Prognostic significance of DNA quantification by flow cytometry in ovarian tumors

Y. T. Kim, M. Zhao, S. H. Kim, C. S. Lee, J. H. Kim, J. W. Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: The objective of our study is to evaluate prognostic significance of DNA quantification by flow cytometry in ovarian tumor. Methods: A prospective analysis was performed on 56 ovarian tumor patients treated in the Yonsei Medical Center from Feb. 2000 to Jan. 2003. Results: Regarding the association between tumor grade and the DNA quantitative analysis, as tumor grade increased, the quantity of aneuploid cells and S-phase fraction (SPF) increased. In addition, SPF was increased significantly in the advanced staged patients (P=0.04) and SPF was significantly increased in aneuploid tumors (P=0.03). The overall survival rate was poor for patients with aneuploid tumors and for patients with tumors showing over SPF (10%). Conclusion: Our data demonstrated that the prognosis was poor for patients with aneuploid cancers or increased SPF. Therefore, DNA quantification by flow cytometry may provide important information for predicting the prognosis of the disease.

Original languageEnglish
Pages (from-to)286-291
Number of pages6
JournalInternational Journal of Gynecology and Obstetrics
Volume88
Issue number3
DOIs
Publication statusPublished - 2005 Mar

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

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