Prognostic significance of interventricular septal thickness in patients with AL amyloidosis

Hyunsoo Cho, Soo Jeong Kim, ChiYoung Shim, Geu Ru Hong, Jong Won Ha, Yu Ri Kim, Woo Ick Yang, Haerim Chung, Ji Eun Jang, June Won Cheong, Yoo Hong Min, Jinseok Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The major prognostic determinant of immunoglobulin light chain (AL) amyloidosis is cardiac involvement. However, the role of interventricular septal thickness (IVST), which reflects the extent of cardiac involvement, remains unclear. Therefore, we analyzed 77 patients with newly diagnosed AL amyloidosis and evaluated the prognostic role of IVST. Fifty patients (64.9%) had cardiac involvement and 17 patients (22.1%) showed IVST >15 mm. Among all patients, the revised Mayo Clinic Stage III–IV and IVST >15 mm were independently associated with inferior overall survival (OS) in a multivariable analysis. IVST >15 mm was also adversely prognostic for OS in a subgroup of advanced-stage (revised Mayo Clinic stage III–IV) patients in a multivariable analysis (P < 0.001). Furthermore, advanced-stage patients with IVST >15 mm did not show survival benefit from treatment with bortezomib-based regimens and/or autologous stem-cell transplantation (ASCT). Our study demonstrated that IVST >15 mm is adversely prognostic independent of the revised Mayo Clinic staging system in patients with AL amyloidosis. In addition, the degree of IVST might be used as a useful prognostic indicator that can guide the management of patients with AL amyloidosis especially at an advanced stage.

Original languageEnglish
Pages (from-to)36-43
Number of pages8
JournalLeukemia Research
Volume60
DOIs
Publication statusPublished - 2017 Sep 1

Fingerprint

Amyloidosis
Survival
Immunoglobulin Light Chains
Stem Cell Transplantation

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Cho, Hyunsoo ; Kim, Soo Jeong ; Shim, ChiYoung ; Hong, Geu Ru ; Ha, Jong Won ; Kim, Yu Ri ; Yang, Woo Ick ; Chung, Haerim ; Jang, Ji Eun ; Cheong, June Won ; Min, Yoo Hong ; Kim, Jinseok. / Prognostic significance of interventricular septal thickness in patients with AL amyloidosis. In: Leukemia Research. 2017 ; Vol. 60. pp. 36-43.
@article{69e712f1cf3a467a8c7a06ae67cd65b0,
title = "Prognostic significance of interventricular septal thickness in patients with AL amyloidosis",
abstract = "The major prognostic determinant of immunoglobulin light chain (AL) amyloidosis is cardiac involvement. However, the role of interventricular septal thickness (IVST), which reflects the extent of cardiac involvement, remains unclear. Therefore, we analyzed 77 patients with newly diagnosed AL amyloidosis and evaluated the prognostic role of IVST. Fifty patients (64.9{\%}) had cardiac involvement and 17 patients (22.1{\%}) showed IVST >15 mm. Among all patients, the revised Mayo Clinic Stage III–IV and IVST >15 mm were independently associated with inferior overall survival (OS) in a multivariable analysis. IVST >15 mm was also adversely prognostic for OS in a subgroup of advanced-stage (revised Mayo Clinic stage III–IV) patients in a multivariable analysis (P < 0.001). Furthermore, advanced-stage patients with IVST >15 mm did not show survival benefit from treatment with bortezomib-based regimens and/or autologous stem-cell transplantation (ASCT). Our study demonstrated that IVST >15 mm is adversely prognostic independent of the revised Mayo Clinic staging system in patients with AL amyloidosis. In addition, the degree of IVST might be used as a useful prognostic indicator that can guide the management of patients with AL amyloidosis especially at an advanced stage.",
author = "Hyunsoo Cho and Kim, {Soo Jeong} and ChiYoung Shim and Hong, {Geu Ru} and Ha, {Jong Won} and Kim, {Yu Ri} and Yang, {Woo Ick} and Haerim Chung and Jang, {Ji Eun} and Cheong, {June Won} and Min, {Yoo Hong} and Jinseok Kim",
year = "2017",
month = "9",
day = "1",
doi = "10.1016/j.leukres.2017.06.008",
language = "English",
volume = "60",
pages = "36--43",
journal = "Leukemia Research",
issn = "0145-2126",
publisher = "Elsevier Limited",

}

Cho, H, Kim, SJ, Shim, C, Hong, GR, Ha, JW, Kim, YR, Yang, WI, Chung, H, Jang, JE, Cheong, JW, Min, YH & Kim, J 2017, 'Prognostic significance of interventricular septal thickness in patients with AL amyloidosis', Leukemia Research, vol. 60, pp. 36-43. https://doi.org/10.1016/j.leukres.2017.06.008

Prognostic significance of interventricular septal thickness in patients with AL amyloidosis. / Cho, Hyunsoo; Kim, Soo Jeong; Shim, ChiYoung; Hong, Geu Ru; Ha, Jong Won; Kim, Yu Ri; Yang, Woo Ick; Chung, Haerim; Jang, Ji Eun; Cheong, June Won; Min, Yoo Hong; Kim, Jinseok.

In: Leukemia Research, Vol. 60, 01.09.2017, p. 36-43.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostic significance of interventricular septal thickness in patients with AL amyloidosis

AU - Cho, Hyunsoo

AU - Kim, Soo Jeong

AU - Shim, ChiYoung

AU - Hong, Geu Ru

AU - Ha, Jong Won

AU - Kim, Yu Ri

AU - Yang, Woo Ick

AU - Chung, Haerim

AU - Jang, Ji Eun

AU - Cheong, June Won

AU - Min, Yoo Hong

AU - Kim, Jinseok

PY - 2017/9/1

Y1 - 2017/9/1

N2 - The major prognostic determinant of immunoglobulin light chain (AL) amyloidosis is cardiac involvement. However, the role of interventricular septal thickness (IVST), which reflects the extent of cardiac involvement, remains unclear. Therefore, we analyzed 77 patients with newly diagnosed AL amyloidosis and evaluated the prognostic role of IVST. Fifty patients (64.9%) had cardiac involvement and 17 patients (22.1%) showed IVST >15 mm. Among all patients, the revised Mayo Clinic Stage III–IV and IVST >15 mm were independently associated with inferior overall survival (OS) in a multivariable analysis. IVST >15 mm was also adversely prognostic for OS in a subgroup of advanced-stage (revised Mayo Clinic stage III–IV) patients in a multivariable analysis (P < 0.001). Furthermore, advanced-stage patients with IVST >15 mm did not show survival benefit from treatment with bortezomib-based regimens and/or autologous stem-cell transplantation (ASCT). Our study demonstrated that IVST >15 mm is adversely prognostic independent of the revised Mayo Clinic staging system in patients with AL amyloidosis. In addition, the degree of IVST might be used as a useful prognostic indicator that can guide the management of patients with AL amyloidosis especially at an advanced stage.

AB - The major prognostic determinant of immunoglobulin light chain (AL) amyloidosis is cardiac involvement. However, the role of interventricular septal thickness (IVST), which reflects the extent of cardiac involvement, remains unclear. Therefore, we analyzed 77 patients with newly diagnosed AL amyloidosis and evaluated the prognostic role of IVST. Fifty patients (64.9%) had cardiac involvement and 17 patients (22.1%) showed IVST >15 mm. Among all patients, the revised Mayo Clinic Stage III–IV and IVST >15 mm were independently associated with inferior overall survival (OS) in a multivariable analysis. IVST >15 mm was also adversely prognostic for OS in a subgroup of advanced-stage (revised Mayo Clinic stage III–IV) patients in a multivariable analysis (P < 0.001). Furthermore, advanced-stage patients with IVST >15 mm did not show survival benefit from treatment with bortezomib-based regimens and/or autologous stem-cell transplantation (ASCT). Our study demonstrated that IVST >15 mm is adversely prognostic independent of the revised Mayo Clinic staging system in patients with AL amyloidosis. In addition, the degree of IVST might be used as a useful prognostic indicator that can guide the management of patients with AL amyloidosis especially at an advanced stage.

UR - http://www.scopus.com/inward/record.url?scp=85021173959&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021173959&partnerID=8YFLogxK

U2 - 10.1016/j.leukres.2017.06.008

DO - 10.1016/j.leukres.2017.06.008

M3 - Article

C2 - 28648672

AN - SCOPUS:85021173959

VL - 60

SP - 36

EP - 43

JO - Leukemia Research

JF - Leukemia Research

SN - 0145-2126

ER -