Prognostic significance of standardized uptake value on preoperative 18 F-FDG PET/CT in patients with ampullary adenocarcinoma

Hye Jin Choi, ChangMoo Kang, Kwanhyeong Jo, Woo Jung Lee, Jae Hoon Lee, Young Hoon Ryu, Jong Doo Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to investigate the prognostic value of 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with ampullary adenocarcinoma (AAC) after curative surgical resection. Methods: Fifty-two patients with AAC who had undergone 18 F-FDG PET/CT and subsequent curative resections were retrospectively enrolled. The maximum standardized uptake value (SUV max ) and tumor to background ratio (TBR) were measured on 18 F-FDG PET/CT in all patients. The prognostic significances of PET/CT parameters and clinicopathologic factors for recurrence-free survival (RFS) and overall survival (OS) were evaluated by univariate and multivariate analyses. Results: Of the 52 patients, 19 (36.5 %) experienced tumor recurrence during the follow-up period and 18 (35.8 %) died. The 3-year RFS and OS were 62.3 and 61.5 %, respectively. Preoperative CA19-9 level, tumor differentiation, presence of lymph node metastasis, SUV max , and TBR were significant prognostic factors for both RFS and OS (p < 0.05) on univariate analyses, and patient age showed significance only for predicting RFS (p < 0.05). On multivariate analyses, SUV max and TBR were independent prognostic factors for RFS, and tumor differentiation, SUV max , and TBR were independent prognostic factors for OS. Conclusion: SUV max and TBR on preoperative 18 F-FDG PET/CT are independent prognostic factors for predicting RFS and OS in patients with AAC; patients with high SUV max (>4.80) or TBR (>1.75) had poor survival outcomes. The role of and indications for adjuvant therapy after curative resection of AAC are still unclear. 18 F-FDG uptake in the primary tumor could provide additive prognostic information for the decision-making process regarding adjuvant therapy.

Original languageEnglish
Pages (from-to)841-847
Number of pages7
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume42
Issue number6
DOIs
Publication statusPublished - 2015 Apr 2

Fingerprint

Fluorodeoxyglucose F18
Adenocarcinoma
Survival
Recurrence
Neoplasms
Positron Emission Tomography Computed Tomography
Multivariate Analysis
Decision Making
Lymph Nodes
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Choi, Hye Jin ; Kang, ChangMoo ; Jo, Kwanhyeong ; Lee, Woo Jung ; Lee, Jae Hoon ; Ryu, Young Hoon ; Lee, Jong Doo. / Prognostic significance of standardized uptake value on preoperative 18 F-FDG PET/CT in patients with ampullary adenocarcinoma In: European Journal of Nuclear Medicine and Molecular Imaging. 2015 ; Vol. 42, No. 6. pp. 841-847.
@article{5118f7f8e9de4c65979bd08fce795195,
title = "Prognostic significance of standardized uptake value on preoperative 18 F-FDG PET/CT in patients with ampullary adenocarcinoma",
abstract = "Purpose: The purpose of this study was to investigate the prognostic value of 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with ampullary adenocarcinoma (AAC) after curative surgical resection. Methods: Fifty-two patients with AAC who had undergone 18 F-FDG PET/CT and subsequent curative resections were retrospectively enrolled. The maximum standardized uptake value (SUV max ) and tumor to background ratio (TBR) were measured on 18 F-FDG PET/CT in all patients. The prognostic significances of PET/CT parameters and clinicopathologic factors for recurrence-free survival (RFS) and overall survival (OS) were evaluated by univariate and multivariate analyses. Results: Of the 52 patients, 19 (36.5 {\%}) experienced tumor recurrence during the follow-up period and 18 (35.8 {\%}) died. The 3-year RFS and OS were 62.3 and 61.5 {\%}, respectively. Preoperative CA19-9 level, tumor differentiation, presence of lymph node metastasis, SUV max , and TBR were significant prognostic factors for both RFS and OS (p < 0.05) on univariate analyses, and patient age showed significance only for predicting RFS (p < 0.05). On multivariate analyses, SUV max and TBR were independent prognostic factors for RFS, and tumor differentiation, SUV max , and TBR were independent prognostic factors for OS. Conclusion: SUV max and TBR on preoperative 18 F-FDG PET/CT are independent prognostic factors for predicting RFS and OS in patients with AAC; patients with high SUV max (>4.80) or TBR (>1.75) had poor survival outcomes. The role of and indications for adjuvant therapy after curative resection of AAC are still unclear. 18 F-FDG uptake in the primary tumor could provide additive prognostic information for the decision-making process regarding adjuvant therapy.",
author = "Choi, {Hye Jin} and ChangMoo Kang and Kwanhyeong Jo and Lee, {Woo Jung} and Lee, {Jae Hoon} and Ryu, {Young Hoon} and Lee, {Jong Doo}",
year = "2015",
month = "4",
day = "2",
doi = "10.1007/s00259-014-2907-3",
language = "English",
volume = "42",
pages = "841--847",
journal = "European Journal of Nuclear Medicine and Molecular Imaging",
issn = "1619-7070",
publisher = "Springer Verlag",
number = "6",

}

Prognostic significance of standardized uptake value on preoperative 18 F-FDG PET/CT in patients with ampullary adenocarcinoma . / Choi, Hye Jin; Kang, ChangMoo; Jo, Kwanhyeong; Lee, Woo Jung; Lee, Jae Hoon; Ryu, Young Hoon; Lee, Jong Doo.

In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 42, No. 6, 02.04.2015, p. 841-847.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostic significance of standardized uptake value on preoperative 18 F-FDG PET/CT in patients with ampullary adenocarcinoma

AU - Choi, Hye Jin

AU - Kang, ChangMoo

AU - Jo, Kwanhyeong

AU - Lee, Woo Jung

AU - Lee, Jae Hoon

AU - Ryu, Young Hoon

AU - Lee, Jong Doo

PY - 2015/4/2

Y1 - 2015/4/2

N2 - Purpose: The purpose of this study was to investigate the prognostic value of 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with ampullary adenocarcinoma (AAC) after curative surgical resection. Methods: Fifty-two patients with AAC who had undergone 18 F-FDG PET/CT and subsequent curative resections were retrospectively enrolled. The maximum standardized uptake value (SUV max ) and tumor to background ratio (TBR) were measured on 18 F-FDG PET/CT in all patients. The prognostic significances of PET/CT parameters and clinicopathologic factors for recurrence-free survival (RFS) and overall survival (OS) were evaluated by univariate and multivariate analyses. Results: Of the 52 patients, 19 (36.5 %) experienced tumor recurrence during the follow-up period and 18 (35.8 %) died. The 3-year RFS and OS were 62.3 and 61.5 %, respectively. Preoperative CA19-9 level, tumor differentiation, presence of lymph node metastasis, SUV max , and TBR were significant prognostic factors for both RFS and OS (p < 0.05) on univariate analyses, and patient age showed significance only for predicting RFS (p < 0.05). On multivariate analyses, SUV max and TBR were independent prognostic factors for RFS, and tumor differentiation, SUV max , and TBR were independent prognostic factors for OS. Conclusion: SUV max and TBR on preoperative 18 F-FDG PET/CT are independent prognostic factors for predicting RFS and OS in patients with AAC; patients with high SUV max (>4.80) or TBR (>1.75) had poor survival outcomes. The role of and indications for adjuvant therapy after curative resection of AAC are still unclear. 18 F-FDG uptake in the primary tumor could provide additive prognostic information for the decision-making process regarding adjuvant therapy.

AB - Purpose: The purpose of this study was to investigate the prognostic value of 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with ampullary adenocarcinoma (AAC) after curative surgical resection. Methods: Fifty-two patients with AAC who had undergone 18 F-FDG PET/CT and subsequent curative resections were retrospectively enrolled. The maximum standardized uptake value (SUV max ) and tumor to background ratio (TBR) were measured on 18 F-FDG PET/CT in all patients. The prognostic significances of PET/CT parameters and clinicopathologic factors for recurrence-free survival (RFS) and overall survival (OS) were evaluated by univariate and multivariate analyses. Results: Of the 52 patients, 19 (36.5 %) experienced tumor recurrence during the follow-up period and 18 (35.8 %) died. The 3-year RFS and OS were 62.3 and 61.5 %, respectively. Preoperative CA19-9 level, tumor differentiation, presence of lymph node metastasis, SUV max , and TBR were significant prognostic factors for both RFS and OS (p < 0.05) on univariate analyses, and patient age showed significance only for predicting RFS (p < 0.05). On multivariate analyses, SUV max and TBR were independent prognostic factors for RFS, and tumor differentiation, SUV max , and TBR were independent prognostic factors for OS. Conclusion: SUV max and TBR on preoperative 18 F-FDG PET/CT are independent prognostic factors for predicting RFS and OS in patients with AAC; patients with high SUV max (>4.80) or TBR (>1.75) had poor survival outcomes. The role of and indications for adjuvant therapy after curative resection of AAC are still unclear. 18 F-FDG uptake in the primary tumor could provide additive prognostic information for the decision-making process regarding adjuvant therapy.

UR - http://www.scopus.com/inward/record.url?scp=84943699100&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943699100&partnerID=8YFLogxK

U2 - 10.1007/s00259-014-2907-3

DO - 10.1007/s00259-014-2907-3

M3 - Article

VL - 42

SP - 841

EP - 847

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

SN - 1619-7070

IS - 6

ER -