Abstract
Background: Transient receptor potential vanilloid type 1 (TRPV1) has been studied in human malignancies, but has not been studied in epithelial ovarian cancer (EOC). We, therefore, investigated the significance of TRPV1 and correlation with phosphatase and tension homolog (PTEN) in EOC. Materials and Methods: Immunohistochemical analyses for TRPV1 and PTEN were performed using a tissue microarray. Moreover, the role of TRPV1 in cell growth was assessed in a EOC cell line. Results: High TRPV1 expression and the combination of high TRPV1 and low PTEN expression were an independent prognostic factor for overall survival and disease-free survival. In vitro results demonstrated that knockdown of TRPV1 was associated with decreased cell viability and colony formation. Conclusion: There is a strong association between TRPV1 and PTEN and the combination of TRPV1 and PTEN is a strong indicator of prognostic predictor in EOC.
| Original language | English |
|---|---|
| Pages (from-to) | 309-319 |
| Number of pages | 11 |
| Journal | Cancer Genomics and Proteomics |
| Volume | 17 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2020 |
Bibliographical note
Funding Information:This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) (NRF-2017M3A9B8 069610). This study was also supported by a faculty research grant of Yonsei University College of Medicine (6-2017-0160).
Publisher Copyright:
© 2020 International Institute of Anticancer Research. All rights reserved.
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
- Genetics
- Cancer Research
