Prognostic value of change in red cell distribution width 1 month after discharge in acute decompensated heart failure patients

Jaewon Oh, Seok Min Kang, Hoyoun Won, Namki Hong, Soo Young Kim, Sungha Park, Sang Hak Lee, Yangsoo Jang, Namsik Chung

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Red cell distribution width (RDW) is a novel prognostic marker independently associated with adverse outcomes in acute decompensated heart failure (ADHF) patients. The aim of the present study was to assess whether the change in RDW after discharge had prognostic value in patients with ADHF. Methods and Results: RDW was measured in 261 patients admitted with ADHF, at admission and at discharge and 1 month after discharge. Cardiovascular (CV) events were defined as CV mortality and heart failure rehospitalization. Kaplan-Meier analysis showed that patients with positive RDW change between admission and 1 month after discharge (RDWΔ 1Mdis-adm; n=136) had a significantly higher number of CV events compared with patients with no positive RDWΔ 1Mdis-adm (n=125; 60.3% vs. 47.2%, log-rank: P=0.007). On Cox hazards analysis, a positive RDWΔ 1Mdis-adm was an independent predictor of CV events after adjusting for other CV risk factors (hazard ratio, 1.740; 95% confidence interval: 1.149-2.633, P=0.009). Conclusions: A novel relationship was noted between positive RDWΔ 1Mdis-adm and CV events in ADHF patients. Measurement of RDW at 1 month after ADHF assists in the prediction of adverse CV outcomes. Therefore, repeated measurement of RDW is a simple and inexpensive method that may facilitate assessment of CV risk stratification in patients with ADHF.

Original languageEnglish
Pages (from-to)109-116
Number of pages8
JournalCirculation Journal
Volume76
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

Fingerprint

Erythrocyte Indices
Heart Failure
Kaplan-Meier Estimate
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Oh, Jaewon ; Kang, Seok Min ; Won, Hoyoun ; Hong, Namki ; Kim, Soo Young ; Park, Sungha ; Lee, Sang Hak ; Jang, Yangsoo ; Chung, Namsik. / Prognostic value of change in red cell distribution width 1 month after discharge in acute decompensated heart failure patients. In: Circulation Journal. 2012 ; Vol. 76, No. 1. pp. 109-116.
@article{5bc5a50e9caf4788b8f36fa33715b8ef,
title = "Prognostic value of change in red cell distribution width 1 month after discharge in acute decompensated heart failure patients",
abstract = "Background: Red cell distribution width (RDW) is a novel prognostic marker independently associated with adverse outcomes in acute decompensated heart failure (ADHF) patients. The aim of the present study was to assess whether the change in RDW after discharge had prognostic value in patients with ADHF. Methods and Results: RDW was measured in 261 patients admitted with ADHF, at admission and at discharge and 1 month after discharge. Cardiovascular (CV) events were defined as CV mortality and heart failure rehospitalization. Kaplan-Meier analysis showed that patients with positive RDW change between admission and 1 month after discharge (RDWΔ 1Mdis-adm; n=136) had a significantly higher number of CV events compared with patients with no positive RDWΔ 1Mdis-adm (n=125; 60.3{\%} vs. 47.2{\%}, log-rank: P=0.007). On Cox hazards analysis, a positive RDWΔ 1Mdis-adm was an independent predictor of CV events after adjusting for other CV risk factors (hazard ratio, 1.740; 95{\%} confidence interval: 1.149-2.633, P=0.009). Conclusions: A novel relationship was noted between positive RDWΔ 1Mdis-adm and CV events in ADHF patients. Measurement of RDW at 1 month after ADHF assists in the prediction of adverse CV outcomes. Therefore, repeated measurement of RDW is a simple and inexpensive method that may facilitate assessment of CV risk stratification in patients with ADHF.",
author = "Jaewon Oh and Kang, {Seok Min} and Hoyoun Won and Namki Hong and Kim, {Soo Young} and Sungha Park and Lee, {Sang Hak} and Yangsoo Jang and Namsik Chung",
year = "2012",
month = "1",
day = "1",
doi = "10.1253/circj.CJ-11-0664",
language = "English",
volume = "76",
pages = "109--116",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "1",

}

Prognostic value of change in red cell distribution width 1 month after discharge in acute decompensated heart failure patients. / Oh, Jaewon; Kang, Seok Min; Won, Hoyoun; Hong, Namki; Kim, Soo Young; Park, Sungha; Lee, Sang Hak; Jang, Yangsoo; Chung, Namsik.

In: Circulation Journal, Vol. 76, No. 1, 01.01.2012, p. 109-116.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostic value of change in red cell distribution width 1 month after discharge in acute decompensated heart failure patients

AU - Oh, Jaewon

AU - Kang, Seok Min

AU - Won, Hoyoun

AU - Hong, Namki

AU - Kim, Soo Young

AU - Park, Sungha

AU - Lee, Sang Hak

AU - Jang, Yangsoo

AU - Chung, Namsik

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Background: Red cell distribution width (RDW) is a novel prognostic marker independently associated with adverse outcomes in acute decompensated heart failure (ADHF) patients. The aim of the present study was to assess whether the change in RDW after discharge had prognostic value in patients with ADHF. Methods and Results: RDW was measured in 261 patients admitted with ADHF, at admission and at discharge and 1 month after discharge. Cardiovascular (CV) events were defined as CV mortality and heart failure rehospitalization. Kaplan-Meier analysis showed that patients with positive RDW change between admission and 1 month after discharge (RDWΔ 1Mdis-adm; n=136) had a significantly higher number of CV events compared with patients with no positive RDWΔ 1Mdis-adm (n=125; 60.3% vs. 47.2%, log-rank: P=0.007). On Cox hazards analysis, a positive RDWΔ 1Mdis-adm was an independent predictor of CV events after adjusting for other CV risk factors (hazard ratio, 1.740; 95% confidence interval: 1.149-2.633, P=0.009). Conclusions: A novel relationship was noted between positive RDWΔ 1Mdis-adm and CV events in ADHF patients. Measurement of RDW at 1 month after ADHF assists in the prediction of adverse CV outcomes. Therefore, repeated measurement of RDW is a simple and inexpensive method that may facilitate assessment of CV risk stratification in patients with ADHF.

AB - Background: Red cell distribution width (RDW) is a novel prognostic marker independently associated with adverse outcomes in acute decompensated heart failure (ADHF) patients. The aim of the present study was to assess whether the change in RDW after discharge had prognostic value in patients with ADHF. Methods and Results: RDW was measured in 261 patients admitted with ADHF, at admission and at discharge and 1 month after discharge. Cardiovascular (CV) events were defined as CV mortality and heart failure rehospitalization. Kaplan-Meier analysis showed that patients with positive RDW change between admission and 1 month after discharge (RDWΔ 1Mdis-adm; n=136) had a significantly higher number of CV events compared with patients with no positive RDWΔ 1Mdis-adm (n=125; 60.3% vs. 47.2%, log-rank: P=0.007). On Cox hazards analysis, a positive RDWΔ 1Mdis-adm was an independent predictor of CV events after adjusting for other CV risk factors (hazard ratio, 1.740; 95% confidence interval: 1.149-2.633, P=0.009). Conclusions: A novel relationship was noted between positive RDWΔ 1Mdis-adm and CV events in ADHF patients. Measurement of RDW at 1 month after ADHF assists in the prediction of adverse CV outcomes. Therefore, repeated measurement of RDW is a simple and inexpensive method that may facilitate assessment of CV risk stratification in patients with ADHF.

UR - http://www.scopus.com/inward/record.url?scp=84255183874&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84255183874&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-11-0664

DO - 10.1253/circj.CJ-11-0664

M3 - Article

C2 - 22033347

AN - SCOPUS:84255183874

VL - 76

SP - 109

EP - 116

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 1

ER -