Count
Serum Albumin
C-Reactive Protein
Linear Models
Regression Analysis
Antibodies
Odds Ratio
Antineutrophil Cytoplasmic Antibodies
Aspartate Aminotransferases
Nutritional Status
Alanine Transaminase
Platelet Count
Leukocyte Count
Medical Records
Albumins

All Science Journal Classification (ASJC) codes

  • Rheumatology

Cite this

Ahn, Sung Soo ; Jung, Seung Min ; Song, Jason Jungsik ; Park, Yong Beom ; Lee, Sang Won. / Prognostic nutritional index is associated with disease severity and relapse in ANCA-associated vasculitis. In: International Journal of Rheumatic Diseases. 2019 ; Vol. 22, No. 5. pp. 797-804.
@article{06ca6b9443cc4f8381c239ad54dadd25,
title = "Prognostic nutritional index is associated with disease severity and relapse in ANCA-associated vasculitis",
abstract = "Aim: The prognostic nutritional index (PNI), calculated by serum albumin and peripheral blood lymphocyte count, is considered to reflect immune-related nutritional status. In this study, we first investigated the clinical significance of PNI in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Method: Medical records of 160 patients classified as AAV from October 2000 to September 2017 were reviewed. We calculated the Birmingham vasculitis activity score (BVAS) and collected laboratory data including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, white blood cell, lymphocyte, and platelet counts, and serum albumin, aspartate aminotransferase, and alanine aminotransferase levels at diagnosis. PNI at diagnosis was calculated as (10 × serum albumin [g/dL] + 0.005 × lymphocyte count [/mm 3 ]). Associations between laboratory variables, PNI, and BVAS were assessed by linear regression analyses, and Cox proportional hazard analysis was used to evaluate factors associated with disease relapse. Results: The mean age was 55.2 years and 48 patients (30.0{\%}) were male. In univariable linear regression analysis, BVAS was positively correlated with ESR and CRP and negatively with lymphocyte count, serum albumin, and PNI (r = −0.307). In multivariable linear regression analysis, among ESR, CRP, and PNI, PNI was associated with BVAS (β = −0.299). PNI also significantly correlated with the included laboratory data. In Cox proportional hazard analysis, myeloperoxidase—antineutrophil cytoplasmic antibody positivity (odds ratio [OR] 2.875, P = 0.003) and PNI ≤36.75 (OR 2.066, P = 0.042) revealed to be independent predictors of disease relapse during the follow-up period. Conclusions: Prognostic nutritional index at diagnosis might be useful for assessing disease severity and predicting the prognosis of AAV patients.",
author = "Ahn, {Sung Soo} and Jung, {Seung Min} and Song, {Jason Jungsik} and Park, {Yong Beom} and Lee, {Sang Won}",
year = "2019",
month = "5",
doi = "10.1111/1756-185X.13507",
language = "English",
volume = "22",
pages = "797--804",
journal = "International Journal of Rheumatic Diseases",
issn = "1756-1841",
publisher = "Wiley-Blackwell",
number = "5",

}

Prognostic nutritional index is associated with disease severity and relapse in ANCA-associated vasculitis. / Ahn, Sung Soo; Jung, Seung Min; Song, Jason Jungsik; Park, Yong Beom; Lee, Sang Won.

In: International Journal of Rheumatic Diseases, Vol. 22, No. 5, 05.2019, p. 797-804.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostic nutritional index is associated with disease severity and relapse in ANCA-associated vasculitis

AU - Ahn, Sung Soo

AU - Jung, Seung Min

AU - Song, Jason Jungsik

AU - Park, Yong Beom

AU - Lee, Sang Won

PY - 2019/5

Y1 - 2019/5

N2 - Aim: The prognostic nutritional index (PNI), calculated by serum albumin and peripheral blood lymphocyte count, is considered to reflect immune-related nutritional status. In this study, we first investigated the clinical significance of PNI in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Method: Medical records of 160 patients classified as AAV from October 2000 to September 2017 were reviewed. We calculated the Birmingham vasculitis activity score (BVAS) and collected laboratory data including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, white blood cell, lymphocyte, and platelet counts, and serum albumin, aspartate aminotransferase, and alanine aminotransferase levels at diagnosis. PNI at diagnosis was calculated as (10 × serum albumin [g/dL] + 0.005 × lymphocyte count [/mm 3 ]). Associations between laboratory variables, PNI, and BVAS were assessed by linear regression analyses, and Cox proportional hazard analysis was used to evaluate factors associated with disease relapse. Results: The mean age was 55.2 years and 48 patients (30.0%) were male. In univariable linear regression analysis, BVAS was positively correlated with ESR and CRP and negatively with lymphocyte count, serum albumin, and PNI (r = −0.307). In multivariable linear regression analysis, among ESR, CRP, and PNI, PNI was associated with BVAS (β = −0.299). PNI also significantly correlated with the included laboratory data. In Cox proportional hazard analysis, myeloperoxidase—antineutrophil cytoplasmic antibody positivity (odds ratio [OR] 2.875, P = 0.003) and PNI ≤36.75 (OR 2.066, P = 0.042) revealed to be independent predictors of disease relapse during the follow-up period. Conclusions: Prognostic nutritional index at diagnosis might be useful for assessing disease severity and predicting the prognosis of AAV patients.

AB - Aim: The prognostic nutritional index (PNI), calculated by serum albumin and peripheral blood lymphocyte count, is considered to reflect immune-related nutritional status. In this study, we first investigated the clinical significance of PNI in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Method: Medical records of 160 patients classified as AAV from October 2000 to September 2017 were reviewed. We calculated the Birmingham vasculitis activity score (BVAS) and collected laboratory data including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, white blood cell, lymphocyte, and platelet counts, and serum albumin, aspartate aminotransferase, and alanine aminotransferase levels at diagnosis. PNI at diagnosis was calculated as (10 × serum albumin [g/dL] + 0.005 × lymphocyte count [/mm 3 ]). Associations between laboratory variables, PNI, and BVAS were assessed by linear regression analyses, and Cox proportional hazard analysis was used to evaluate factors associated with disease relapse. Results: The mean age was 55.2 years and 48 patients (30.0%) were male. In univariable linear regression analysis, BVAS was positively correlated with ESR and CRP and negatively with lymphocyte count, serum albumin, and PNI (r = −0.307). In multivariable linear regression analysis, among ESR, CRP, and PNI, PNI was associated with BVAS (β = −0.299). PNI also significantly correlated with the included laboratory data. In Cox proportional hazard analysis, myeloperoxidase—antineutrophil cytoplasmic antibody positivity (odds ratio [OR] 2.875, P = 0.003) and PNI ≤36.75 (OR 2.066, P = 0.042) revealed to be independent predictors of disease relapse during the follow-up period. Conclusions: Prognostic nutritional index at diagnosis might be useful for assessing disease severity and predicting the prognosis of AAV patients.

UR - http://www.scopus.com/inward/record.url?scp=85061200770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061200770&partnerID=8YFLogxK

U2 - 10.1111/1756-185X.13507

DO - 10.1111/1756-185X.13507

M3 - Article

C2 - 30729693

AN - SCOPUS:85061200770

VL - 22

SP - 797

EP - 804

JO - International Journal of Rheumatic Diseases

JF - International Journal of Rheumatic Diseases

SN - 1756-1841

IS - 5

ER -