Prognostic role and implications of mutation status of tumor suppressor gene ARID1A in cancer: A systematic review and meta-analysis

Claudio Luchini, Nicola Veronese, Marco Solmi, Hanbyoul Cho, Jae Hoon Kim, Angela Chou, Anthony J. Gill, Sheila F. Faraj, Alcides Chaux, George J. Netto, Kentaro Nakayama, Satoru Kyo, Soo Young Lee, Duck Woo Kim, George M. Yousef, Andreas Scorilas, Gregg S. Nelson, Martin Köbel, Steve E. Kalloger, David F. SchaefferHai Bo Yan, Feng Liu, Yoshihito Yokoyama, Xianyu Zhang, Da Pang, Zsuzsanna Lichner, Giuseppe Sergi, Enzo Manzato, Paola Capelli, Laura D. Wood, Aldo Scarpa, Christoph U. Correll

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Loss of the tumor suppressor gene AT-rich interactive domain-containing protein 1A (ARID1A) has been demonstrated in several cancers, but its prognostic role is unknown. We aimed to investigate the risk associated with loss of ARID1A (ARID1A-) for all-cause mortality, cancer-specific mortality and recurrence of disease in subjects with cancer. PubMed and SCOPUS search from database inception until 01/31/2015 without language restriction was conducted, contacting authors for unpublished data. Eligible were prospective studies reporting data on prognostic parameters in subjects with cancer, comparing participants with presence of ARID1A (ARID1A+) vs. ARID1A-, assessed either via immunohistochemistry (loss of expression) or with genetic testing (presence of mutation). Data were summarized using risk ratios (RR) for number of deaths/recurrences and hazard ratios (HR) for time-dependent risk related to ARID1A- adjusted for potential confounders. Of 136 hits, 25 studies with 5,651 participants (28 cohorts; ARID1A-: n = 1,701; ARID1A+: n = 3,950), with a mean follow-up period of 4.7 ± 1.8 years, were meta-analyzed. Compared to ARID1A+, ARID1A- significantly increased cancer-specific mortality (studies = 3; RR = 1.55, 95% confidence interval (CI) = 1.19-2.00, I2 = 31%). Using HRs adjusted for potential confounders, ARID1A- was associated with a greater risk of cancer-specific mortality (studies = 2; HR = 2.55, 95%CI = 1.19-5.45, I2 = 19%) and cancer recurrence (studies = 10; HR = 1.93, 95%CI = 1.22-3.05, I2 = 76%). On the basis of these results, we have demonstrated that loss of ARID1A shortened time to cancer-specific mortality, and to recurrence of cancer when adjusting for potential confounders. For its role, this gene should be considered as an important potential target for personalized medicine in cancer treatment.

Original languageEnglish
Pages (from-to)39088-39097
Number of pages10
JournalOncotarget
Volume6
Issue number36
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Tumor Suppressor Genes
Meta-Analysis
Mutation
Neoplasms
Mortality
Recurrence
Confidence Intervals
Protein Domains
Odds Ratio
Precision Medicine
Genetic Testing
PubMed
Research Design
Language
Immunohistochemistry
Databases
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Luchini, Claudio ; Veronese, Nicola ; Solmi, Marco ; Cho, Hanbyoul ; Kim, Jae Hoon ; Chou, Angela ; Gill, Anthony J. ; Faraj, Sheila F. ; Chaux, Alcides ; Netto, George J. ; Nakayama, Kentaro ; Kyo, Satoru ; Lee, Soo Young ; Kim, Duck Woo ; Yousef, George M. ; Scorilas, Andreas ; Nelson, Gregg S. ; Köbel, Martin ; Kalloger, Steve E. ; Schaeffer, David F. ; Yan, Hai Bo ; Liu, Feng ; Yokoyama, Yoshihito ; Zhang, Xianyu ; Pang, Da ; Lichner, Zsuzsanna ; Sergi, Giuseppe ; Manzato, Enzo ; Capelli, Paola ; Wood, Laura D. ; Scarpa, Aldo ; Correll, Christoph U. / Prognostic role and implications of mutation status of tumor suppressor gene ARID1A in cancer : A systematic review and meta-analysis. In: Oncotarget. 2015 ; Vol. 6, No. 36. pp. 39088-39097.
@article{b0488efad11a4b4b813c07c3f4aee2e5,
title = "Prognostic role and implications of mutation status of tumor suppressor gene ARID1A in cancer: A systematic review and meta-analysis",
abstract = "Loss of the tumor suppressor gene AT-rich interactive domain-containing protein 1A (ARID1A) has been demonstrated in several cancers, but its prognostic role is unknown. We aimed to investigate the risk associated with loss of ARID1A (ARID1A-) for all-cause mortality, cancer-specific mortality and recurrence of disease in subjects with cancer. PubMed and SCOPUS search from database inception until 01/31/2015 without language restriction was conducted, contacting authors for unpublished data. Eligible were prospective studies reporting data on prognostic parameters in subjects with cancer, comparing participants with presence of ARID1A (ARID1A+) vs. ARID1A-, assessed either via immunohistochemistry (loss of expression) or with genetic testing (presence of mutation). Data were summarized using risk ratios (RR) for number of deaths/recurrences and hazard ratios (HR) for time-dependent risk related to ARID1A- adjusted for potential confounders. Of 136 hits, 25 studies with 5,651 participants (28 cohorts; ARID1A-: n = 1,701; ARID1A+: n = 3,950), with a mean follow-up period of 4.7 ± 1.8 years, were meta-analyzed. Compared to ARID1A+, ARID1A- significantly increased cancer-specific mortality (studies = 3; RR = 1.55, 95{\%} confidence interval (CI) = 1.19-2.00, I2 = 31{\%}). Using HRs adjusted for potential confounders, ARID1A- was associated with a greater risk of cancer-specific mortality (studies = 2; HR = 2.55, 95{\%}CI = 1.19-5.45, I2 = 19{\%}) and cancer recurrence (studies = 10; HR = 1.93, 95{\%}CI = 1.22-3.05, I2 = 76{\%}). On the basis of these results, we have demonstrated that loss of ARID1A shortened time to cancer-specific mortality, and to recurrence of cancer when adjusting for potential confounders. For its role, this gene should be considered as an important potential target for personalized medicine in cancer treatment.",
author = "Claudio Luchini and Nicola Veronese and Marco Solmi and Hanbyoul Cho and Kim, {Jae Hoon} and Angela Chou and Gill, {Anthony J.} and Faraj, {Sheila F.} and Alcides Chaux and Netto, {George J.} and Kentaro Nakayama and Satoru Kyo and Lee, {Soo Young} and Kim, {Duck Woo} and Yousef, {George M.} and Andreas Scorilas and Nelson, {Gregg S.} and Martin K{\"o}bel and Kalloger, {Steve E.} and Schaeffer, {David F.} and Yan, {Hai Bo} and Feng Liu and Yoshihito Yokoyama and Xianyu Zhang and Da Pang and Zsuzsanna Lichner and Giuseppe Sergi and Enzo Manzato and Paola Capelli and Wood, {Laura D.} and Aldo Scarpa and Correll, {Christoph U.}",
year = "2015",
month = "1",
day = "1",
doi = "10.18632/oncotarget.5142",
language = "English",
volume = "6",
pages = "39088--39097",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals",
number = "36",

}

Luchini, C, Veronese, N, Solmi, M, Cho, H, Kim, JH, Chou, A, Gill, AJ, Faraj, SF, Chaux, A, Netto, GJ, Nakayama, K, Kyo, S, Lee, SY, Kim, DW, Yousef, GM, Scorilas, A, Nelson, GS, Köbel, M, Kalloger, SE, Schaeffer, DF, Yan, HB, Liu, F, Yokoyama, Y, Zhang, X, Pang, D, Lichner, Z, Sergi, G, Manzato, E, Capelli, P, Wood, LD, Scarpa, A & Correll, CU 2015, 'Prognostic role and implications of mutation status of tumor suppressor gene ARID1A in cancer: A systematic review and meta-analysis', Oncotarget, vol. 6, no. 36, pp. 39088-39097. https://doi.org/10.18632/oncotarget.5142

Prognostic role and implications of mutation status of tumor suppressor gene ARID1A in cancer : A systematic review and meta-analysis. / Luchini, Claudio; Veronese, Nicola; Solmi, Marco; Cho, Hanbyoul; Kim, Jae Hoon; Chou, Angela; Gill, Anthony J.; Faraj, Sheila F.; Chaux, Alcides; Netto, George J.; Nakayama, Kentaro; Kyo, Satoru; Lee, Soo Young; Kim, Duck Woo; Yousef, George M.; Scorilas, Andreas; Nelson, Gregg S.; Köbel, Martin; Kalloger, Steve E.; Schaeffer, David F.; Yan, Hai Bo; Liu, Feng; Yokoyama, Yoshihito; Zhang, Xianyu; Pang, Da; Lichner, Zsuzsanna; Sergi, Giuseppe; Manzato, Enzo; Capelli, Paola; Wood, Laura D.; Scarpa, Aldo; Correll, Christoph U.

In: Oncotarget, Vol. 6, No. 36, 01.01.2015, p. 39088-39097.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostic role and implications of mutation status of tumor suppressor gene ARID1A in cancer

T2 - A systematic review and meta-analysis

AU - Luchini, Claudio

AU - Veronese, Nicola

AU - Solmi, Marco

AU - Cho, Hanbyoul

AU - Kim, Jae Hoon

AU - Chou, Angela

AU - Gill, Anthony J.

AU - Faraj, Sheila F.

AU - Chaux, Alcides

AU - Netto, George J.

AU - Nakayama, Kentaro

AU - Kyo, Satoru

AU - Lee, Soo Young

AU - Kim, Duck Woo

AU - Yousef, George M.

AU - Scorilas, Andreas

AU - Nelson, Gregg S.

AU - Köbel, Martin

AU - Kalloger, Steve E.

AU - Schaeffer, David F.

AU - Yan, Hai Bo

AU - Liu, Feng

AU - Yokoyama, Yoshihito

AU - Zhang, Xianyu

AU - Pang, Da

AU - Lichner, Zsuzsanna

AU - Sergi, Giuseppe

AU - Manzato, Enzo

AU - Capelli, Paola

AU - Wood, Laura D.

AU - Scarpa, Aldo

AU - Correll, Christoph U.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Loss of the tumor suppressor gene AT-rich interactive domain-containing protein 1A (ARID1A) has been demonstrated in several cancers, but its prognostic role is unknown. We aimed to investigate the risk associated with loss of ARID1A (ARID1A-) for all-cause mortality, cancer-specific mortality and recurrence of disease in subjects with cancer. PubMed and SCOPUS search from database inception until 01/31/2015 without language restriction was conducted, contacting authors for unpublished data. Eligible were prospective studies reporting data on prognostic parameters in subjects with cancer, comparing participants with presence of ARID1A (ARID1A+) vs. ARID1A-, assessed either via immunohistochemistry (loss of expression) or with genetic testing (presence of mutation). Data were summarized using risk ratios (RR) for number of deaths/recurrences and hazard ratios (HR) for time-dependent risk related to ARID1A- adjusted for potential confounders. Of 136 hits, 25 studies with 5,651 participants (28 cohorts; ARID1A-: n = 1,701; ARID1A+: n = 3,950), with a mean follow-up period of 4.7 ± 1.8 years, were meta-analyzed. Compared to ARID1A+, ARID1A- significantly increased cancer-specific mortality (studies = 3; RR = 1.55, 95% confidence interval (CI) = 1.19-2.00, I2 = 31%). Using HRs adjusted for potential confounders, ARID1A- was associated with a greater risk of cancer-specific mortality (studies = 2; HR = 2.55, 95%CI = 1.19-5.45, I2 = 19%) and cancer recurrence (studies = 10; HR = 1.93, 95%CI = 1.22-3.05, I2 = 76%). On the basis of these results, we have demonstrated that loss of ARID1A shortened time to cancer-specific mortality, and to recurrence of cancer when adjusting for potential confounders. For its role, this gene should be considered as an important potential target for personalized medicine in cancer treatment.

AB - Loss of the tumor suppressor gene AT-rich interactive domain-containing protein 1A (ARID1A) has been demonstrated in several cancers, but its prognostic role is unknown. We aimed to investigate the risk associated with loss of ARID1A (ARID1A-) for all-cause mortality, cancer-specific mortality and recurrence of disease in subjects with cancer. PubMed and SCOPUS search from database inception until 01/31/2015 without language restriction was conducted, contacting authors for unpublished data. Eligible were prospective studies reporting data on prognostic parameters in subjects with cancer, comparing participants with presence of ARID1A (ARID1A+) vs. ARID1A-, assessed either via immunohistochemistry (loss of expression) or with genetic testing (presence of mutation). Data were summarized using risk ratios (RR) for number of deaths/recurrences and hazard ratios (HR) for time-dependent risk related to ARID1A- adjusted for potential confounders. Of 136 hits, 25 studies with 5,651 participants (28 cohorts; ARID1A-: n = 1,701; ARID1A+: n = 3,950), with a mean follow-up period of 4.7 ± 1.8 years, were meta-analyzed. Compared to ARID1A+, ARID1A- significantly increased cancer-specific mortality (studies = 3; RR = 1.55, 95% confidence interval (CI) = 1.19-2.00, I2 = 31%). Using HRs adjusted for potential confounders, ARID1A- was associated with a greater risk of cancer-specific mortality (studies = 2; HR = 2.55, 95%CI = 1.19-5.45, I2 = 19%) and cancer recurrence (studies = 10; HR = 1.93, 95%CI = 1.22-3.05, I2 = 76%). On the basis of these results, we have demonstrated that loss of ARID1A shortened time to cancer-specific mortality, and to recurrence of cancer when adjusting for potential confounders. For its role, this gene should be considered as an important potential target for personalized medicine in cancer treatment.

UR - http://www.scopus.com/inward/record.url?scp=84948755634&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948755634&partnerID=8YFLogxK

U2 - 10.18632/oncotarget.5142

DO - 10.18632/oncotarget.5142

M3 - Article

C2 - 26384299

AN - SCOPUS:84948755634

VL - 6

SP - 39088

EP - 39097

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

IS - 36

ER -