Prognostic Significance of Lymph Node Status in p16+ Oropharyngeal Cancer After Surgical Treatment

Young Min Park, Tae Seong Eo, Yoon Woo Koh, Se Heon Kim, Eun Chang Choi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Objectives/Hypothesis: In this study, we retrospectively reviewed medical records of patients who underwent surgery for p16+ oropharyngeal cancer and analyzed the prognostic implications of pathologic lymph node (LN) status, including number of metastatic LNs, LN ratio, and location of metastatic LNs. Study Design: Retrospective case series. Methods: We retrospectively reviewed data on patients diagnosed with p16+ oropharyngeal cancer. Results: The study population consisted of 159 males and 29 females with a mean age of 57.2 years. The primary tumor sites were tonsils (n = 160), base of the tongue (n = 24), and soft palate (n = 4). Only recurrence-free survival (RFS) showed a significant correlation with contralateral LN metastasis on multivariate analysis. On Kaplan-Meier analysis, 5-year RFS was 92.4% in patients without contralateral LN metastasis and 68.8% in patients with contralateral LN metastasis. Conclusions: Among pathologic LN status in p16+ oropharyngeal cancer, only contralateral LN metastasis showed prognostic significance in disease recurrence of p16+ oropharyngeal squamous cell carcinoma patients. Level of Evidence: 4 Laryngoscope, 130: 1973–1979, 2020.

Original languageEnglish
Pages (from-to)1973-1979
Number of pages7
Issue number8
Publication statusPublished - 2020 Aug 1

Bibliographical note

Publisher Copyright:
© 2020 The American Laryngological, Rhinological and Otological Society, Inc.

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology


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