Prognostic Significance of Macroscopic Appearance in Clear Cell Renal Cell Carcinoma and Its Metastasis-Predicting Model

Se Un Jeong, Ja Min Park, Su Jin Shin, Jung Bok Lee, Cheryn Song, Heounjeong Go, Nam Hoon Cho, Jae Y. Ro, Yong Mee Cho

Research output: Contribution to journalArticle

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Abstract

Prognostic significance of macroscopic appearance of clear cell renal cell carcinoma (ccRCC) has not yet been studied. This study aimed to define the prognostic significance of macroscopic appearance and to propose a prognostic model for post-operative metastasis in ccRCC. A total of 1,025 patients with ccRCC were analyzed for the development dataset. A separate cohort of 399 such patients was used as an external validation dataset. Macroscopic appearances were initially divided into four groups, but were later divided into two groups: a simple nodular group (700 cases, 68.3%) and an irregular outline group (325 cases, 32.7%). During the 66.1-month mean follow-up period, 98 patients (9.6%) developed metastasis. Univariate analysis revealed that metastasis was associated with older age, radical nephrectomy, larger tumor size, higher tumor grade and stage, and the irregular outline group. On multivariate analysis, age, tumor size, and macroscopic appearance remained as independent prognostic factors. These factors were used to build a prognostic model, which divided into three risk groups. The probabilities of 5-year metastasis-free survival in the low-, intermediate-, and high-risk groups were 98%, 83%, and 53%, respectively. The results showed prognostic significance of macroscopic appearance in ccRCC and propose a prognostic model to guide post-operative management of patients with ccRCC.

Original languageEnglish
Pages (from-to)610-619
Number of pages10
JournalPathology International
Volume67
Issue number12
DOIs
Publication statusPublished - 2017 Dec

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Renal Cell Carcinoma
Neoplasm Metastasis
Neoplasms
Nephrectomy
Multivariate Analysis
Survival
Datasets

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Jeong, Se Un ; Park, Ja Min ; Shin, Su Jin ; Lee, Jung Bok ; Song, Cheryn ; Go, Heounjeong ; Cho, Nam Hoon ; Ro, Jae Y. ; Cho, Yong Mee. / Prognostic Significance of Macroscopic Appearance in Clear Cell Renal Cell Carcinoma and Its Metastasis-Predicting Model. In: Pathology International. 2017 ; Vol. 67, No. 12. pp. 610-619.
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Prognostic Significance of Macroscopic Appearance in Clear Cell Renal Cell Carcinoma and Its Metastasis-Predicting Model. / Jeong, Se Un; Park, Ja Min; Shin, Su Jin; Lee, Jung Bok; Song, Cheryn; Go, Heounjeong; Cho, Nam Hoon; Ro, Jae Y.; Cho, Yong Mee.

In: Pathology International, Vol. 67, No. 12, 12.2017, p. 610-619.

Research output: Contribution to journalArticle

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