Prognostic Validity of the American Joint Committee on Cancer and the European Neuroendocrine Tumors Staging Classifications for Pancreatic Neuroendocrine Tumors: A Retrospective Nationwide Multicenter Study in South Korea

Jae Hee Cho, Ji Kon Ryu, Si Young Song, Jin Hyeok Hwang, Dong Ki Lee, Sang Myung Woo, Young Eun Joo, Seok Jeong, Seung Ok Lee, Byung Kyu Park, Young Koog Cheon, Jimin Han, Tae Nyeun Kim, Jun Kyu Lee, Sung Hoon Moon, Hyunjin Kim, Eun Taek Park, Jae Chul Hwang, Tae Hyeon Kim, Tae Joo JeonChang Min Cho, Ho Soon Choi, Woo Jin Lee

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20 Citations (Scopus)

Abstract

Objectives Pancreatic neuroendocrine tumors (pNETs) are diverse diseases with different prognosis. The American Joint Committee on Cancer (AJCC) and the European Neuroendocrine Tumor Society (ENETS) introduced 2 different tumor node metastasis (TNM) stages, and the World Health Organization (WHO) proposed WHO 2010 grading system for pNETs. Therefore, we aimed to validate the prognostic relevance of these 3 systems for pNETs in South Korea. Methods The Korean Society of Gastrointestinal Cancer created a retrospective registry of pNETs in 153 patients from 15 hospitals between 2002 and 2012. Results On the basis of the WHO 2010 grade, 2-year progression-free-survival (PFS) rates for G1, G2, and G3 were 92%, 62%, and 25% (P < 0.01). According to ENETS and AJCC staging, 2-year PFS rates for stages I through IV were 94%, 87%, 49%, 20%, and 92%, 61%, 60%, 20%, respectively (P < 0.01). A Cox multivariate regression analysis revealed that the only statistically significant prognostic factor was the TNM classification of either the AJCC or the ENETS stage (P < 0.01). In addition, the κ value between the AJCC and the ENETS stages was 0.46 indicating a "moderate" agreement (P < 0.01). Conclusions The AJCC and ENETS TNM classifications for pNETs are prognostic for PFS and can be adopted in clinical practice in South Korea.

Original languageEnglish
Pages (from-to)941-946
Number of pages6
JournalPancreas
Volume45
Issue number7
DOIs
Publication statusPublished - 2016 Aug 1

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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    Cho, J. H., Ryu, J. K., Song, S. Y., Hwang, J. H., Lee, D. K., Woo, S. M., Joo, Y. E., Jeong, S., Lee, S. O., Park, B. K., Cheon, Y. K., Han, J., Kim, T. N., Lee, J. K., Moon, S. H., Kim, H., Park, E. T., Hwang, J. C., Kim, T. H., ... Lee, W. J. (2016). Prognostic Validity of the American Joint Committee on Cancer and the European Neuroendocrine Tumors Staging Classifications for Pancreatic Neuroendocrine Tumors: A Retrospective Nationwide Multicenter Study in South Korea. Pancreas, 45(7), 941-946. https://doi.org/10.1097/MPA.0000000000000586