TY - JOUR
T1 - Prognostic value of left atrial volume index in patients with rheumatic mitral stenosis
AU - Cho, In Jeong
AU - Jeong, Hyeonju
AU - Chang, Hyuk Jae
N1 - Publisher Copyright:
© 2021 The Authors. Clinical Cardiology published by Wiley Periodicals LLC.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021
Y1 - 2021
N2 - Background: The significance of left atrial volume index (LAVI) for predicting outcomes in patients with mitral stenosis (MS) has been unclear, even though rheumatic MS is known to be associated with left atrium enlargement and functional deterioration. Hypothesis: The current study aimed to investigate the prognostic value of LAVI, based on the severity in patients with rheumatic MS. Methods: We retrospectively reviewed 611 patients with pure rheumatic MS. The prognostic value of LAVI and the effect of MS severity on the prognostic value of LAVI for events were evaluated. The events were defined as a composite end-point that included all-cause death, heart failure admission, mitral valve replacement, percutaneous mitral valvuloplasty, and stroke. Results: There were 236 (38.6%) overall events during a median follow-up of 8 months. The optimal LAVI cutoff for the prognostic threshold was 57 ml/m2. The MS severity had a significant effect on the prognostic value of LAVI. A LAVI >57 ml/m2 was a prognostic value for events in progressive MS (hazard ratio [HR]: 2.40, 95% confidence interval [CI]: 1.41–5.40, p =.004) and in patients with severe MS (HR: 1.70, 95% CI: 1.06–2.74, p =.029), but it was not prognostic in patients with very severe MS (HR: 1.02, 95% CI: 0.56–1.84, p =.955). Conclusions: The prognostic value of LAVI varies and is dependent on the MS severity. A LAVI >57 mL/m2 was independently associated with poor outcomes in patients with progressive MS, while this association was minimized in patients with severe MS.
AB - Background: The significance of left atrial volume index (LAVI) for predicting outcomes in patients with mitral stenosis (MS) has been unclear, even though rheumatic MS is known to be associated with left atrium enlargement and functional deterioration. Hypothesis: The current study aimed to investigate the prognostic value of LAVI, based on the severity in patients with rheumatic MS. Methods: We retrospectively reviewed 611 patients with pure rheumatic MS. The prognostic value of LAVI and the effect of MS severity on the prognostic value of LAVI for events were evaluated. The events were defined as a composite end-point that included all-cause death, heart failure admission, mitral valve replacement, percutaneous mitral valvuloplasty, and stroke. Results: There were 236 (38.6%) overall events during a median follow-up of 8 months. The optimal LAVI cutoff for the prognostic threshold was 57 ml/m2. The MS severity had a significant effect on the prognostic value of LAVI. A LAVI >57 ml/m2 was a prognostic value for events in progressive MS (hazard ratio [HR]: 2.40, 95% confidence interval [CI]: 1.41–5.40, p =.004) and in patients with severe MS (HR: 1.70, 95% CI: 1.06–2.74, p =.029), but it was not prognostic in patients with very severe MS (HR: 1.02, 95% CI: 0.56–1.84, p =.955). Conclusions: The prognostic value of LAVI varies and is dependent on the MS severity. A LAVI >57 mL/m2 was independently associated with poor outcomes in patients with progressive MS, while this association was minimized in patients with severe MS.
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U2 - 10.1002/clc.23544
DO - 10.1002/clc.23544
M3 - Article
AN - SCOPUS:85099046799
JO - Clinical Cardiology
JF - Clinical Cardiology
SN - 0160-9289
ER -