Prognostic significance of paired epithelial cell adhesion molecule and E-cadherin in ovarian serous carcinoma

Hyo Sup Shim, Bo Sung Yoon, Nam Hoon Cho

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

This study was designed to investigate the prognostic significance of the expression of paired epithelial cell adhesion molecule and E-cadherin in ovarian serous carcinoma. The expression of epithelial cell adhesion molecule and E-cadherin was examined immunohistochemically on a tissue microarray of formalin-fixed paraffin-embedded tissue specimens from 72 consecutive patients. The overexpression of epithelial cell adhesion molecule was correlated with poor survival (P = .036). In contrast, the reduced expression of E-cadherin was correlated with poor survival (P = .034). When patients were subclassified into 4 groups according to positivity and negativity of epithelial cell adhesion molecule and E-cadherin expression, the epithelial cell adhesion molecule-positive E-cadherin-negative group showed the worst survival rate (P = .002, compared with the epithelial cell adhesion molecule-negative E-cadherin-positive group). These data suggest that the overexpression of epithelial cell adhesion molecule and reduced expression of E-cadherin in combination is more significant than a single marker for predicting poor survival.

Original languageEnglish
Pages (from-to)693-698
Number of pages6
JournalHuman Pathology
Volume40
Issue number5
DOIs
Publication statusPublished - 2009 May 1

Fingerprint

Cadherins
Carcinoma
Survival
Epithelial Cell Adhesion Molecule
Paraffin
Formaldehyde
Survival Rate

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

@article{a7e5ca62712a46ebbe5618dcde943c75,
title = "Prognostic significance of paired epithelial cell adhesion molecule and E-cadherin in ovarian serous carcinoma",
abstract = "This study was designed to investigate the prognostic significance of the expression of paired epithelial cell adhesion molecule and E-cadherin in ovarian serous carcinoma. The expression of epithelial cell adhesion molecule and E-cadherin was examined immunohistochemically on a tissue microarray of formalin-fixed paraffin-embedded tissue specimens from 72 consecutive patients. The overexpression of epithelial cell adhesion molecule was correlated with poor survival (P = .036). In contrast, the reduced expression of E-cadherin was correlated with poor survival (P = .034). When patients were subclassified into 4 groups according to positivity and negativity of epithelial cell adhesion molecule and E-cadherin expression, the epithelial cell adhesion molecule-positive E-cadherin-negative group showed the worst survival rate (P = .002, compared with the epithelial cell adhesion molecule-negative E-cadherin-positive group). These data suggest that the overexpression of epithelial cell adhesion molecule and reduced expression of E-cadherin in combination is more significant than a single marker for predicting poor survival.",
author = "Shim, {Hyo Sup} and Yoon, {Bo Sung} and Cho, {Nam Hoon}",
year = "2009",
month = "5",
day = "1",
doi = "10.1016/j.humpath.2008.10.013",
language = "English",
volume = "40",
pages = "693--698",
journal = "Human Pathology",
issn = "0046-8177",
publisher = "W.B. Saunders Ltd",
number = "5",

}

Prognostic significance of paired epithelial cell adhesion molecule and E-cadherin in ovarian serous carcinoma. / Shim, Hyo Sup; Yoon, Bo Sung; Cho, Nam Hoon.

In: Human Pathology, Vol. 40, No. 5, 01.05.2009, p. 693-698.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostic significance of paired epithelial cell adhesion molecule and E-cadherin in ovarian serous carcinoma

AU - Shim, Hyo Sup

AU - Yoon, Bo Sung

AU - Cho, Nam Hoon

PY - 2009/5/1

Y1 - 2009/5/1

N2 - This study was designed to investigate the prognostic significance of the expression of paired epithelial cell adhesion molecule and E-cadherin in ovarian serous carcinoma. The expression of epithelial cell adhesion molecule and E-cadherin was examined immunohistochemically on a tissue microarray of formalin-fixed paraffin-embedded tissue specimens from 72 consecutive patients. The overexpression of epithelial cell adhesion molecule was correlated with poor survival (P = .036). In contrast, the reduced expression of E-cadherin was correlated with poor survival (P = .034). When patients were subclassified into 4 groups according to positivity and negativity of epithelial cell adhesion molecule and E-cadherin expression, the epithelial cell adhesion molecule-positive E-cadherin-negative group showed the worst survival rate (P = .002, compared with the epithelial cell adhesion molecule-negative E-cadherin-positive group). These data suggest that the overexpression of epithelial cell adhesion molecule and reduced expression of E-cadherin in combination is more significant than a single marker for predicting poor survival.

AB - This study was designed to investigate the prognostic significance of the expression of paired epithelial cell adhesion molecule and E-cadherin in ovarian serous carcinoma. The expression of epithelial cell adhesion molecule and E-cadherin was examined immunohistochemically on a tissue microarray of formalin-fixed paraffin-embedded tissue specimens from 72 consecutive patients. The overexpression of epithelial cell adhesion molecule was correlated with poor survival (P = .036). In contrast, the reduced expression of E-cadherin was correlated with poor survival (P = .034). When patients were subclassified into 4 groups according to positivity and negativity of epithelial cell adhesion molecule and E-cadherin expression, the epithelial cell adhesion molecule-positive E-cadherin-negative group showed the worst survival rate (P = .002, compared with the epithelial cell adhesion molecule-negative E-cadherin-positive group). These data suggest that the overexpression of epithelial cell adhesion molecule and reduced expression of E-cadherin in combination is more significant than a single marker for predicting poor survival.

UR - http://www.scopus.com/inward/record.url?scp=64049083106&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=64049083106&partnerID=8YFLogxK

U2 - 10.1016/j.humpath.2008.10.013

DO - 10.1016/j.humpath.2008.10.013

M3 - Article

VL - 40

SP - 693

EP - 698

JO - Human Pathology

JF - Human Pathology

SN - 0046-8177

IS - 5

ER -