Prognostic significance of supradiaphragmatic lymph node metastasis detected by 18 F-FDG PET/CT in advanced epithelial ovarian cancer 11 Medical and Health Sciences 1103 Clinical Sciences 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis

In Ok Lee, Jung Yun Lee, Hyun Jeong Kim, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim, Chang Young Lee, Won Jun Kang, YoungTae Kim

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Abstract

Background: Supradiaphragmatic lymph node metastases (SdLNM) are frequently identified using 18 F-FDG positron emission tomography/computed tomography (PET/CT) in advanced epithelial ovarian cancers (AEOC). This study aimed to determine the prognostic significance of SdLNM detected by PET/CT in patients with AEOC. Methods: Medical records of patients diagnosed with AEOC were retrospectively registered from January 2009 to July 2015. Patients were categorized according to PET/CT stage: PET/CT stage III, PET/CT stage IV with SdLNM, and PET/CT stage IV with other metastases. Clinicopathologic characteristics, recurrence patterns, survival outcomes were compared according to PET/CT stage. Anatomical distribution of SdLNM and effect of thoracic debulking surgery were estimated. Results: A total of 295 patients were identified, including 176 patients who underwent primary debulking surgeries (PDS). Progression-free (P = 0.671) and overall (P = 0.525) survival did not differ significantly between patients with PET/CT IV with SdLNM and PET/CT IV with other metastases; however, patients with PET/CT IV with SdLNM had significantly poorer progression-free (P < 0.001) and overall (P = 0.016) survival than those with PET/CT stage III. Recurrence patterns were similar in all groups; intraperitoneal metastasis was the most common (78.8%) and thoracic recurrence alone accounted for less than 10%. Debulking of SdLNM lesions did not improve progression-free survival (P = 0.425) or overall survival (P = 0.465) of patients with AEOC. Conclusions: SdLNM detected using preoperative PET/CT are a negative prognostic factor in AEOC. Resection of suspicious SdLNM may not have effect to survival of patients with AEOC.

Original languageEnglish
Article number1165
JournalBMC cancer
Volume18
Issue number1
DOIs
Publication statusPublished - 2018 Nov 26

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Carcinogenesis
Lymph Nodes
Neoplasm Metastasis
Health
Survival
Recurrence
Positron Emission Tomography Computed Tomography
Ovarian epithelial cancer
Thoracic Surgery
Disease-Free Survival
Medical Records
Thorax

All Science Journal Classification (ASJC) codes

  • Oncology
  • Genetics
  • Cancer Research

Cite this

@article{142088454dfd40d2a4e9aa5644fc7603,
title = "Prognostic significance of supradiaphragmatic lymph node metastasis detected by 18 F-FDG PET/CT in advanced epithelial ovarian cancer 11 Medical and Health Sciences 1103 Clinical Sciences 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis",
abstract = "Background: Supradiaphragmatic lymph node metastases (SdLNM) are frequently identified using 18 F-FDG positron emission tomography/computed tomography (PET/CT) in advanced epithelial ovarian cancers (AEOC). This study aimed to determine the prognostic significance of SdLNM detected by PET/CT in patients with AEOC. Methods: Medical records of patients diagnosed with AEOC were retrospectively registered from January 2009 to July 2015. Patients were categorized according to PET/CT stage: PET/CT stage III, PET/CT stage IV with SdLNM, and PET/CT stage IV with other metastases. Clinicopathologic characteristics, recurrence patterns, survival outcomes were compared according to PET/CT stage. Anatomical distribution of SdLNM and effect of thoracic debulking surgery were estimated. Results: A total of 295 patients were identified, including 176 patients who underwent primary debulking surgeries (PDS). Progression-free (P = 0.671) and overall (P = 0.525) survival did not differ significantly between patients with PET/CT IV with SdLNM and PET/CT IV with other metastases; however, patients with PET/CT IV with SdLNM had significantly poorer progression-free (P < 0.001) and overall (P = 0.016) survival than those with PET/CT stage III. Recurrence patterns were similar in all groups; intraperitoneal metastasis was the most common (78.8{\%}) and thoracic recurrence alone accounted for less than 10{\%}. Debulking of SdLNM lesions did not improve progression-free survival (P = 0.425) or overall survival (P = 0.465) of patients with AEOC. Conclusions: SdLNM detected using preoperative PET/CT are a negative prognostic factor in AEOC. Resection of suspicious SdLNM may not have effect to survival of patients with AEOC.",
author = "Lee, {In Ok} and Lee, {Jung Yun} and Kim, {Hyun Jeong} and Nam, {Eun Ji} and Sunghoon Kim and Kim, {Sang Wun} and Lee, {Chang Young} and Kang, {Won Jun} and YoungTae Kim",
year = "2018",
month = "11",
day = "26",
doi = "10.1186/s12885-018-5067-1",
language = "English",
volume = "18",
journal = "BMC Cancer",
issn = "1471-2407",
publisher = "BioMed Central",
number = "1",

}

Prognostic significance of supradiaphragmatic lymph node metastasis detected by 18 F-FDG PET/CT in advanced epithelial ovarian cancer 11 Medical and Health Sciences 1103 Clinical Sciences 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis . / Lee, In Ok; Lee, Jung Yun; Kim, Hyun Jeong; Nam, Eun Ji; Kim, Sunghoon; Kim, Sang Wun; Lee, Chang Young; Kang, Won Jun; Kim, YoungTae.

In: BMC cancer, Vol. 18, No. 1, 1165, 26.11.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostic significance of supradiaphragmatic lymph node metastasis detected by 18 F-FDG PET/CT in advanced epithelial ovarian cancer 11 Medical and Health Sciences 1103 Clinical Sciences 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis

AU - Lee, In Ok

AU - Lee, Jung Yun

AU - Kim, Hyun Jeong

AU - Nam, Eun Ji

AU - Kim, Sunghoon

AU - Kim, Sang Wun

AU - Lee, Chang Young

AU - Kang, Won Jun

AU - Kim, YoungTae

PY - 2018/11/26

Y1 - 2018/11/26

N2 - Background: Supradiaphragmatic lymph node metastases (SdLNM) are frequently identified using 18 F-FDG positron emission tomography/computed tomography (PET/CT) in advanced epithelial ovarian cancers (AEOC). This study aimed to determine the prognostic significance of SdLNM detected by PET/CT in patients with AEOC. Methods: Medical records of patients diagnosed with AEOC were retrospectively registered from January 2009 to July 2015. Patients were categorized according to PET/CT stage: PET/CT stage III, PET/CT stage IV with SdLNM, and PET/CT stage IV with other metastases. Clinicopathologic characteristics, recurrence patterns, survival outcomes were compared according to PET/CT stage. Anatomical distribution of SdLNM and effect of thoracic debulking surgery were estimated. Results: A total of 295 patients were identified, including 176 patients who underwent primary debulking surgeries (PDS). Progression-free (P = 0.671) and overall (P = 0.525) survival did not differ significantly between patients with PET/CT IV with SdLNM and PET/CT IV with other metastases; however, patients with PET/CT IV with SdLNM had significantly poorer progression-free (P < 0.001) and overall (P = 0.016) survival than those with PET/CT stage III. Recurrence patterns were similar in all groups; intraperitoneal metastasis was the most common (78.8%) and thoracic recurrence alone accounted for less than 10%. Debulking of SdLNM lesions did not improve progression-free survival (P = 0.425) or overall survival (P = 0.465) of patients with AEOC. Conclusions: SdLNM detected using preoperative PET/CT are a negative prognostic factor in AEOC. Resection of suspicious SdLNM may not have effect to survival of patients with AEOC.

AB - Background: Supradiaphragmatic lymph node metastases (SdLNM) are frequently identified using 18 F-FDG positron emission tomography/computed tomography (PET/CT) in advanced epithelial ovarian cancers (AEOC). This study aimed to determine the prognostic significance of SdLNM detected by PET/CT in patients with AEOC. Methods: Medical records of patients diagnosed with AEOC were retrospectively registered from January 2009 to July 2015. Patients were categorized according to PET/CT stage: PET/CT stage III, PET/CT stage IV with SdLNM, and PET/CT stage IV with other metastases. Clinicopathologic characteristics, recurrence patterns, survival outcomes were compared according to PET/CT stage. Anatomical distribution of SdLNM and effect of thoracic debulking surgery were estimated. Results: A total of 295 patients were identified, including 176 patients who underwent primary debulking surgeries (PDS). Progression-free (P = 0.671) and overall (P = 0.525) survival did not differ significantly between patients with PET/CT IV with SdLNM and PET/CT IV with other metastases; however, patients with PET/CT IV with SdLNM had significantly poorer progression-free (P < 0.001) and overall (P = 0.016) survival than those with PET/CT stage III. Recurrence patterns were similar in all groups; intraperitoneal metastasis was the most common (78.8%) and thoracic recurrence alone accounted for less than 10%. Debulking of SdLNM lesions did not improve progression-free survival (P = 0.425) or overall survival (P = 0.465) of patients with AEOC. Conclusions: SdLNM detected using preoperative PET/CT are a negative prognostic factor in AEOC. Resection of suspicious SdLNM may not have effect to survival of patients with AEOC.

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U2 - 10.1186/s12885-018-5067-1

DO - 10.1186/s12885-018-5067-1

M3 - Article

VL - 18

JO - BMC Cancer

JF - BMC Cancer

SN - 1471-2407

IS - 1

M1 - 1165

ER -