Prognostic significance of interventricular septal thickness in patients with AL amyloidosis

Hyunsoo Cho, Soo Jeong Kim, Chi Young Shim, Geu Ru Hong, Jong Won Ha, Yu Ri Kim, Woo Ick Yang, Haerim Chung, Ji Eun Jang, June Won Cheong, Yoo Hong Min, Jin Seok Kim

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Abstract

The major prognostic determinant of immunoglobulin light chain (AL) amyloidosis is cardiac involvement. However, the role of interventricular septal thickness (IVST), which reflects the extent of cardiac involvement, remains unclear. Therefore, we analyzed 77 patients with newly diagnosed AL amyloidosis and evaluated the prognostic role of IVST. Fifty patients (64.9%) had cardiac involvement and 17 patients (22.1%) showed IVST >15 mm. Among all patients, the revised Mayo Clinic Stage III–IV and IVST >15 mm were independently associated with inferior overall survival (OS) in a multivariable analysis. IVST >15 mm was also adversely prognostic for OS in a subgroup of advanced-stage (revised Mayo Clinic stage III–IV) patients in a multivariable analysis (P < 0.001). Furthermore, advanced-stage patients with IVST >15 mm did not show survival benefit from treatment with bortezomib-based regimens and/or autologous stem-cell transplantation (ASCT). Our study demonstrated that IVST >15 mm is adversely prognostic independent of the revised Mayo Clinic staging system in patients with AL amyloidosis. In addition, the degree of IVST might be used as a useful prognostic indicator that can guide the management of patients with AL amyloidosis especially at an advanced stage.

Original languageEnglish
Pages (from-to)36-43
Number of pages8
JournalLeukemia Research
Volume60
DOIs
Publication statusPublished - 2017 Sep

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Cho, H., Kim, S. J., Shim, C. Y., Hong, G. R., Ha, J. W., Kim, Y. R., Yang, W. I., Chung, H., Jang, J. E., Cheong, J. W., Min, Y. H., & Kim, J. S. (2017). Prognostic significance of interventricular septal thickness in patients with AL amyloidosis. Leukemia Research, 60, 36-43. https://doi.org/10.1016/j.leukres.2017.06.008