Prognostic significance of body mass index and prognostic nutritional index in stage II/III gastric cancer

Su Hyung Park, Sejin Lee, Jeong Ho Song, Seohee Choi, Minah Cho, In Gyu Kwon, Taeil Son, Hyoung Il Kim, Jae Ho Cheong, Woo Jin Hyung, Seung Ho Choi, Sung Hoon Noh, Yoon Young Choi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Introduction: Preoperative body weight and nutritional status are related to prognosis in patients with gastric cancer; however, the prognostic impact of postoperative in these variables is unclear. We aimed to investigate the association of preoperative/postoperative body mass index (BMI) and prognostic nutritional index (PNI) with prognosis in patients with gastric cancer. Materials and methods: We retrospectively 1868 patients with stage II/III gastric cancer treated with gastrectomy between January 2006 and December 2010. We divided the populations into 3 groups according to BMI; underweight, normal, and overweight. Patients were divided into 3 groups according to BMI (underweight, normal-weight, overweight). PNI was classified into low and high (cutoff value; 49.7). The association of preoperative BMI/PNI and their changes (6 months postoperatively) with clinicopathologic characteristics were evaluated. Results: Preoperative underweight and low PNI were related to poor prognosis (log-rank p < 0.001 for both). There was a positive correlation between preoperative BMI and PNI (mean preoperative PNI: 51.13 [underweight], 53.37 [normal-weight], and 55.16 [overweight]; p < 0.001). Preoperative BMI and PNI were independent prognostic factors for disease-free survival along with age and TNM stage (p < 0.001 for both). BMI changes from normal-weight to underweight and from overweight to normal/underweight were related to poor prognosis (log-rank p = 0.021 and p = 0.013, respectively). PNI changes were related to prognosis in both the preoperative low and high PNI groups (p < 0.001 and p = 0.019, respectively). Conclusion: Preoperative BMI and PNI and their postoperative changes are related to prognosis in patients with stage II/III gastric cancer. Careful nutritional intervention after gastrectomy can improve prognosis.

Original languageEnglish
Pages (from-to)620-625
Number of pages6
JournalEuropean Journal of Surgical Oncology
Volume46
Issue number4
DOIs
Publication statusPublished - 2020 Apr

Bibliographical note

Funding Information:
None.

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Fingerprint Dive into the research topics of 'Prognostic significance of body mass index and prognostic nutritional index in stage II/III gastric cancer'. Together they form a unique fingerprint.

Cite this