Prognostic Validity of the American Joint Committee on Cancer and the European Neuroendocrine Tumors Staging Classifications for Pancreatic Neuroendocrine Tumors: A Retrospective Nationwide Multicenter Study in South Korea

Jae Hee Cho, Ji Kon Ryu, Si Young Song, Jin Hyeok Hwang, Dong Ki Lee, Sang Myung Woo, Young Eun Joo, Seok Jeong, Seung Ok Lee, Byung Kyu Park, Young Koog Cheon, Jimin Han, Tae Nyeun Kim, Jun Kyu Lee, Sung Hoon Moon, Hyunjin Kim, Eun Taek Park, Jae Chul Hwang, Tae Hyeon Kim, Tae Joo JeonChang Min Cho, Ho Soon Choi, Woo Jin Lee

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objectives Pancreatic neuroendocrine tumors (pNETs) are diverse diseases with different prognosis. The American Joint Committee on Cancer (AJCC) and the European Neuroendocrine Tumor Society (ENETS) introduced 2 different tumor node metastasis (TNM) stages, and the World Health Organization (WHO) proposed WHO 2010 grading system for pNETs. Therefore, we aimed to validate the prognostic relevance of these 3 systems for pNETs in South Korea. Methods The Korean Society of Gastrointestinal Cancer created a retrospective registry of pNETs in 153 patients from 15 hospitals between 2002 and 2012. Results On the basis of the WHO 2010 grade, 2-year progression-free-survival (PFS) rates for G1, G2, and G3 were 92%, 62%, and 25% (P < 0.01). According to ENETS and AJCC staging, 2-year PFS rates for stages I through IV were 94%, 87%, 49%, 20%, and 92%, 61%, 60%, 20%, respectively (P < 0.01). A Cox multivariate regression analysis revealed that the only statistically significant prognostic factor was the TNM classification of either the AJCC or the ENETS stage (P < 0.01). In addition, the κ value between the AJCC and the ENETS stages was 0.46 indicating a "moderate" agreement (P < 0.01). Conclusions The AJCC and ENETS TNM classifications for pNETs are prognostic for PFS and can be adopted in clinical practice in South Korea.

Original languageEnglish
Pages (from-to)941-946
Number of pages6
JournalPancreas
Volume45
Issue number7
DOIs
Publication statusPublished - 2016 Aug 1

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Republic of Korea
Neuroendocrine Tumors
Neoplasm Staging
Multicenter Studies
Neoplasms
Disease-Free Survival
Neoplasm Metastasis
Survival Rate
Gastrointestinal Neoplasms
Registries
Multivariate Analysis
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Cho, Jae Hee ; Ryu, Ji Kon ; Song, Si Young ; Hwang, Jin Hyeok ; Lee, Dong Ki ; Woo, Sang Myung ; Joo, Young Eun ; Jeong, Seok ; Lee, Seung Ok ; Park, Byung Kyu ; Cheon, Young Koog ; Han, Jimin ; Kim, Tae Nyeun ; Lee, Jun Kyu ; Moon, Sung Hoon ; Kim, Hyunjin ; Park, Eun Taek ; Hwang, Jae Chul ; Kim, Tae Hyeon ; Jeon, Tae Joo ; Cho, Chang Min ; Choi, Ho Soon ; Lee, Woo Jin. / Prognostic Validity of the American Joint Committee on Cancer and the European Neuroendocrine Tumors Staging Classifications for Pancreatic Neuroendocrine Tumors : A Retrospective Nationwide Multicenter Study in South Korea. In: Pancreas. 2016 ; Vol. 45, No. 7. pp. 941-946.
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title = "Prognostic Validity of the American Joint Committee on Cancer and the European Neuroendocrine Tumors Staging Classifications for Pancreatic Neuroendocrine Tumors: A Retrospective Nationwide Multicenter Study in South Korea",
abstract = "Objectives Pancreatic neuroendocrine tumors (pNETs) are diverse diseases with different prognosis. The American Joint Committee on Cancer (AJCC) and the European Neuroendocrine Tumor Society (ENETS) introduced 2 different tumor node metastasis (TNM) stages, and the World Health Organization (WHO) proposed WHO 2010 grading system for pNETs. Therefore, we aimed to validate the prognostic relevance of these 3 systems for pNETs in South Korea. Methods The Korean Society of Gastrointestinal Cancer created a retrospective registry of pNETs in 153 patients from 15 hospitals between 2002 and 2012. Results On the basis of the WHO 2010 grade, 2-year progression-free-survival (PFS) rates for G1, G2, and G3 were 92{\%}, 62{\%}, and 25{\%} (P < 0.01). According to ENETS and AJCC staging, 2-year PFS rates for stages I through IV were 94{\%}, 87{\%}, 49{\%}, 20{\%}, and 92{\%}, 61{\%}, 60{\%}, 20{\%}, respectively (P < 0.01). A Cox multivariate regression analysis revealed that the only statistically significant prognostic factor was the TNM classification of either the AJCC or the ENETS stage (P < 0.01). In addition, the κ value between the AJCC and the ENETS stages was 0.46 indicating a {"}moderate{"} agreement (P < 0.01). Conclusions The AJCC and ENETS TNM classifications for pNETs are prognostic for PFS and can be adopted in clinical practice in South Korea.",
author = "Cho, {Jae Hee} and Ryu, {Ji Kon} and Song, {Si Young} and Hwang, {Jin Hyeok} and Lee, {Dong Ki} and Woo, {Sang Myung} and Joo, {Young Eun} and Seok Jeong and Lee, {Seung Ok} and Park, {Byung Kyu} and Cheon, {Young Koog} and Jimin Han and Kim, {Tae Nyeun} and Lee, {Jun Kyu} and Moon, {Sung Hoon} and Hyunjin Kim and Park, {Eun Taek} and Hwang, {Jae Chul} and Kim, {Tae Hyeon} and Jeon, {Tae Joo} and Cho, {Chang Min} and Choi, {Ho Soon} and Lee, {Woo Jin}",
year = "2016",
month = "8",
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doi = "10.1097/MPA.0000000000000586",
language = "English",
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pages = "941--946",
journal = "Pancreas",
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Cho, JH, Ryu, JK, Song, SY, Hwang, JH, Lee, DK, Woo, SM, Joo, YE, Jeong, S, Lee, SO, Park, BK, Cheon, YK, Han, J, Kim, TN, Lee, JK, Moon, SH, Kim, H, Park, ET, Hwang, JC, Kim, TH, Jeon, TJ, Cho, CM, Choi, HS & Lee, WJ 2016, 'Prognostic Validity of the American Joint Committee on Cancer and the European Neuroendocrine Tumors Staging Classifications for Pancreatic Neuroendocrine Tumors: A Retrospective Nationwide Multicenter Study in South Korea', Pancreas, vol. 45, no. 7, pp. 941-946. https://doi.org/10.1097/MPA.0000000000000586

Prognostic Validity of the American Joint Committee on Cancer and the European Neuroendocrine Tumors Staging Classifications for Pancreatic Neuroendocrine Tumors : A Retrospective Nationwide Multicenter Study in South Korea. / Cho, Jae Hee; Ryu, Ji Kon; Song, Si Young; Hwang, Jin Hyeok; Lee, Dong Ki; Woo, Sang Myung; Joo, Young Eun; Jeong, Seok; Lee, Seung Ok; Park, Byung Kyu; Cheon, Young Koog; Han, Jimin; Kim, Tae Nyeun; Lee, Jun Kyu; Moon, Sung Hoon; Kim, Hyunjin; Park, Eun Taek; Hwang, Jae Chul; Kim, Tae Hyeon; Jeon, Tae Joo; Cho, Chang Min; Choi, Ho Soon; Lee, Woo Jin.

In: Pancreas, Vol. 45, No. 7, 01.08.2016, p. 941-946.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostic Validity of the American Joint Committee on Cancer and the European Neuroendocrine Tumors Staging Classifications for Pancreatic Neuroendocrine Tumors

T2 - A Retrospective Nationwide Multicenter Study in South Korea

AU - Cho, Jae Hee

AU - Ryu, Ji Kon

AU - Song, Si Young

AU - Hwang, Jin Hyeok

AU - Lee, Dong Ki

AU - Woo, Sang Myung

AU - Joo, Young Eun

AU - Jeong, Seok

AU - Lee, Seung Ok

AU - Park, Byung Kyu

AU - Cheon, Young Koog

AU - Han, Jimin

AU - Kim, Tae Nyeun

AU - Lee, Jun Kyu

AU - Moon, Sung Hoon

AU - Kim, Hyunjin

AU - Park, Eun Taek

AU - Hwang, Jae Chul

AU - Kim, Tae Hyeon

AU - Jeon, Tae Joo

AU - Cho, Chang Min

AU - Choi, Ho Soon

AU - Lee, Woo Jin

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Objectives Pancreatic neuroendocrine tumors (pNETs) are diverse diseases with different prognosis. The American Joint Committee on Cancer (AJCC) and the European Neuroendocrine Tumor Society (ENETS) introduced 2 different tumor node metastasis (TNM) stages, and the World Health Organization (WHO) proposed WHO 2010 grading system for pNETs. Therefore, we aimed to validate the prognostic relevance of these 3 systems for pNETs in South Korea. Methods The Korean Society of Gastrointestinal Cancer created a retrospective registry of pNETs in 153 patients from 15 hospitals between 2002 and 2012. Results On the basis of the WHO 2010 grade, 2-year progression-free-survival (PFS) rates for G1, G2, and G3 were 92%, 62%, and 25% (P < 0.01). According to ENETS and AJCC staging, 2-year PFS rates for stages I through IV were 94%, 87%, 49%, 20%, and 92%, 61%, 60%, 20%, respectively (P < 0.01). A Cox multivariate regression analysis revealed that the only statistically significant prognostic factor was the TNM classification of either the AJCC or the ENETS stage (P < 0.01). In addition, the κ value between the AJCC and the ENETS stages was 0.46 indicating a "moderate" agreement (P < 0.01). Conclusions The AJCC and ENETS TNM classifications for pNETs are prognostic for PFS and can be adopted in clinical practice in South Korea.

AB - Objectives Pancreatic neuroendocrine tumors (pNETs) are diverse diseases with different prognosis. The American Joint Committee on Cancer (AJCC) and the European Neuroendocrine Tumor Society (ENETS) introduced 2 different tumor node metastasis (TNM) stages, and the World Health Organization (WHO) proposed WHO 2010 grading system for pNETs. Therefore, we aimed to validate the prognostic relevance of these 3 systems for pNETs in South Korea. Methods The Korean Society of Gastrointestinal Cancer created a retrospective registry of pNETs in 153 patients from 15 hospitals between 2002 and 2012. Results On the basis of the WHO 2010 grade, 2-year progression-free-survival (PFS) rates for G1, G2, and G3 were 92%, 62%, and 25% (P < 0.01). According to ENETS and AJCC staging, 2-year PFS rates for stages I through IV were 94%, 87%, 49%, 20%, and 92%, 61%, 60%, 20%, respectively (P < 0.01). A Cox multivariate regression analysis revealed that the only statistically significant prognostic factor was the TNM classification of either the AJCC or the ENETS stage (P < 0.01). In addition, the κ value between the AJCC and the ENETS stages was 0.46 indicating a "moderate" agreement (P < 0.01). Conclusions The AJCC and ENETS TNM classifications for pNETs are prognostic for PFS and can be adopted in clinical practice in South Korea.

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U2 - 10.1097/MPA.0000000000000586

DO - 10.1097/MPA.0000000000000586

M3 - Article

C2 - 26765964

AN - SCOPUS:84979513587

VL - 45

SP - 941

EP - 946

JO - Pancreas

JF - Pancreas

SN - 0885-3177

IS - 7

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